STRINGSTRING
ENG ENG HES1 HES1 ENSUMAP00000002305 ENSUMAP00000002305 CCN1 CCN1 LOC103665211 LOC103665211 HAND1 HAND1 SMAD4 SMAD4 TBX20 TBX20 SAV1 SAV1 WHSC1 WHSC1 ENSUMAP00000008398 ENSUMAP00000008398 SMO SMO ENSUMAP00000010815 ENSUMAP00000010815 JAG1 JAG1 GJA5 GJA5 TBX5 TBX5 TBX3 TBX3 TGFBR1 TGFBR1 CHD7 CHD7 ENSUMAP00000018664 ENSUMAP00000018664 LRP2 LRP2 SEMA3C SEMA3C BMPR1A BMPR1A BMP4 BMP4 PARVA PARVA TP53 TP53 PROX1 PROX1 APLNR APLNR ZFPM2 ZFPM2 MDM2 MDM2 DHRS3 DHRS3 GATA4 GATA4 BMPR2 BMPR2 DNAH11 DNAH11 NRP2 NRP2 MKS1 MKS1 SLIT3 SLIT3 NOTCH2 NOTCH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENGEndoglin. (609 aa)
HES1Transcription factor HES-1. (166 aa)
ENSUMAP00000002305annotation not available (122 aa)
CCN1Cellular communication network factor 1. (382 aa)
LOC103665211Mothers against decapentaplegic homolog. (244 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1. (62 aa)
SMAD4Mothers against decapentaplegic homolog. (546 aa)
TBX20T-box transcription factor TBX20. (447 aa)
SAV1Salvador family WW domain containing protein 1. (351 aa)
WHSC1LOW QUALITY PROTEIN: histone-lysine N-methyltransferase NSD2. (629 aa)
ENSUMAP00000008398annotation not available (577 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (745 aa)
ENSUMAP00000010815annotation not available (220 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
TBX5T-box transcription factor TBX5. (474 aa)
TBX3LOW QUALITY PROTEIN: T-box transcription factor TBX3. (130 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
CHD7chromodomain-helicase-DNA-binding protein 7. (2976 aa)
ENSUMAP00000018664annotation not available (401 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (403 aa)
SEMA3CSemaphorin-3C; Belongs to the semaphorin family. (750 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
PARVAAlpha-parvin isoform X2. (356 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
PROX1Prospero homeobox protein 1. (737 aa)
APLNRApelin receptor. (330 aa)
ZFPM2Zinc finger protein ZFPM2. (1193 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
DHRS3Short-chain dehydrogenase/reductase 3 isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
GATA4Transcription factor GATA-4. (236 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
DNAH11LOW QUALITY PROTEIN: dynein heavy chain 11, axonemal. (4485 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
SLIT3Slit homolog 3 protein. (1412 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (2444 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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