STRINGSTRING
SRF SRF ARHGAP42 ARHGAP42 TACR2 TACR2 KCNJ2 KCNJ2 TNFRSF1A TNFRSF1A P2RX1 P2RX1 PDE4B PDE4B ATP2A2 ATP2A2 ENSUMAP00000009397 ENSUMAP00000009397 CTTN CTTN CTNNA3 CTNNA3 DOCK4 DOCK4 NMU NMU P2RX4 P2RX4 LOC103663005 LOC103663005 GPER1 GPER1 KCNQ1 KCNQ1 TNNT3 TNNT3 TACR1 TACR1 MYL5 MYL5 ASB15 ASB15 ATP2B4 ATP2B4 MYOG MYOG UTRN UTRN SCN5A SCN5A PPP3CA PPP3CA ENSUMAP00000006329 ENSUMAP00000006329 LOC103656180 LOC103656180 TRPC3 TRPC3 ANXA6 ANXA6 ADRA1A ADRA1A SMAD4 SMAD4 DLG1 DLG1 PKP2 PKP2 PLN PLN LOC103665211 LOC103665211 GSK3A GSK3A SRL SRL ATP2B1 ATP2B1 SETD3 SETD3 TNNI1 TNNI1 CAV1 CAV1 CMYA5 CMYA5 TNNT2 TNNT2 TRPM4 TRPM4 HRC HRC SPX SPX ZC3H12A ZC3H12A MYLK2 MYLK2 CASQ1 CASQ1 ADRA1B ADRA1B MTPN MTPN PDE9A PDE9A ENSUMAP00000035418 ENSUMAP00000035418 ADA ADA TNNC2 TNNC2 MEF2A MEF2A BECN1 BECN1 TNNT1 TNNT1 TNNI3 TNNI3 TWF1 TWF1 PROK2 PROK2 DLG2 DLG2 ADRA2A ADRA2A DMPK DMPK MYMK MYMK FKBP1B FKBP1B NPNT NPNT JUP JUP ENSUMAP00000030969 ENSUMAP00000030969 FBXO32 FBXO32 TNFRSF1B TNFRSF1B TNNC1 TNNC1 BMP10 BMP10 PRKCA PRKCA ANKRD44 ANKRD44 ENSUMAP00000028231 ENSUMAP00000028231 FOXO3 FOXO3 ROCK1 ROCK1 LMCD1 LMCD1 CAV3 CAV3 PRKAG3 PRKAG3 LMNA LMNA ANKRD28 ANKRD28 EDN1 EDN1 RANGRF RANGRF ZDHHC21 ZDHHC21 SCN4A SCN4A TIFAB TIFAB DMD DMD PVALEF PVALEF PARP1 PARP1 SGCA SGCA GTF2IRD1 GTF2IRD1 MYH6 MYH6 TMEM38B TMEM38B KCNMA1 KCNMA1 SPHK1 SPHK1 RYR2 RYR2 SEPN1 SEPN1 ENSUMAP00000017080 ENSUMAP00000017080 CAMK2G CAMK2G CHRM3 CHRM3 GRK2 GRK2 ADRA2B ADRA2B SLC9A1 SLC9A1 ACTN3 ACTN3 CASQ2 CASQ2 HDAC4 HDAC4 ENSUMAP00000015139 ENSUMAP00000015139 PRKG1 PRKG1 GJA5 GJA5 PI16 PI16 GLRX3 GLRX3 ATP2A1 ATP2A1 PDE4D PDE4D ENSUMAP00000011982 ENSUMAP00000011982
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SRFSerum response factor. (446 aa)
ARHGAP42Rho GTPase-activating protein 42. (873 aa)
TACR2substance-K receptor; Belongs to the G-protein coupled receptor 1 family. (377 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (428 aa)
TNFRSF1ALOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A. (507 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
PDE4BPhosphodiesterase. (676 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (941 aa)
ENSUMAP00000009397annotation not available (194 aa)
CTTNSrc substrate cortactin. (512 aa)
CTNNA3Catenin alpha-3. (545 aa)
DOCK4Dedicator of cytokinesis protein 4; Belongs to the DOCK family. (1970 aa)
NMUneuromedin-U. (149 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (403 aa)
LOC103663005Serine/threonine-protein kinase TNNI3K isoform X2. (815 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (410 aa)
TNNT3Troponin T, fast skeletal muscle. (260 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
MYL5Myosin light chain 5. (172 aa)
ASB15LOW QUALITY PROTEIN: ankyrin repeat and SOCS box protein 15. (575 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
MYOGMyogenin. (208 aa)
UTRNLOW QUALITY PROTEIN: utrophin. (2015 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2011 aa)
PPP3CASerine/threonine-protein phosphatase. (461 aa)
ENSUMAP00000006329annotation not available (610 aa)
LOC103656180LOW QUALITY PROTEIN: protein C10. (192 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (848 aa)
ANXA6Annexin. (704 aa)
ADRA1Aalpha-1A adrenergic receptor isoform X1. (467 aa)
SMAD4Mothers against decapentaplegic homolog. (546 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
PKP2Plakophilin-2. (839 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
LOC103665211Mothers against decapentaplegic homolog. (244 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (417 aa)
SRLSarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (811 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
SETD3Protein-histidine N-methyltransferase. (604 aa)
TNNI1LOW QUALITY PROTEIN: troponin I, slow skeletal muscle. (185 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
