(11 nodes) Heart formation network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SMARCD3	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3. (502 aa)
	FOXH1	Forkhead box protein H1 isoform X1. (370 aa)
	AXIN2	Axin-2. (764 aa)
	EXT1	Exostosin-1; Belongs to the glycosyltransferase 47 family. (501 aa)
	EMP2	Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
	MEF2C	Myocyte-specific enhancer factor 2C isoform X3. (433 aa)
	LEMD2	LEM domain-containing protein 2. (314 aa)
	ENSUMAP00000018664	annotation not available (401 aa)
	LRP2	Low-density lipoprotein receptor-related protein 2. (403 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN2	BMP4	ENSUMAP00000029358	ENSUMAP00000021648	Axin-2.	Bone morphogenetic protein 4.	0.526
AXIN2	ENSUMAP00000018664	ENSUMAP00000029358	ENSUMAP00000018664	Axin-2.	annotation not available	0.479
AXIN2	LRP2	ENSUMAP00000029358	ENSUMAP00000018712	Axin-2.	Low-density lipoprotein receptor-related protein 2.	0.479
BMP4	AXIN2	ENSUMAP00000021648	ENSUMAP00000029358	Bone morphogenetic protein 4.	Axin-2.	0.526
BMP4	BMPR1A	ENSUMAP00000021648	ENSUMAP00000019489	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.996
BMP4	MEF2C	ENSUMAP00000021648	ENSUMAP00000006803	Bone morphogenetic protein 4.	Myocyte-specific enhancer factor 2C isoform X3.	0.406
BMPR1A	BMP4	ENSUMAP00000019489	ENSUMAP00000021648	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.996
ENSUMAP00000018664	AXIN2	ENSUMAP00000018664	ENSUMAP00000029358	annotation not available	Axin-2.	0.479
LRP2	AXIN2	ENSUMAP00000018712	ENSUMAP00000029358	Low-density lipoprotein receptor-related protein 2.	Axin-2.	0.479
MEF2C	BMP4	ENSUMAP00000006803	ENSUMAP00000021648	Myocyte-specific enhancer factor 2C isoform X3.	Bone morphogenetic protein 4.	0.406