STRINGSTRING
CTSH CTSH TBX3 TBX3 PLEKHH1 PLEKHH1 RALA RALA RARG RARG GLI3 GLI3 PTCH1 PTCH1 YAP1 YAP1 COBL COBL TMEM59L TMEM59L ACVRL1 ACVRL1 ENSUMAP00000011628 ENSUMAP00000011628 PTK7 PTK7 DLL1 DLL1 SRF SRF PAX8 PAX8 GDNF GDNF ENSUMAP00000010865 ENSUMAP00000010865 NODAL NODAL ENSUMAP00000010549 ENSUMAP00000010549 BBS4 BBS4 SHROOM3 SHROOM3 FOXF1 FOXF1 HECTD1 HECTD1 TCTN1 TCTN1 FUZ FUZ SMO SMO AREG AREG WNT1 WNT1 ENSUMAP00000007957 ENSUMAP00000007957 DVL3 DVL3 KDR KDR ST14 ST14 FGF10 FGF10 KDM2B KDM2B MEF2C MEF2C KDM5B KDM5B IFT57 IFT57 PML PML BMP2 BMP2 CITED1 CITED1 SPRY1 SPRY1 FGF2 FGF2 PKHD1 PKHD1 ASB2 ASB2 CTNNB1 CTNNB1 PKD2 PKD2 LRRC1 LRRC1 SETD2 SETD2 GZF1 GZF1 SRC SRC SLIT2 SLIT2 OPA1 OPA1 PHB2 PHB2 KRAS KRAS TBX20 TBX20 SMAD4 SMAD4 HAND1 HAND1 DLG1 DLG1 LHX2 LHX2 MTHFD1L MTHFD1L PRKACB PRKACB BCL10 BCL10 GREB1 GREB1 ESR1 ESR1 FKBP14 FKBP14 LOC103682075 LOC103682075 CC2D2A CC2D2A TEAD2 TEAD2 ENSUMAP00000001989 ENSUMAP00000001989 HS2ST1 HS2ST1 LMO4 LMO4 ARL13B ARL13B CTSZ CTSZ IFT52 IFT52 VDR VDR CLUAP1 CLUAP1 HES1 HES1 LIAS LIAS RASIP1 RASIP1 SEC24B SEC24B SCRIB SCRIB LEF1 LEF1 ILK ILK ENG ENG ENSUMAP00000000290 ENSUMAP00000000290 GNA13 GNA13 CLIC4 CLIC4 RYR2 RYR2 ENSUMAP00000017266 ENSUMAP00000017266 BRD2 BRD2 SPINT1 SPINT1 DLL4 DLL4 SMAD3 SMAD3 GPC3 GPC3 SEMA4C SEMA4C FGF1 FGF1 NOTCH2 NOTCH2 SFRP1 SFRP1 STK4 STK4 WNK4 WNK4 TCF21 TCF21 TIE1 TIE1 SALL4 SALL4 PRICKLE1 PRICKLE1 CTNNBIP1 CTNNBIP1 AHI1 AHI1 DLG2 DLG2 ARHGAP35 ARHGAP35 STARD13 STARD13 VASP VASP SUFU SUFU OSR1 OSR1 KAT2A KAT2A CSMD1 CSMD1 BTRC BTRC NFATC4 NFATC4 MKS1 MKS1 MTHFR MTHFR DAG1 DAG1 NPNT NPNT MST1 MST1 FZD3 FZD3 MTSS1 MTSS1 MED12 MED12 LHX1 LHX1 SOSTDC1 SOSTDC1 ADAMTS16 ADAMTS16 SOX8 SOX8 PPP3R1 PPP3R1 LGR5 LGR5 KDM6A KDM6A EXT1 EXT1 DDR1 DDR1 CTHRC1 CTHRC1 MIB1 MIB1 LGR4 LGR4 GREB1L GREB1L HESX1 HESX1 WT1 WT1 FOXH1 FOXH1 PRKX PRKX IHH IHH ESRP2 ESRP2 RDH10 RDH10 LAMA1 LAMA1 ENSUMAP00000025747 ENSUMAP00000025747 EYA1 EYA1 ABL1 ABL1 PLXNB2 PLXNB2 SPINT2 SPINT2 APLNR APLNR EPHA4 EPHA4 EDN1 EDN1 PODXL PODXL PLXND1 PLXND1 TCAP TCAP TRAF6 TRAF6 MED1 MED1 TIMELESS TIMELESS STK3 STK3 SEMA3E SEMA3E TSC1 TSC1 RET RET KLHL3 KLHL3 MICALCL MICALCL SFRP2 SFRP2 MICAL2 MICAL2 NPHP3 NPHP3 GREM1 GREM1 BMP4 BMP4 EDNRA EDNRA DNAAF1 DNAAF1 GDF2 GDF2 WNT9B WNT9B HHIP HHIP DVL2 DVL2 TULP3 TULP3 SPRY2 SPRY2 SHH SHH CCDC103 CCDC103 CCDC40 CCDC40 CSNK2B CSNK2B LY6G5B LY6G5B MMP14 MMP14 LRP5 LRP5 DLG5 DLG5 LRP2 LRP2 ENSUMAP00000018664 ENSUMAP00000018664 HIF1A HIF1A CSF1 CSF1 MTHFD1 MTHFD1 LUZP1 LUZP1 GRHL3 GRHL3 CECR2 CECR2 PAK1 PAK1 GLMN GLMN PHACTR4 PHACTR4 TBX6 TBX6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTSHLOW QUALITY PROTEIN: pro-cathepsin H; Belongs to the peptidase C1 family. (295 aa)
TBX3LOW QUALITY PROTEIN: T-box transcription factor TBX3. (130 aa)
PLEKHH1Pleckstrin homology domain-containing family H member 1. (229 aa)
RALARAS like proto-oncogene A. (206 aa)
RARGRetinoic acid receptor gamma isoform X1. (458 aa)
GLI3Transcriptional activator GLI3. (524 aa)
PTCH1Protein patched homolog 1. (1388 aa)
YAP1LOW QUALITY PROTEIN: yorkie homolog. (457 aa)
COBLProtein cordon-bleu. (1346 aa)
TMEM59LLOW QUALITY PROTEIN: transmembrane protein 59-like. (352 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
ENSUMAP00000011628annotation not available (93 aa)
