STRINGSTRING
PARK2-2 PARK2-2 RNF146 RNF146 AMFR AMFR ZNRF2 ZNRF2 UBE2A UBE2A TRIM32 TRIM32 UBE2T UBE2T BFAR BFAR RNF152 RNF152 NEDD4L NEDD4L RNF126 RNF126 ITCH ITCH ENSUMAP00000006878 ENSUMAP00000006878 ENSUMAP00000007194 ENSUMAP00000007194 FBXO38 FBXO38 RNF34 RNF34 ENSUMAP00000015922 ENSUMAP00000015922 PARK2 PARK2 RNF115 RNF115 RNF5 RNF5 RNF8 RNF8 UBE2G1 UBE2G1 LOC103679172 LOC103679172 UBR5 UBR5 UBE2E1 UBE2E1 UBE2E2 UBE2E2 UBE2E2-2 UBE2E2-2 UBE3A UBE3A UBE2G2 UBE2G2 DTX3L DTX3L UBE2C UBE2C TNFAIP3 TNFAIP3 CUL3 CUL3 UBE2B UBE2B UBE2E3 UBE2E3 RFFL RFFL KLHL3 KLHL3 KBTBD7 KBTBD7 UBE2H UBE2H KBTBD6 KBTBD6 ZNRF1 ZNRF1 UBE3C UBE3C ARIH2 ARIH2 UBE2K UBE2K RNF187 RNF187 BTRC BTRC MARCHF6 MARCHF6 TOPORS TOPORS UBE2D1 UBE2D1 SYVN1 SYVN1 RNF216 RNF216 PELI1 PELI1 HACE1 HACE1 NMI NMI TTC3 TTC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PARK2-2E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (176 aa)
RNF146E3 ubiquitin-protein ligase RNF146. (360 aa)
AMFRE3 ubiquitin-protein ligase AMFR. (597 aa)
ZNRF2E3 ubiquitin-protein ligase ZNRF1/2. (71 aa)
UBE2AUbiquitin conjugating enzyme E2 A. (77 aa)
TRIM32E3 ubiquitin-protein ligase TRIM32. (654 aa)
UBE2TUbiquitin-conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (197 aa)
BFARBifunctional apoptosis regulator. (450 aa)
RNF152E3 ubiquitin-protein ligase RNF152. (203 aa)
NEDD4LE3 ubiquitin-protein ligase. (684 aa)
RNF126E3 ubiquitin-protein ligase RNF126. (360 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
ENSUMAP00000006878annotation not available (83 aa)
ENSUMAP00000007194annotation not available (103 aa)
FBXO38LOW QUALITY PROTEIN: F-box only protein 38. (1167 aa)
RNF34E3 ubiquitin-protein ligase RNF34 isoform X1. (376 aa)
ENSUMAP00000015922annotation not available (110 aa)
PARK2E3 ubiquitin-protein ligase parkin isoform X5. (153 aa)
RNF115E3 ubiquitin-protein ligase RNF115. (307 aa)
RNF5E3 ubiquitin-protein ligase RNF5. (180 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (430 aa)
UBE2G1Ubiquitin-conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
LOC103679172LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 D3-like. (139 aa)
UBR5LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase UBR5. (2732 aa)
UBE2E1Ubiquitin-conjugating enzyme E2 E1 isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa)
UBE2E2Ubiquitin-conjugating enzyme E2 E2 isoform X2; Belongs to the ubiquitin-conjugating enzyme family. (160 aa)
UBE2E2-2Ubiquitin conjugating enzyme E2 E2. (76 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (876 aa)
UBE2G2Ubiquitin-conjugating enzyme E2 G2 isoform X2; Belongs to the ubiquitin-conjugating enzyme family. (164 aa)
DTX3LE3 ubiquitin-protein ligase DTX3L. (657 aa)
UBE2CUbiquitin-conjugating enzyme E2 C isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (176 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (714 aa)
CUL3Cullin-3; Belongs to the cullin family. (746 aa)
UBE2BUbiquitin-conjugating enzyme E2 B isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (232 aa)
UBE2E3Ubiquitin-conjugating enzyme E2 E3; Belongs to the ubiquitin-conjugating enzyme family. (207 aa)
RFFLRing finger and FYVE like domain containing E3 ubiquitin protein ligase. (392 aa)
KLHL3Kelch-like protein 3. (607 aa)
KBTBD7Kelch repeat and BTB domain-containing protein 7. (679 aa)
UBE2HUbiquitin-conjugating enzyme E2 H isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
KBTBD6Kelch repeat and BTB domain-containing protein 6. (672 aa)
ZNRF1E3 ubiquitin-protein ligase ZNRF1. (138 aa)
UBE3CLOW QUALITY PROTEIN: ubiquitin-protein ligase E3C. (1061 aa)
ARIH2RBR-type E3 ubiquitin transferase. (491 aa)
UBE2KUbiquitin-conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (222 aa)
RNF187E3 ubiquitin-protein ligase RNF187. (298 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
MARCHF6LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase MARCH6. (882 aa)
TOPORSTOP1 binding arginine/serine rich protein. (1043 aa)
UBE2D1Ubiquitin-conjugating enzyme E2 D1 isoform X2; Belongs to the ubiquitin-conjugating enzyme family. (109 aa)
SYVN1E3 ubiquitin-protein ligase synoviolin. (573 aa)
RNF216E3 ubiquitin-protein ligase RNF216. (800 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
HACE1HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1. (875 aa)
NMIN-myc-interactor isoform X1. (336 aa)
TTC3LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase TTC3. (1999 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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