STRINGSTRING
EPDR1 EPDR1 ENSUMAP00000015803 ENSUMAP00000015803 CACNA1C CACNA1C RYR2 RYR2 CACNB2 CACNB2 MYH6 MYH6 MYH7 MYH7 PARVA PARVA CACNA2D1 CACNA2D1 MYL6B MYL6B KCNE4 KCNE4 KCNH2 KCNH2 VIL1 VIL1 ROCK1 ROCK1 KCNE2 KCNE2 KCNE1 KCNE1 CACNA1D CACNA1D PDPN PDPN SCN3B SCN3B SCN1B SCN1B ENSUMAP00000001219 ENSUMAP00000001219 KCNJ8 KCNJ8 ABCC9 ABCC9 SCN2B SCN2B SCN4B SCN4B SGCD SGCD KCNJ5 KCNJ5 PKP2 PKP2 SHTN1 SHTN1 GSN GSN EMP2 EMP2 SCN5A SCN5A CCDC88C CCDC88C VILL VILL KCNQ1 KCNQ1 KCNA5 KCNA5 KCNJ2 KCNJ2 PIK3CA PIK3CA NUP155 NUP155 GJA5 GJA5 KCNE3 KCNE3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EPDR1Mammalian ependymin-related protein 1. (122 aa)
ENSUMAP00000015803annotation not available (807 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1104 aa)
RYR2Ryanodine receptor 2. (4923 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2. (613 aa)
MYH6LOW QUALITY PROTEIN: myosin-6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1909 aa)
MYH7LOW QUALITY PROTEIN: myosin-7-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1880 aa)
PARVAAlpha-parvin isoform X2. (356 aa)
CACNA2D1Voltage-dependent calcium channel subunit alpha-2/delta-1. (1049 aa)
MYL6BMyosin light chain 6B. (213 aa)
KCNE4Potassium voltage-gated channel subfamily E member 4. (80 aa)
KCNH2LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily H member 2. (790 aa)
VIL1Villin-1. (818 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
KCNE2Potassium voltage-gated channel subfamily E regulatory subunit 2. (138 aa)
KCNE1Potassium voltage-gated channel subfamily E member 1. (129 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2127 aa)
PDPNPodoplanin. (190 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (215 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (218 aa)
ENSUMAP00000001219annotation not available (80 aa)
KCNJ8Potassium voltage-gated channel subfamily J member 8. (424 aa)
ABCC9ATP-binding cassette sub-family C member 9 isoform X1. (1549 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (209 aa)
SCN4BSodium channel subunit beta-4. (226 aa)
SGCDDelta-sarcoglycan isoform X1. (289 aa)
KCNJ5G protein-activated inward rectifier potassium channel 4. (419 aa)
PKP2Plakophilin-2. (839 aa)
SHTN1Shootin-1. (623 aa)
GSNGelsolin isoform X1. (748 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2011 aa)
CCDC88CLOW QUALITY PROTEIN: protein Daple. (1918 aa)
VILLLOW QUALITY PROTEIN: villin-like protein. (575 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (410 aa)
KCNA5LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (583 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (428 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
NUP155Nuclear pore complex protein Nup155. (1391 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (99 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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