30 items (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	DHX9	ATP-dependent RNA helicase A. (1276 aa)
	MAEL	Protein maelstrom homolog. (442 aa)
	ZC3H10	Zinc finger CCCH domain-containing protein 10. (435 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (582 aa)
	ESR1	LOW QUALITY PROTEIN: estrogen receptor. (328 aa)
	TRUB1	LOW QUALITY PROTEIN: probable tRNA pseudouridine synthase 1. (337 aa)
	NCOR2	Nuclear receptor corepressor 2. (2249 aa)
	TIAL1	TIA1 cytotoxic granule associated RNA binding protein like 1. (375 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (461 aa)
	LIMD1	LIM domain-containing protein 1. (669 aa)
	NCOR1	Nuclear receptor corepressor 1-like. (1398 aa)
	LOC103658515	Nuclear receptor corepressor 1. (248 aa)
	FXR1	Fragile X mental retardation syndrome-related protein 1 isoform X3. (536 aa)
	BCDIN3D	pre-miRNA 5'-monophosphate methyltransferase. (284 aa)
	EGFR	Receptor protein-tyrosine kinase. (1191 aa)
	PUM1	LOW QUALITY PROTEIN: pumilio homolog 1. (1109 aa)
	FMR1	LOW QUALITY PROTEIN: fragile X mental retardation protein 1. (626 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	ZMPSTE24	Zinc metallopeptidase STE24. (276 aa)
	DDX5	Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (614 aa)
	ENSUMAP00000025353	annotation not available (182 aa)
	RIPK1	Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
	ZFP36	Tristetraprolin. (323 aa)
	LIN28B	Protein lin-28 homolog B isoform X1. (254 aa)
	PUM2	Pumilio RNA binding family member 2. (1063 aa)
	STAT3	Signal transducer and activator of transcription. (838 aa)
	ELAVL1	ELAV-like protein; Belongs to the RRM elav family. (344 aa)
	AJUBA	LIM domain-containing protein ajuba. (121 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AJUBA	ENSUMAP00000025353	ENSUMAP00000019181	ENSUMAP00000025353	LIM domain-containing protein ajuba.	annotation not available	0.428
AJUBA	LIMD1	ENSUMAP00000019181	ENSUMAP00000007327	LIM domain-containing protein ajuba.	LIM domain-containing protein 1.	0.939
AJUBA	LOC103658515	ENSUMAP00000019181	ENSUMAP00000009126	LIM domain-containing protein ajuba.	Nuclear receptor corepressor 1.	0.441
AJUBA	NCOR1	ENSUMAP00000019181	ENSUMAP00000009101	LIM domain-containing protein ajuba.	Nuclear receptor corepressor 1-like.	0.441
BCDIN3D	ZC3H10	ENSUMAP00000010364	ENSUMAP00000022983	pre-miRNA 5'-monophosphate methyltransferase.	Zinc finger CCCH domain-containing protein 10.	0.424
BMP4	LIN28B	ENSUMAP00000021648	ENSUMAP00000028799	Bone morphogenetic protein 4.	Protein lin-28 homolog B isoform X1.	0.410
BMP4	STAT3	ENSUMAP00000021648	ENSUMAP00000034771	Bone morphogenetic protein 4.	Signal transducer and activator of transcription.	0.453
DDX5	DHX9	ENSUMAP00000024443	ENSUMAP00000022533	Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family.	ATP-dependent RNA helicase A.	0.991
DDX5	ESR1	ENSUMAP00000024443	ENSUMAP00000002449	Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family.	LOW QUALITY PROTEIN: estrogen receptor.	0.793
DDX5	FMR1	ENSUMAP00000024443	ENSUMAP00000013932	Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family.	LOW QUALITY PROTEIN: fragile X mental retardation protein 1.	0.407
DDX5	FXR1	ENSUMAP00000024443	ENSUMAP00000009345	Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family.	Fragile X mental retardation syndrome-related protein 1 isoform X3.	0.513
DDX5	TP53	ENSUMAP00000024443	ENSUMAP00000023207	Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.705
DDX5	TRUB1	ENSUMAP00000024443	ENSUMAP00000002761	Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family.	LOW QUALITY PROTEIN: probable tRNA pseudouridine synthase 1.	0.495
DHX9	DDX5	ENSUMAP00000022533	ENSUMAP00000024443	ATP-dependent RNA helicase A.	Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family.	0.991
DHX9	EGFR	ENSUMAP00000022533	ENSUMAP00000012230	ATP-dependent RNA helicase A.	Receptor protein-tyrosine kinase.	0.447
DHX9	ELAVL1	ENSUMAP00000022533	ENSUMAP00000020228	ATP-dependent RNA helicase A.	ELAV-like protein; Belongs to the RRM elav family.	0.553
DHX9	ZFP36	ENSUMAP00000022533	ENSUMAP00000026830	ATP-dependent RNA helicase A.	Tristetraprolin.	0.459
EGFR	DHX9	ENSUMAP00000012230	ENSUMAP00000022533	Receptor protein-tyrosine kinase.	ATP-dependent RNA helicase A.	0.447
EGFR	ESR1	ENSUMAP00000012230	ENSUMAP00000002449	Receptor protein-tyrosine kinase.	LOW QUALITY PROTEIN: estrogen receptor.	0.871
EGFR	FMR1	ENSUMAP00000012230	ENSUMAP00000013932	Receptor protein-tyrosine kinase.	LOW QUALITY PROTEIN: fragile X mental retardation protein 1.	0.475