(55 nodes) Kidney morphogenesis network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LGR4	Leucine-rich repeat-containing G-protein coupled receptor 4. (905 aa)
	GREB1L	GREB1-like protein. (1776 aa)
	WT1	Wilms tumor protein isoform X1. (305 aa)
	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX. (329 aa)
	ENSUMAP00000025747	annotation not available (76 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
	ZMPSTE24	Zinc metallopeptidase STE24. (276 aa)
	KLHL3	Kelch-like protein 3. (607 aa)
	NPHP3	Nephrocystin-3. (1266 aa)
	GREM1	Gremlin. (232 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	CALB1	Calbindin 1. (261 aa)
	SIX1	Homeobox protein SIX1. (284 aa)
	SIX2	LOW QUALITY PROTEIN: homeobox protein SIX2. (267 aa)
	WWTR1	WW domain-containing transcription regulator protein 1. (397 aa)
	GPC3	Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (625 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	GLI3	Transcriptional activator GLI3. (524 aa)
	PTCH1	Protein patched homolog 1. (1388 aa)
	TMEM59L	LOW QUALITY PROTEIN: transmembrane protein 59-like. (352 aa)
	PAX8	Paired box protein Pax-8. (459 aa)
	GDNF	Glial cell line-derived neurotrophic factor. (241 aa)
	FRAS1	Extracellular matrix protein FRAS1. (3981 aa)
	GCNT4	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 isoform X4. (454 aa)
	SMO	Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (745 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (334 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	SALL1	LOW QUALITY PROTEIN: sal-like protein 1. (144 aa)
	BMP2	Bone morphogenetic protein 2 isoform X2. (395 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (461 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
	PKD2	Polycystin-2. (831 aa)
	GZF1	GDNF-inducible zinc finger protein 1 isoform X1. (715 aa)
	SMAD4	Mothers against decapentaplegic homolog. (546 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
	GREB1	LOW QUALITY PROTEIN: protein GREB1. (1897 aa)
	ENSUMAP00000001989	annotation not available (146 aa)
	HS2ST1	Heparan sulfate 2-O-sulfotransferase 1. (333 aa)
	HES1	Transcription factor HES-1. (166 aa)
	ILK	Integrin-linked protein kinase. (452 aa)
	WNK4	Serine/threonine-protein kinase WNK4. (1215 aa)
	TCF21	Transcription factor 21. (179 aa)
	LRRK2	LOW QUALITY PROTEIN: leucine-rich repeat serine/threonine-protein kinase 2. (2513 aa)
	ASXL1	Putative Polycomb group protein ASXL1. (1509 aa)
	CTNNBIP1	Catenin beta interacting protein 1. (81 aa)
	AHI1	LOW QUALITY PROTEIN: jouberin. (1133 aa)
	GCNT3	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3. (438 aa)
	DLG2	Disks large homolog 2 isoform X1. (843 aa)
	OSR1	Protein odd-skipped-related 1. (272 aa)
	NPNT	Nephronectin. (562 aa)
	LHX1	LOW QUALITY PROTEIN: LIM/homeobox protein Lhx1. (395 aa)
	GCNT1	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase. (428 aa)
	ADAMTS16	A disintegrin and metalloproteinase with thrombospondin motifs 16. (1201 aa)
	SOX8	Transcription factor SOX-8. (216 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHI1	NPHP3	ENSUMAP00000033367	ENSUMAP00000021996	LOW QUALITY PROTEIN: jouberin.	Nephrocystin-3.	0.434
ASXL1	WT1	ENSUMAP00000033551	ENSUMAP00000026810	Putative Polycomb group protein ASXL1.	Wilms tumor protein isoform X1.	0.490
BMP2	BMP4	ENSUMAP00000006638	ENSUMAP00000021648	Bone morphogenetic protein 2 isoform X2.	Bone morphogenetic protein 4.	0.928
BMP2	FGF1	ENSUMAP00000006638	ENSUMAP00000015805	Bone morphogenetic protein 2 isoform X2.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.458
BMP2	FGF10	ENSUMAP00000006638	ENSUMAP00000007657	Bone morphogenetic protein 2 isoform X2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.526
BMP2	FGF2	ENSUMAP00000006638	ENSUMAP00000005828	Bone morphogenetic protein 2 isoform X2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.729
BMP2	GREM1	ENSUMAP00000006638	ENSUMAP00000021750	Bone morphogenetic protein 2 isoform X2.	Gremlin.	0.948
BMP2	SMAD4	ENSUMAP00000006638	ENSUMAP00000003792	Bone morphogenetic protein 2 isoform X2.	Mothers against decapentaplegic homolog.	0.821
BMP4	BMP2	ENSUMAP00000021648	ENSUMAP00000006638	Bone morphogenetic protein 4.	Bone morphogenetic protein 2 isoform X2.	0.928
BMP4	FGF1	ENSUMAP00000021648	ENSUMAP00000015805	Bone morphogenetic protein 4.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.447
BMP4	FGF10	ENSUMAP00000021648	ENSUMAP00000007657	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.817
BMP4	FGF2	ENSUMAP00000021648	ENSUMAP00000005828	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.769
BMP4	GDNF	ENSUMAP00000021648	ENSUMAP00000010972	Bone morphogenetic protein 4.	Glial cell line-derived neurotrophic factor.	0.449
BMP4	GREM1	ENSUMAP00000021648	ENSUMAP00000021750	Bone morphogenetic protein 4.	Gremlin.	0.937
BMP4	PTCH1	ENSUMAP00000021648	ENSUMAP00000013120	Bone morphogenetic protein 4.	Protein patched homolog 1.	0.525
BMP4	SMAD4	ENSUMAP00000021648	ENSUMAP00000003792	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.866
BMP4	WNT1	ENSUMAP00000021648	ENSUMAP00000008598	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.478
DLG1	DLG2	ENSUMAP00000003680	ENSUMAP00000033110	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	Disks large homolog 2 isoform X1.	0.901
DLG2	DLG1	ENSUMAP00000033110	ENSUMAP00000003680	Disks large homolog 2 isoform X1.	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	0.901
ENSUMAP00000025747	GDNF	ENSUMAP00000025747	ENSUMAP00000010972	annotation not available	Glial cell line-derived neurotrophic factor.	0.566