PTK7Inactive tyrosine-protein kinase 7; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1081 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (695 aa)
SRFSerum response factor. (446 aa)
PAX8Paired box protein Pax-8. (459 aa)
GDNFGlial cell line-derived neurotrophic factor. (241 aa)
ENSUMAP00000010865annotation not available (218 aa)
NODALNodal homolog. (271 aa)
ENSUMAP00000010549annotation not available (144 aa)
BBS4Bardet-Biedl syndrome 4 protein isoform X2. (325 aa)
SHROOM3Protein Shroom3. (1875 aa)
FOXF1Forkhead box protein F1. (370 aa)
HECTD1LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HECTD1. (2507 aa)
TCTN1Tectonic family member 1. (589 aa)
FUZLOW QUALITY PROTEIN: protein fuzzy homolog. (373 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (745 aa)
AREGAmphiregulin. (253 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (334 aa)
ENSUMAP00000007957annotation not available (154 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3. (423 aa)
KDRLOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1344 aa)
ST14Suppressor of tumorigenicity 14 protein. (807 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
KDM2BLOW QUALITY PROTEIN: lysine-specific demethylase 2B. (685 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X3. (433 aa)
KDM5BLysine-specific demethylase 5B. (1493 aa)
IFT57Intraflagellar transport protein 57 homolog. (390 aa)
PMLPromyelocytic leukemia. (880 aa)
BMP2Bone morphogenetic protein 2 isoform X2. (395 aa)
CITED1Cbp/p300-interacting transactivator 1. (201 aa)
SPRY1Protein sprouty homolog 1 isoform X1. (311 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
PKHD1LOW QUALITY PROTEIN: fibrocystin. (4039 aa)
ASB2LOW QUALITY PROTEIN: ankyrin repeat and SOCS box protein 2. (512 aa)
CTNNB1Catenin beta-1. (787 aa)
PKD2Polycystin-2. (831 aa)
LRRC1Leucine-rich repeat-containing protein 1. (493 aa)
SETD2Histone-lysine N-methyltransferase SETD2. (2520 aa)
GZF1GDNF-inducible zinc finger protein 1 isoform X1. (715 aa)
SRCTyrosine-protein kinase. (618 aa)
SLIT2Slit homolog 2 protein isoform X1. (1530 aa)
OPA1Dynamin-like 120 kDa protein, mitochondrial; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (997 aa)
PHB2Prohibitin. (297 aa)
KRASGTPase KRas isoform X3. (189 aa)
TBX20T-box transcription factor TBX20. (447 aa)
SMAD4Mothers against decapentaplegic homolog. (546 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1. (62 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
LHX2LIM/homeobox protein Lhx2. (331 aa)
MTHFD1LMonofunctional C1-tetrahydrofolate synthase, mitochondrial. (759 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
BCL10BCL10 immune signaling adaptor. (234 aa)
GREB1LOW QUALITY PROTEIN: protein GREB1. (1897 aa)
ESR1LOW QUALITY PROTEIN: estrogen receptor. (328 aa)
FKBP14Peptidylprolyl isomerase. (211 aa)
LOC103682075Segment polarity protein dishevelled homolog DVL-1-like. (893 aa)
CC2D2ACoiled-coil and C2 domain-containing protein 2A isoform X1. (1619 aa)
TEAD2Transcriptional enhancer factor TEF-4. (440 aa)
ENSUMAP00000001989annotation not available (146 aa)
HS2ST1Heparan sulfate 2-O-sulfotransferase 1. (333 aa)
LMO4LIM domain transcription factor LMO4. (165 aa)
