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SEMA3A SEMA3A ENG ENG LEF1 LEF1 ACTG2 ACTG2 HES1 HES1 TGFBR3 TGFBR3 EFNB1 EFNB1 PHOX2B PHOX2B ALX1 ALX1 LOXL3 LOXL3 TEAD2 TEAD2 SEMA4F SEMA4F ENSUMAP00000002305 ENSUMAP00000002305 LRP6 LRP6 KITLG KITLG WNT2 WNT2 SEMA6C SEMA6C HAND1 HAND1 SMAD4 SMAD4 TBX20 TBX20 WNT16 WNT16 FAM83D FAM83D MAPK1 MAPK1 ANXA6 ANXA6 TRIM28 TRIM28 PAX1 PAX1 TCOF1 TCOF1 PKD2 PKD2 ENSUMAP00000005635 ENSUMAP00000005635 ACTA1 ACTA1 NUP133 NUP133 LOXL2 LOXL2 SEMA7A SEMA7A BMP2 BMP2 MEF2C MEF2C KLHL12 KLHL12 FAM172A FAM172A ACVR1 ACVR1 LOC103677394 LOC103677394 CORO1C CORO1C FGF10 FGF10 HNF1A HNF1A SNAI2 SNAI2 AKNA AKNA SMO SMO OTUD5 OTUD5 RADIL RADIL FOXF1 FOXF1 NODAL NODAL SEMA6B SEMA6B SEMA4B SEMA4B GDNF GDNF JAG1 JAG1 PTK7 PTK7 CUL7 CUL7 CUL7-2 CUL7-2 ACVRL1 ACVRL1 PEF1 PEF1 YAP1 YAP1 SEMA6D SEMA6D ZFP36L1 ZFP36L1 TBX5 TBX5 TBX3 TBX3 MAPK3 MAPK3 PHACTR4 PHACTR4 RANBP3L RANBP3L SEMA4C SEMA4C SMAD3 SMAD3 WWTR1 WWTR1 ACTA2 ACTA2 TGFBR1 TGFBR1 SIX2 SIX2 HIF1A HIF1A ENSUMAP00000018722 ENSUMAP00000018722 SIX1 SIX1 DLG5 DLG5 SEMA3C SEMA3C BMPR1A BMPR1A DDX17 DDX17 ENSUMAP00000020010 ENSUMAP00000020010 EXOC4 EXOC4 SOX10 SOX10 FGF9 FGF9 LOC103659865 LOC103659865 EDNRA EDNRA BMP4 BMP4 NRP1 NRP1 SEMA4D-2 SEMA4D-2 SFRP2 SFRP2 SEMA4D SEMA4D WNT8A WNT8A RET RET SEMA3E SEMA3E ERBB3 ERBB3 RTN4 RTN4 HTR2B HTR2B FRZB FRZB SEMA3D SEMA3D BNC2 BNC2 DDX5 DDX5 EDN1 EDN1 APLNR APLNR SEMA4A SEMA4A RDH10 RDH10 WNT10A WNT10A SEMA6A SEMA6A LOC103656603 LOC103656603 ROCK1 ROCK1 ADAM15 ADAM15 TASOR TASOR TMEM100 TMEM100 ENSUMAP00000028257 ENSUMAP00000028257 TGFB2 TGFB2 EXT1 EXT1 FLNA FLNA MDM2 MDM2 PPP3R1 PPP3R1 SOX8 SOX8 AMER1 AMER1 SEMA3G SEMA3G GATA4 GATA4 BMPR2 BMPR2 SEMA3B SEMA3B HAS2 HAS2 SEMA3F SEMA3F PDCD6 PDCD6 ENSUMAP00000030969 ENSUMAP00000030969 SEMA5A SEMA5A NRP2 NRP2 SEMA4G SEMA4G NOLC1 NOLC1 OSR1 OSR1 ALDH1A2 ALDH1A2 KBTBD8 KBTBD8 TCF21 TCF21 SNAI1 SNAI1 GSK3B GSK3B POGLUT1 POGLUT1 SFRP1 SFRP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SEMA3ASemaphorin-3A; Belongs to the semaphorin family. (772 aa)
ENGEndoglin. (609 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X2. (450 aa)
ACTG2Actin, gamma-enteric smooth muscle. (376 aa)
HES1Transcription factor HES-1. (166 aa)
TGFBR3Transforming growth factor beta receptor type 3. (808 aa)
EFNB1ephrin-B1; Belongs to the ephrin family. (418 aa)
PHOX2BPaired mesoderm homeobox protein 2B. (187 aa)
ALX1ALX homeobox protein 1. (326 aa)
LOXL3Lysyl oxidase homolog 3 isoform X1. (753 aa)
TEAD2Transcriptional enhancer factor TEF-4. (440 aa)
SEMA4Fsemaphorin-4F isoform X1; Belongs to the semaphorin family. (767 aa)
ENSUMAP00000002305annotation not available (122 aa)
LRP6Low-density lipoprotein receptor-related protein 6 isoform X1. (1462 aa)
KITLGKit ligand. (274 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
SEMA6Csemaphorin-6C; Belongs to the semaphorin family. (804 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1. (62 aa)
SMAD4Mothers against decapentaplegic homolog. (546 aa)
TBX20T-box transcription factor TBX20. (447 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
FAM83DProtein FAM83D. (421 aa)