CMYA5Cardiomyopathy-associated protein 5. (4023 aa)
TNNT2Troponin T, cardiac muscle isoform X2. (215 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1006 aa)
HRCSarcoplasmic reticulum histidine-rich calcium-binding protein. (704 aa)
SPXSpexin. (110 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (582 aa)
MYLK2Myosin light chain kinase 2, skeletal/cardiac muscle. (607 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (400 aa)
ADRA1Balpha-1B adrenergic receptor. (427 aa)
MTPNMyotrophin. (118 aa)
PDE9APhosphodiesterase. (457 aa)
ENSUMAP00000035418annotation not available (107 aa)
ADAAdenosine deaminase isoform X4. (423 aa)
TNNC2Troponin C, skeletal muscle. (180 aa)
MEF2AMyocyte-specific enhancer factor 2A. (466 aa)
BECN1Beclin-1 isoform X1. (555 aa)
TNNT1Troponin T, slow skeletal muscle. (256 aa)
TNNI3Troponin I, cardiac muscle isoform X2. (205 aa)
TWF1Twinfilin-1. (352 aa)
PROK2Prokineticin-2 isoform X2. (123 aa)
DLG2Disks large homolog 2 isoform X1. (843 aa)
ADRA2AAdrenoceptor alpha 2A. (418 aa)
DMPKMyotonin-protein kinase isoform X1; Belongs to the protein kinase superfamily. (454 aa)
MYMKMyomaker, myoblast fusion factor. (221 aa)
FKBP1BPeptidylprolyl isomerase. (79 aa)
NPNTNephronectin. (562 aa)
JUPJunction plakoglobin. (716 aa)
ENSUMAP00000030969annotation not available (251 aa)
FBXO32F-box only protein 32. (329 aa)
TNFRSF1BLOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1B. (313 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles. (188 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
ANKRD44Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1. (1083 aa)
ENSUMAP00000028231annotation not available (95 aa)
FOXO3Forkhead box protein O3. (453 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
LMCD1LIM and cysteine-rich domains protein 1. (363 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (491 aa)
LMNALamin A/C. (576 aa)
ANKRD28Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1. (1083 aa)
EDN1Endothelin-1. (202 aa)
RANGRFRan guanine nucleotide release factor. (175 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
SCN4ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1827 aa)
TIFABTRAF-interacting protein with FHA domain-containing protein B. (201 aa)
DMDLOW QUALITY PROTEIN: dystrophin. (2187 aa)
PVALEFParvalbumin like EF-hand containing. (169 aa)
PARP1Poly [ADP-ribose] polymerase. (963 aa)
SGCAAlpha-sarcoglycan. (418 aa)
GTF2IRD1LOW QUALITY PROTEIN: general transcription factor II-I repeat domain-containing protein 1. (1005 aa)
MYH6LOW QUALITY PROTEIN: myosin-6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1909 aa)
TMEM38BTrimeric intracellular cation channel type B. (291 aa)
KCNMA1Calcium-activated potassium channel subunit alpha-1. (1117 aa)
SPHK1LOW QUALITY PROTEIN: sphingosine kinase 1. (387 aa)
RYR2Ryanodine receptor 2. (4923 aa)
SEPN1LOW QUALITY PROTEIN: selenoprotein N. (66 aa)
ENSUMAP00000017080annotation not available (106 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma. (579 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (552 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (636 aa)
ADRA2BLOW QUALITY PROTEIN: alpha-2B adrenergic receptor. (463 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (813 aa)
ACTN3Alpha-actinin-3. (925 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (411 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1142 aa)
ENSUMAP00000015139annotation not available (194 aa)
PRKG1cGMP-dependent protein kinase 1. (472 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
PI16LOW QUALITY PROTEIN: peptidase inhibitor 16. (305 aa)
GLRX3Glutaredoxin 3. (384 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1224 aa)
PDE4DPhosphodiesterase. (585 aa)
ENSUMAP00000011982annotation not available (136 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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