(17 nodes) Membrane repolarization network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	KCNE3	Potassium voltage-gated channel subfamily E regulatory subunit 3. (99 aa)
	KCNJ8	Potassium voltage-gated channel subfamily J member 8. (424 aa)
	KCNJ5	G protein-activated inward rectifier potassium channel 4. (419 aa)
	KCNIP4	Kv channel-interacting protein 4 isoform X1. (233 aa)
	SLC24A4	LOW QUALITY PROTEIN: sodium/potassium/calcium exchanger 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (606 aa)
	KCNQ1	Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (410 aa)
	KCNA5	LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (583 aa)
	KCNJ2	Potassium voltage-gated channel subfamily J member 2. (428 aa)
	KCNH7	Potassium voltage-gated channel subfamily H member 7. (1096 aa)
	ATP1B3	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (296 aa)
	ATP1B2	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (237 aa)
	KCNH6	Potassium voltage-gated channel subfamily H member 6 isoform X2. (957 aa)
	KCNE4	Potassium voltage-gated channel subfamily E member 4. (80 aa)
	KCNH2	LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily H member 2. (790 aa)
	KCNE2	Potassium voltage-gated channel subfamily E regulatory subunit 2. (138 aa)
	KCNE1	Potassium voltage-gated channel subfamily E member 1. (129 aa)
	KCNIP2	Kv channel-interacting protein 2. (263 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP1B2	ATP1B3	ENSUMAP00000023200	ENSUMAP00000018728	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.942
ATP1B3	ATP1B2	ENSUMAP00000018728	ENSUMAP00000023200	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.942
ATP1B3	KCNE4	ENSUMAP00000018728	ENSUMAP00000024700	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Potassium voltage-gated channel subfamily E member 4.	0.452
ATP1B3	KCNJ8	ENSUMAP00000018728	ENSUMAP00000001772	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	Potassium voltage-gated channel subfamily J member 8.	0.443
KCNA5	KCNE1	ENSUMAP00000010291	ENSUMAP00000027779	LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family.	Potassium voltage-gated channel subfamily E member 1.	0.567
KCNA5	KCNE2	ENSUMAP00000010291	ENSUMAP00000027774	LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family.	Potassium voltage-gated channel subfamily E regulatory subunit 2.	0.675
KCNA5	KCNE3	ENSUMAP00000010291	ENSUMAP00000014484	LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family.	Potassium voltage-gated channel subfamily E regulatory subunit 3.	0.553
KCNA5	KCNH2	ENSUMAP00000010291	ENSUMAP00000024840	LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family.	LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily H member 2.	0.571
KCNA5	KCNJ2	ENSUMAP00000010291	ENSUMAP00000010307	LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family.	Potassium voltage-gated channel subfamily J member 2.	0.638
KCNA5	KCNJ5	ENSUMAP00000010291	ENSUMAP00000003545	LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family.	G protein-activated inward rectifier potassium channel 4.	0.519
KCNE1	KCNA5	ENSUMAP00000027779	ENSUMAP00000010291	Potassium voltage-gated channel subfamily E member 1.	LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family.	0.567
KCNE1	KCNE2	ENSUMAP00000027779	ENSUMAP00000027774	Potassium voltage-gated channel subfamily E member 1.	Potassium voltage-gated channel subfamily E regulatory subunit 2.	0.403
KCNE1	KCNE3	ENSUMAP00000027779	ENSUMAP00000014484	Potassium voltage-gated channel subfamily E member 1.	Potassium voltage-gated channel subfamily E regulatory subunit 3.	0.717
KCNE1	KCNE4	ENSUMAP00000027779	ENSUMAP00000024700	Potassium voltage-gated channel subfamily E member 1.	Potassium voltage-gated channel subfamily E member 4.	0.636
KCNE1	KCNH2	ENSUMAP00000027779	ENSUMAP00000024840	Potassium voltage-gated channel subfamily E member 1.	LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily H member 2.	0.817
KCNE1	KCNH6	ENSUMAP00000027779	ENSUMAP00000023882	Potassium voltage-gated channel subfamily E member 1.	Potassium voltage-gated channel subfamily H member 6 isoform X2.	0.408
KCNE1	KCNJ2	ENSUMAP00000027779	ENSUMAP00000010307	Potassium voltage-gated channel subfamily E member 1.	Potassium voltage-gated channel subfamily J member 2.	0.644
KCNE1	KCNJ5	ENSUMAP00000027779	ENSUMAP00000003545	Potassium voltage-gated channel subfamily E member 1.	G protein-activated inward rectifier potassium channel 4.	0.527
KCNE1	KCNJ8	ENSUMAP00000027779	ENSUMAP00000001772	Potassium voltage-gated channel subfamily E member 1.	Potassium voltage-gated channel subfamily J member 8.	0.440
KCNE1	KCNQ1	ENSUMAP00000027779	ENSUMAP00000008258	Potassium voltage-gated channel subfamily E member 1.	Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family.	0.986