44 items (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EDN1	Endothelin-1. (202 aa)
	OSER1	Oxidative stress-responsive serine-rich protein 1. (292 aa)
	AQP1	Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
	PDCD10	Programmed cell death protein 10. (212 aa)
	ENSUMAP00000004324	annotation not available (106 aa)
	SRC	Tyrosine-protein kinase. (618 aa)
	PLEKHA1	Pleckstrin homology domain-containing family A member 1 isoform X1. (403 aa)
	SIGMAR1	Sigma non-opioid intracellular receptor 1. (223 aa)
	MAPK7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (264 aa)
	RNF112	RING finger protein 112. (425 aa)
	ZNF277	Zinc finger protein 277. (456 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1 isoform X2. (446 aa)
	HDAC6	LOW QUALITY PROTEIN: histone deacetylase 6. (976 aa)
	ENSUMAP00000010661	annotation not available (263 aa)
	ECT2	Protein ECT2. (641 aa)
	MAPK13	Mitogen-activated protein kinase. (373 aa)
	STK25	Serine/threonine-protein kinase 25. (422 aa)
	RELA	Transcription factor p65. (585 aa)
	RPS3	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (245 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (747 aa)
	NET1	Neuroepithelial cell-transforming gene 1 protein. (542 aa)
	SPHK1	LOW QUALITY PROTEIN: sphingosine kinase 1. (387 aa)
	ENSUMAP00000018377	annotation not available (92 aa)
	PPIF	Peptidyl-prolyl isomerase F (cyclophilin D). (105 aa)
	LOC103671894	Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (172 aa)
	NFE2L2	Nuclear factor erythroid 2-related factor 2 isoform X2. (590 aa)
	SETX	Probable helicase senataxin. (2692 aa)
	PCGF2	Polycomb group RING finger protein 2 isoform X1. (326 aa)
	ENSUMAP00000023946	annotation not available (124 aa)
	CAT	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (486 aa)
	ABL1	Tyrosine-protein kinase. (1135 aa)
	RIPK1	Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
	ANKZF1	Ankyrin repeat and zinc finger domain-containing protein 1 isoform X1. (789 aa)
	TRPA1	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1105 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (658 aa)
	ENSUMAP00000027960	annotation not available (155 aa)
	FXN	Frataxin, mitochondrial. (135 aa)
	IMPACT	Impact RWD domain protein. (300 aa)
	ANXA1	Annexin. (345 aa)
	RIPK3	Receptor-interacting serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. (487 aa)
	TNFAIP3	Tumor necrosis factor alpha-induced protein 3. (714 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1768 aa)
	PARK7	Parkinsonism associated deglycase. (189 aa)
	TRPM2	Transient receptor potential cation channel subfamily M member 2. (1524 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	MAPK13	ENSUMAP00000025680	ENSUMAP00000013829	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.464
CAT	ENSUMAP00000027960	ENSUMAP00000024880	ENSUMAP00000027960	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	annotation not available	0.594
CAT	PARK7	ENSUMAP00000024880	ENSUMAP00000033471	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Parkinsonism associated deglycase.	0.594
ECT2	ENSUMAP00000010661	ENSUMAP00000010685	ENSUMAP00000010661	Protein ECT2.	annotation not available	0.942
EDN1	SRC	ENSUMAP00000024701	ENSUMAP00000004515	Endothelin-1.	Tyrosine-protein kinase.	0.467
ENSUMAP00000010661	ECT2	ENSUMAP00000010661	ENSUMAP00000010685	annotation not available	Protein ECT2.	0.942
ENSUMAP00000018377	RELA	ENSUMAP00000018377	ENSUMAP00000014520	annotation not available	Transcription factor p65.	0.532
ENSUMAP00000027960	CAT	ENSUMAP00000027960	ENSUMAP00000024880	annotation not available	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	0.594
ENSUMAP00000027960	HDAC6	ENSUMAP00000027960	ENSUMAP00000010096	annotation not available	LOW QUALITY PROTEIN: histone deacetylase 6.	0.479
EZH2	PCGF2	ENSUMAP00000015687	ENSUMAP00000023463	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Polycomb group RING finger protein 2 isoform X1.	0.722
EZH2	RELA	ENSUMAP00000015687	ENSUMAP00000014520	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	Transcription factor p65.	0.411
EZH2	SIRT1	ENSUMAP00000015687	ENSUMAP00000009446	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	NAD-dependent protein deacetylase sirtuin-1 isoform X2.	0.707
HDAC6	ENSUMAP00000027960	ENSUMAP00000010096	ENSUMAP00000027960	LOW QUALITY PROTEIN: histone deacetylase 6.	annotation not available	0.479
HDAC6	PARK7	ENSUMAP00000010096	ENSUMAP00000033471	LOW QUALITY PROTEIN: histone deacetylase 6.	Parkinsonism associated deglycase.	0.479
HDAC6	SIRT1	ENSUMAP00000010096	ENSUMAP00000009446	LOW QUALITY PROTEIN: histone deacetylase 6.	NAD-dependent protein deacetylase sirtuin-1 isoform X2.	0.646
MAP3K5	PARK7	ENSUMAP00000033317	ENSUMAP00000033471	Mitogen-activated protein kinase kinase kinase 5.	Parkinsonism associated deglycase.	0.933
MAPK13	ABL1	ENSUMAP00000013829	ENSUMAP00000025680	Mitogen-activated protein kinase.	Tyrosine-protein kinase.	0.464
MAPK7	NFE2L2	ENSUMAP00000008142	ENSUMAP00000021462	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Nuclear factor erythroid 2-related factor 2 isoform X2.	0.913
MAPK7	SRC	ENSUMAP00000008142	ENSUMAP00000004515	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Tyrosine-protein kinase.	0.438
NFE2L2	MAPK7	ENSUMAP00000021462	ENSUMAP00000008142	Nuclear factor erythroid 2-related factor 2 isoform X2.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.913