MAPK1Mitogen-activated protein kinase. (363 aa)
ANXA6Annexin. (704 aa)
TRIM28Transcription intermediary factor 1-beta. (821 aa)
PAX1Paired box protein Pax-1. (357 aa)
TCOF1LOW QUALITY PROTEIN: treacle protein. (1403 aa)
PKD2Polycystin-2. (831 aa)
ENSUMAP00000005635annotation not available (292 aa)
ACTA1Actin, alpha skeletal muscle. (256 aa)
NUP133Nuclear pore complex protein Nup133. (1156 aa)
LOXL2Lysyl oxidase homolog 2 isoform X3. (829 aa)
SEMA7Asemaphorin-7A; Belongs to the semaphorin family. (662 aa)
BMP2Bone morphogenetic protein 2 isoform X2. (395 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X3. (433 aa)
KLHL12LOW QUALITY PROTEIN: kelch-like protein 12. (536 aa)
FAM172AFamily with sequence similarity 172 member A. (420 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
LOC103677394Transforming growth factor beta-1. (299 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (474 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
HNF1AHepatocyte nuclear factor 1-alpha. (660 aa)
SNAI2Zinc finger protein SNAI2. (263 aa)
AKNAAT-hook-containing transcription factor. (1401 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (745 aa)
OTUD5OTU domain-containing protein 5. (439 aa)
RADILRas-associating and dilute domain-containing protein. (442 aa)
FOXF1Forkhead box protein F1. (370 aa)
NODALNodal homolog. (271 aa)
SEMA6Bsemaphorin-6B; Belongs to the semaphorin family. (648 aa)
SEMA4BLOW QUALITY PROTEIN: semaphorin-4B; Belongs to the semaphorin family. (847 aa)
GDNFGlial cell line-derived neurotrophic factor. (241 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
PTK7Inactive tyrosine-protein kinase 7; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1081 aa)
CUL7LOW QUALITY PROTEIN: cullin-7; Belongs to the cullin family. (613 aa)
CUL7-2Cullin 7. (229 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
PEF1Penta-EF-hand domain containing 1. (316 aa)
YAP1LOW QUALITY PROTEIN: yorkie homolog. (457 aa)
SEMA6Dsemaphorin-6D isoform X1; Belongs to the semaphorin family. (1086 aa)
ZFP36L1Zinc finger protein 36, C3H1 type-like 1. (338 aa)
TBX5T-box transcription factor TBX5. (474 aa)
TBX3LOW QUALITY PROTEIN: T-box transcription factor TBX3. (130 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
PHACTR4Phosphatase and actin regulator. (706 aa)
RANBP3LRan-binding protein 3-like isoform X1. (491 aa)
SEMA4Csemaphorin-4C; Belongs to the semaphorin family. (843 aa)
SMAD3Mothers against decapentaplegic homolog. (280 aa)
WWTR1WW domain-containing transcription regulator protein 1. (397 aa)
ACTA2Actin alpha 2, smooth muscle. (377 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
SIX2LOW QUALITY PROTEIN: homeobox protein SIX2. (267 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X2. (823 aa)
ENSUMAP00000018722annotation not available (372 aa)
SIX1Homeobox protein SIX1. (284 aa)
DLG5Disks large homolog 5; Belongs to the MAGUK family. (1852 aa)
SEMA3CSemaphorin-3C; Belongs to the semaphorin family. (750 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
DDX17Probable ATP-dependent RNA helicase DDX17; Belongs to the DEAD box helicase family. (422 aa)
