(34 nodes) ERK1 and ERK2 cascade network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAPK3	Mitogen-activated protein kinase. (354 aa)
	MT3	Metallothionein 3. (68 aa)
	ENSUMAP00000001578	annotation not available (294 aa)
	NOD1	Nucleotide-binding oligomerization domain-containing protein 1. (263 aa)
	MAPK1	Mitogen-activated protein kinase. (363 aa)
	TLR4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
	SPRY1	Protein sprouty homolog 1 isoform X1. (311 aa)
	FLCN	Folliculin. (579 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	NOD2	Nucleotide-binding oligomerization domain-containing protein 2. (817 aa)
	KDR	LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1344 aa)
	C1QL4	Complement C1q-like protein 4. (111 aa)
	GRB10	Growth factor receptor-bound protein 10. (586 aa)
	ZFP36L1	Zinc finger protein 36, C3H1 type-like 1. (338 aa)
	CTSH	LOW QUALITY PROTEIN: pro-cathepsin H; Belongs to the peptidase C1 family. (295 aa)
	TBC1D10C	Carabin isoform X1. (423 aa)
	KARS1	Lysine--tRNA ligase. (625 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (315 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (240 aa)
	BRAF	Serine/threonine-protein kinase B-raf. (715 aa)
	RIPK2	LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 2. (512 aa)
	ENSUMAP00000021277	annotation not available (493 aa)
	ANKRD26	LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 26. (321 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (242 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (480 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1230 aa)
	IQGAP3	Ras GTPase-activating-like protein IQGAP3. (1601 aa)
	EDN1	Endothelin-1. (202 aa)
	ABL1	Tyrosine-protein kinase. (1135 aa)
	ITGAV	LOW QUALITY PROTEIN: integrin alpha-V; Belongs to the integrin alpha chain family. (1056 aa)
	HESX1	Homeobox expressed in ES cells 1. (181 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
	WNK4	Serine/threonine-protein kinase WNK4. (1215 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	MAPK1	ENSUMAP00000025680	ENSUMAP00000004216	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.437
ABL1	MAPK3	ENSUMAP00000025680	ENSUMAP00000014967	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.437
ANKRD26	ENSUMAP00000021277	ENSUMAP00000021284	ENSUMAP00000021277	LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 26.	annotation not available	0.670
BRAF	IQGAP3	ENSUMAP00000020492	ENSUMAP00000024533	Serine/threonine-protein kinase B-raf.	Ras GTPase-activating-like protein IQGAP3.	0.501
BRAF	MAPK1	ENSUMAP00000020492	ENSUMAP00000004216	Serine/threonine-protein kinase B-raf.	Mitogen-activated protein kinase.	0.851
BRAF	MAPK3	ENSUMAP00000020492	ENSUMAP00000014967	Serine/threonine-protein kinase B-raf.	Mitogen-activated protein kinase.	0.850
BRAF	SPRY2	ENSUMAP00000020492	ENSUMAP00000019974	Serine/threonine-protein kinase B-raf.	Sprouty RTK signaling antagonist 2.	0.949
EDN1	FGF2	ENSUMAP00000024701	ENSUMAP00000005828	Endothelin-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.645
EDN1	KDR	ENSUMAP00000024701	ENSUMAP00000007771	Endothelin-1.	LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.549
ENSUMAP00000001578	ENSUMAP00000021277	ENSUMAP00000001578	ENSUMAP00000021277	annotation not available	annotation not available	0.614
ENSUMAP00000021277	ANKRD26	ENSUMAP00000021277	ENSUMAP00000021284	annotation not available	LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 26.	0.670
ENSUMAP00000021277	ENSUMAP00000001578	ENSUMAP00000021277	ENSUMAP00000001578	annotation not available	annotation not available	0.614
FGF10	FGF18	ENSUMAP00000007657	ENSUMAP00000034256	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.527
FGF10	FGF2	ENSUMAP00000007657	ENSUMAP00000005828	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.498
FGF10	FGF23	ENSUMAP00000007657	ENSUMAP00000020276	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.637
FGF10	KDR	ENSUMAP00000007657	ENSUMAP00000007771	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.813
FGF18	FGF10	ENSUMAP00000034256	ENSUMAP00000007657	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.527
FGF18	FGF2	ENSUMAP00000034256	ENSUMAP00000005828	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.505
FGF18	FGF23	ENSUMAP00000034256	ENSUMAP00000020276	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.722
FGF18	KDR	ENSUMAP00000034256	ENSUMAP00000007771	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.816