STRINGSTRING
WASF1 WASF1 SFRP1 SFRP1 LAMB2 LAMB2 DCX DCX MST1 MST1 NRP2 NRP2 SEMA5A SEMA5A MED12 MED12 RAPH1 RAPH1 LHX1 LHX1 SEMA3F SEMA3F SLIT1 SLIT1 IMPACT IMPACT ADPRHL1 ADPRHL1 EXT1 EXT1 SSNA1 SSNA1 LOC103660022 LOC103660022 DCLK1 DCLK1 USP9X USP9X LLPH LLPH TNR TNR DDR1 DDR1 NRN1L NRN1L RDH10 RDH10 NRN1 NRN1 IST1 IST1 EDN1 EDN1 CDKL3 CDKL3 JADE2 JADE2 NDEL1 NDEL1 MED1 MED1 SFRP2 SFRP2 ITGB1 ITGB1 TMEM108 TMEM108 BMP4 BMP4 EDNRA EDNRA RYK RYK ENSUMAP00000020965 ENSUMAP00000020965 EFNA5 EFNA5 APP APP SPRY2 SPRY2 PLXNA1 PLXNA1 LIMK1 LIMK1 SPAG6 SPAG6 CSF1 CSF1 PAK6 PAK6 VCL VCL FGF1 FGF1 PRKCZ PRKCZ RARG RARG LOC103680202 LOC103680202 IQGAP1 IQGAP1 YAP1 YAP1 COBL COBL PTK7 PTK7 FLRT3 FLRT3 SRF SRF SPG11 SPG11 ENSUMAP00000010849 ENSUMAP00000010849 MAP1B MAP1B HDAC6 HDAC6 AREG AREG FGF10 FGF10 C9orf72 C9orf72 STK11 STK11 ALCAM ALCAM NIN NIN KDM5B KDM5B SEMA7A SEMA7A BIN3 BIN3 SPRY1 SPRY1 CTNNB1 CTNNB1 CPNE1 CPNE1 TRIM28 TRIM28 SLIT2 SLIT2 LHX2 LHX2 ULK1 ULK1 LPAR3 LPAR3 CYFIP2 CYFIP2 ESR1 ESR1 LOC103682075 LOC103682075 SPART SPART SLIT3 SLIT3 ADPRH ADPRH CYFIP1 CYFIP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WASF1wiskott-Aldrich syndrome protein family member 1 isoform X2. (559 aa)
SFRP1Secreted frizzled-related protein 1. (305 aa)
LAMB2Laminin subunit beta-2. (1726 aa)
DCXLOW QUALITY PROTEIN: neuronal migration protein doublecortin. (349 aa)
MST1Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (680 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
SEMA5ALOW QUALITY PROTEIN: semaphorin-5A. (1055 aa)
MED12LOW QUALITY PROTEIN: mediator of RNA polymerase II transcription subunit 12. (2045 aa)
RAPH1Ras-associated and pleckstrin homology domains-containing protein 1-like isoform X2. (1113 aa)
LHX1LOW QUALITY PROTEIN: LIM/homeobox protein Lhx1. (395 aa)
SEMA3Fsemaphorin-3F; Belongs to the semaphorin family. (578 aa)
SLIT1LOW QUALITY PROTEIN: slit homolog 1 protein. (1320 aa)
IMPACTImpact RWD domain protein. (300 aa)
ADPRHL1[Protein ADP-ribosylarginine] hydrolase-like protein 1 isoform X2. (354 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (501 aa)
SSNA1Sjoegren syndrome nuclear autoantigen 1. (188 aa)
LOC103660022LOW QUALITY PROTEIN: necdin. (106 aa)
DCLK1LOW QUALITY PROTEIN: serine/threonine-protein kinase DCLK1. (722 aa)
USP9XLOW QUALITY PROTEIN: probable ubiquitin carboxyl-terminal hydrolase FAF-X; Belongs to the peptidase C19 family. (2463 aa)
LLPHLLP homolog, long-term synaptic facilitation factor. (127 aa)
TNRtenascin-R. (1349 aa)
DDR1Epithelial discoidin domain-containing receptor 1. (920 aa)
NRN1LNeuritin-like protein. (162 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (321 aa)
NRN1Neuritin 1. (142 aa)
IST1IST1 factor associated with ESCRT-III. (366 aa)
EDN1Endothelin-1. (202 aa)
CDKL3Cyclin-dependent kinase-like 3 isoform X2. (603 aa)
JADE2LOW QUALITY PROTEIN: protein Jade-2. (805 aa)
NDEL1Nuclear distribution protein nudE-like 1 isoform X2. (337 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (614 aa)
SFRP2Secreted frizzled-related protein 2. (299 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
TMEM108Transmembrane protein 108. (581 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
RYKTyrosine-protein kinase RYK. (572 aa)
ENSUMAP00000020965annotation not available (111 aa)
EFNA5ephrin-A5; Belongs to the ephrin family. (188 aa)
APPGamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (747 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
PLXNA1LOW QUALITY PROTEIN: plexin-A1. (1729 aa)
LIMK1LIM domain kinase 1. (653 aa)
SPAG6Sperm-associated antigen 6. (494 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (553 aa)
PAK6Non-specific serine/threonine protein kinase. (677 aa)
VCLVinculin isoform X1. (1059 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (557 aa)
RARGRetinoic acid receptor gamma isoform X1. (458 aa)
LOC103680202Probable ubiquitin carboxyl-terminal hydrolase FAF-X; Belongs to the peptidase C19 family. (2531 aa)
IQGAP1Ras GTPase-activating-like protein IQGAP1. (1677 aa)
YAP1LOW QUALITY PROTEIN: yorkie homolog. (457 aa)
COBLProtein cordon-bleu. (1346 aa)
PTK7Inactive tyrosine-protein kinase 7; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1081 aa)
FLRT3Fibronectin leucine rich transmembrane protein 3. (649 aa)
SRFSerum response factor. (446 aa)
SPG11Spatacsin isoform X2. (2445 aa)
ENSUMAP00000010849annotation not available (93 aa)
MAP1BLOW QUALITY PROTEIN: microtubule-associated protein 1B. (2372 aa)
HDAC6LOW QUALITY PROTEIN: histone deacetylase 6. (976 aa)
AREGAmphiregulin. (253 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (457 aa)
ALCAMActivated leukocyte cell adhesion molecule. (583 aa)
NINLOW QUALITY PROTEIN: ninein. (1951 aa)
KDM5BLysine-specific demethylase 5B. (1493 aa)
SEMA7Asemaphorin-7A; Belongs to the semaphorin family. (662 aa)
BIN3Bridging integrator 3. (216 aa)
SPRY1Protein sprouty homolog 1 isoform X1. (311 aa)
CTNNB1Catenin beta-1. (787 aa)
CPNE1Copine-1. (537 aa)
TRIM28Transcription intermediary factor 1-beta. (821 aa)
SLIT2Slit homolog 2 protein isoform X1. (1530 aa)
LHX2LIM/homeobox protein Lhx2. (331 aa)
ULK1Serine/threonine-protein kinase ULK1. (835 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (354 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1056 aa)
ESR1LOW QUALITY PROTEIN: estrogen receptor. (328 aa)
LOC103682075Segment polarity protein dishevelled homolog DVL-1-like. (893 aa)
SPARTSpartin isoform X2. (672 aa)
SLIT3Slit homolog 3 protein. (1412 aa)
ADPRHADP-ribosylarginine hydrolase. (362 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1185 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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