ENSUMAP00000020010annotation not available (183 aa)
EXOC4Exocyst complex component 4 isoform X1. (968 aa)
SOX10Transcription factor SOX-10. (305 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LOC103659865Actin-like. (128 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
SEMA4D-2Semaphorin 4D. (117 aa)
SFRP2Secreted frizzled-related protein 2. (299 aa)
SEMA4Dsemaphorin-4D; Belongs to the semaphorin family. (777 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (326 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1131 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (781 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1342 aa)
RTN4Reticulon. (978 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
SEMA3Dsemaphorin-3D; Belongs to the semaphorin family. (743 aa)
BNC2Zinc finger protein basonuclin-2 isoform X3. (1085 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (614 aa)
EDN1Endothelin-1. (202 aa)
APLNRApelin receptor. (330 aa)
SEMA4Asemaphorin-4A; Belongs to the semaphorin family. (778 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (321 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (270 aa)
SEMA6ALOW QUALITY PROTEIN: semaphorin-6A; Belongs to the semaphorin family. (1028 aa)
LOC103656603Testis-specific Y-encoded protein 1-like; Belongs to the nucleosome assembly protein (NAP) family. (242 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
ADAM15Disintegrin and metalloproteinase domain-containing protein 15. (772 aa)
TASORProtein FAM208A. (1555 aa)
TMEM100Transmembrane protein 100. (134 aa)
ENSUMAP00000028257annotation not available (265 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (501 aa)
FLNAfilamin-A. (2549 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
PPP3R1Calcineurin subunit B type 1. (160 aa)
SOX8Transcription factor SOX-8. (216 aa)
AMER1LOW QUALITY PROTEIN: APC membrane recruitment protein 1. (1098 aa)
SEMA3Gsemaphorin-3G; Belongs to the semaphorin family. (748 aa)
GATA4Transcription factor GATA-4. (236 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
SEMA3Bsemaphorin-3B; Belongs to the semaphorin family. (677 aa)
HAS2Hyaluronan synthase 2 isoform X1. (588 aa)
SEMA3Fsemaphorin-3F; Belongs to the semaphorin family. (578 aa)
PDCD6Programmed cell death protein 6. (185 aa)
ENSUMAP00000030969annotation not available (251 aa)
SEMA5ALOW QUALITY PROTEIN: semaphorin-5A. (1055 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
SEMA4GLOW QUALITY PROTEIN: semaphorin-4G; Belongs to the semaphorin family. (464 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1 isoform X1. (708 aa)
OSR1Protein odd-skipped-related 1. (272 aa)
ALDH1A2Retinal dehydrogenase 2 isoform X2; Belongs to the aldehyde dehydrogenase family. (521 aa)
KBTBD8Kelch repeat and BTB domain-containing protein 8. (601 aa)
TCF21Transcription factor 21. (179 aa)
SNAI1Zinc finger protein SNAI1. (246 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
POGLUT1Protein O-glucosyltransferase 1. (408 aa)
SFRP1Secreted frizzled-related protein 1. (305 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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