ARL13BADP-ribosylation factor-like protein 13B isoform X1. (428 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (289 aa)
IFT52Intraflagellar transport protein 52 homolog isoform X1. (454 aa)
VDRVitamin D3 receptor isoform X2. (427 aa)
CLUAP1Clusterin-associated protein 1 isoform X3. (438 aa)
HES1Transcription factor HES-1. (166 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (373 aa)
RASIP1Ras-interacting protein 1. (318 aa)
SEC24BProtein transport protein Sec24B. (1144 aa)
SCRIBLOW QUALITY PROTEIN: protein scribble homolog. (844 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X2. (450 aa)
ILKIntegrin-linked protein kinase. (452 aa)
ENGEndoglin. (609 aa)
ENSUMAP00000000290annotation not available (71 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13. (300 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (252 aa)
RYR2Ryanodine receptor 2. (4923 aa)
ENSUMAP00000017266annotation not available (147 aa)
BRD2Bromodomain-containing protein 2 isoform X2. (414 aa)
SPINT1Kunitz-type protease inhibitor 1. (501 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (701 aa)
SMAD3Mothers against decapentaplegic homolog. (280 aa)
GPC3Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (625 aa)
SEMA4Csemaphorin-4C; Belongs to the semaphorin family. (843 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (2444 aa)
SFRP1Secreted frizzled-related protein 1. (305 aa)
STK4Serine/threonine-protein kinase 4. (496 aa)
WNK4Serine/threonine-protein kinase WNK4. (1215 aa)
TCF21Transcription factor 21. (179 aa)
TIE1Tyrosine-protein kinase receptor Tie-1. (907 aa)
SALL4Sal-like protein 4. (1021 aa)
PRICKLE1Prickle-like protein 1. (804 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
AHI1LOW QUALITY PROTEIN: jouberin. (1133 aa)
DLG2Disks large homolog 2 isoform X1. (843 aa)
ARHGAP35Rho GTPase-activating protein 35. (1500 aa)
STARD13StAR related lipid transfer domain containing 13. (1107 aa)
VASPVasodilator-stimulated phosphoprotein. (363 aa)
SUFUSuppressor of fused homolog. (489 aa)
OSR1Protein odd-skipped-related 1. (272 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (787 aa)
CSMD1CUB and sushi domain-containing protein 1. (3099 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
NFATC4LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4. (787 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (695 aa)
DAG1Dystroglycan 1. (888 aa)
NPNTNephronectin. (562 aa)
MST1Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (680 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
MTSS1Metastasis suppressor protein 1. (782 aa)
MED12LOW QUALITY PROTEIN: mediator of RNA polymerase II transcription subunit 12. (2045 aa)
LHX1LOW QUALITY PROTEIN: LIM/homeobox protein Lhx1. (395 aa)
SOSTDC1Sclerostin domain-containing protein 1. (206 aa)
ADAMTS16A disintegrin and metalloproteinase with thrombospondin motifs 16. (1201 aa)
SOX8Transcription factor SOX-8. (216 aa)
PPP3R1Calcineurin subunit B type 1. (160 aa)
LGR5Leucine-rich repeat-containing G-protein coupled receptor 5. (895 aa)
KDM6ALysine-specific demethylase 6A. (1347 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (501 aa)
DDR1Epithelial discoidin domain-containing receptor 1. (920 aa)
CTHRC1LOW QUALITY PROTEIN: collagen triple helix repeat-containing protein 1. (113 aa)
MIB1LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase MIB1. (974 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4. (905 aa)
GREB1LGREB1-like protein. (1776 aa)
HESX1Homeobox expressed in ES cells 1. (181 aa)
WT1Wilms tumor protein isoform X1. (305 aa)
FOXH1Forkhead box protein H1 isoform X1. (370 aa)
PRKXcAMP-dependent protein kinase catalytic subunit PRKX. (329 aa)
IHHIndian hedgehog protein. (145 aa)
ESRP2Epithelial splicing regulatory protein 2. (616 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (321 aa)
LAMA1Laminin subunit alpha-1. (3009 aa)
ENSUMAP00000025747annotation not available (76 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
ABL1Tyrosine-protein kinase. (1135 aa)
PLXNB2LOW QUALITY PROTEIN: plexin-B2. (1590 aa)
SPINT2Kunitz-type protease inhibitor 2 isoform X1. (232 aa)
APLNRApelin receptor. (330 aa)
EPHA4Ephrin type-A receptor 4 isoform X1. (911 aa)
EDN1Endothelin-1. (202 aa)
PODXLPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (505 aa)
PLXND1LOW QUALITY PROTEIN: plexin-D1. (1503 aa)
TCAPTelethonin. (167 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (614 aa)
TIMELESSTimeless circadian regulator. (1208 aa)
STK3Serine/threonine-protein kinase 3. (497 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (781 aa)
TSC1Hamartin. (1168 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1131 aa)
KLHL3Kelch-like protein 3. (607 aa)
MICALCLMICAL C-terminal-like protein. (584 aa)
SFRP2Secreted frizzled-related protein 2. (299 aa)
MICAL2Protein-methionine sulfoxide oxidase MICAL2 isoform X1. (1120 aa)
NPHP3Nephrocystin-3. (1266 aa)
GREM1Gremlin. (232 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
DNAAF1Dynein assembly factor 1, axonemal. (699 aa)
GDF2Growth/differentiation factor 2. (402 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
HHIPHedgehog-interacting protein isoform X1. (700 aa)
DVL2LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2. (391 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (462 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
SHHSonic hedgehog protein. (168 aa)
CCDC103Coiled-coil domain-containing protein 103. (242 aa)
CCDC40Coiled-coil domain-containing protein 40. (186 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (250 aa)
LY6G5BLymphocyte antigen 6 complex locus protein G5b. (217 aa)
MMP14Matrix metalloproteinase-14. (571 aa)
LRP5Low-density lipoprotein receptor-related protein 5. (1602 aa)
DLG5Disks large homolog 5; Belongs to the MAGUK family. (1852 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (403 aa)
ENSUMAP00000018664annotation not available (401 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X2. (823 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (553 aa)
MTHFD1C-1-tetrahydrofolate synthase, cytoplasmic. (935 aa)
LUZP1Leucine zipper protein 1 isoform X1. (1074 aa)
GRHL3Grainyhead-like protein 3 homolog isoform X1. (700 aa)
CECR2Cat eye syndrome critical region protein 2. (1454 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
GLMNGlomulin, FKBP associated protein. (600 aa)
PHACTR4Phosphatase and actin regulator. (706 aa)
TBX6LOW QUALITY PROTEIN: T-box transcription factor TBX6. (407 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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