STRINGSTRING
SOBP SOBP CTHRC1 CTHRC1 GNGT1 GNGT1 HESX1 HESX1 PAX6 PAX6 COL5A2 COL5A2 EFEMP1 EFEMP1 ENSUMAP00000025747 ENSUMAP00000025747 EYA1 EYA1 RARB RARB THRB THRB CNTF CNTF HPN HPN BLOC1S5 BLOC1S5 TFAP2A TFAP2A EDN1 EDN1 PROX1 PROX1 TCAP TCAP TIFAB TIFAB MFSD2A MFSD2A FRZB FRZB OSR2 OSR2 NF2 NF2 PRKRA PRKRA OTX2 OTX2 MFAP5 MFAP5 GDF11 GDF11 ZEB1 ZEB1 BMP4 BMP4 EDNRA EDNRA CALB1 CALB1 SP3 SP3 MAN2A1 MAN2A1 MYO6 MYO6 EPHB1 EPHB1 HIPK2 HIPK2 DVL2 DVL2 FGF9 FGF9 NF1 NF1 SPRY2 SPRY2 INSIG1 INSIG1 SHH SHH GJB6 GJB6 ATF4 ATF4 ROM1 ROM1 FBN1 FBN1 LRP5 LRP5 SIX1 SIX1 ENSUMAP00000018722 ENSUMAP00000018722 HIF1A HIF1A CHD7 CHD7 GNAT2 GNAT2 EPHB2 EPHB2 SLC44A4 SLC44A4 INSIG2 INSIG2 PLS1 PLS1 GRHL3 GRHL3 HIPK1 HIPK1 CABP4 CABP4 SIX2 SIX2 RING1 RING1 MEGF11 MEGF11 CLRN1 CLRN1 LOC103665481 LOC103665481 LCTL LCTL FAT1 FAT1 TDRD7 TDRD7 PRKCI PRKCI NIPBL NIPBL PHACTR4 PHACTR4 MAPK3 MAPK3 TBX3 TBX3 GRXCR2 GRXCR2 TULP1 TULP1 LHFPL5 LHFPL5 BCAR3 BCAR3 RARG RARG GLI3 GLI3 RP1 RP1 NR2E3 NR2E3 PTK7 PTK7 DLL1 DLL1 JAG1 JAG1 STRC STRC USH1G USH1G ENSUMAP00000010835 ENSUMAP00000010835 ENSUMAP00000010549 ENSUMAP00000010549 BBS4 BBS4 NOTCH2 NOTCH2 SDK2 SDK2 SDK1 SDK1 MYPN MYPN TSHR TSHR WHRN WHRN FAT3 FAT3 TTC8 TTC8 WNT1 WNT1 KCNQ1 KCNQ1 KDR KDR FGF10 FGF10 KDM2B KDM2B FOXG1 FOXG1 STRA6 STRA6 AGTPBP1 AGTPBP1 NTRK2 NTRK2 TSHZ1 TSHZ1 TMIE TMIE PTPRQ PTPRQ LRRC1 LRRC1 LOC103656180 LOC103656180 PDE6C PDE6C RPGRIP1 RPGRIP1 MAPK1 MAPK1 CLRN2 CLRN2 TSPAN12 TSPAN12 PROM1 PROM1 RPGRIP1L RPGRIP1L IMPG2 IMPG2 AQP1 AQP1 CDON CDON PITX2 PITX2 LOC103682075 LOC103682075 COL8A2 COL8A2 ENSUMAP00000002173 ENSUMAP00000002173 COL8A1 COL8A1 BCR BCR TBC1D20 TBC1D20 CHRNA9 CHRNA9 KCNQ4 KCNQ4 WDR19 WDR19 SEC24B SEC24B SCRIB SCRIB FASLG FASLG LRIG3 LRIG3 RIPOR2 RIPOR2 ENSUMAP00000028342 ENSUMAP00000028342 FRS2 FRS2 WDPCP WDPCP SOX8 SOX8 MFAP2 MFAP2 TTC39C TTC39C DLX6 DLX6 DLX5 DLX5 ENSUMAP00000029735 ENSUMAP00000029735 ATP6V1B1 ATP6V1B1 ZHX2 ZHX2 GNAT1 GNAT1 RORB RORB MFN2 MFN2 LHX1 LHX1 FZD3 FZD3 CYP26B1 CYP26B1 INTU INTU PDZD7-2 PDZD7-2 PDZD7 PDZD7 TPRN TPRN OSR1 OSR1 THY1 THY1 MFRP MFRP USH1C USH1C LRIG1 LRIG1 AHI1 AHI1 FOXI1 FOXI1 RDH13 RDH13 HMGN1 HMGN1 DZANK1 DZANK1 STAT3 STAT3 ALDH1A3 ALDH1A3 CRB1 CRB1 CRYAA CRYAA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOBPSine oculis-binding protein homolog. (577 aa)
CTHRC1LOW QUALITY PROTEIN: collagen triple helix repeat-containing protein 1. (113 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (104 aa)
HESX1Homeobox expressed in ES cells 1. (181 aa)
PAX6Paired box protein Pax-6 isoform X2. (450 aa)
COL5A2Collagen alpha-2(V) chain. (1165 aa)
EFEMP1EGF-containing fibulin-like extracellular matrix protein 1. (501 aa)
ENSUMAP00000025747annotation not available (76 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
RARBRetinoic acid receptor beta-like. (441 aa)
THRBThyroid hormone receptor beta. (546 aa)
CNTFCiliary neurotrophic factor. (200 aa)
HPNSerine protease hepsin; Belongs to the peptidase S1 family. (237 aa)
BLOC1S5Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). (191 aa)
TFAP2ALOW QUALITY PROTEIN: transcription factor AP-2-alpha. (494 aa)
EDN1Endothelin-1. (202 aa)
PROX1Prospero homeobox protein 1. (737 aa)
TCAPTelethonin. (167 aa)
TIFABTRAF-interacting protein with FHA domain-containing protein B. (201 aa)
MFSD2ASodium-dependent lysophosphatidylcholine symporter 1. (524 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
OSR2Odd-skipped related transciption factor 2. (276 aa)
NF2LOW QUALITY PROTEIN: merlin. (595 aa)
PRKRAInterferon-inducible double-stranded RNA-dependent protein kinase activator A. (288 aa)
OTX2Homeobox protein OTX2 isoform X1. (297 aa)
MFAP5Microfibrillar-associated protein 5 isoform X1. (170 aa)
GDF11Growth/differentiation factor 11. (432 aa)
ZEB1Zinc finger E-box-binding homeobox 1. (1086 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
CALB1Calbindin 1. (261 aa)
SP3Transcription factor Sp3. (727 aa)
MAN2A1Alpha-mannosidase. (1148 aa)
MYO6Unconventional myosin-VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1245 aa)
EPHB1Ephrin type-B receptor 1. (979 aa)
HIPK2Homeodomain-interacting protein kinase 2 isoform X3. (1162 aa)
DVL2LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2. (391 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NF1Neurofibromin. (2862 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (247 aa)
SHHSonic hedgehog protein. (168 aa)
GJB6Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (261 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
ROM1Retinal outer segment membrane protein 1. (371 aa)
FBN1Fibrillin-1. (2958 aa)
LRP5Low-density lipoprotein receptor-related protein 5. (1602 aa)
SIX1Homeobox protein SIX1. (284 aa)
ENSUMAP00000018722annotation not available (372 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X2. (823 aa)
CHD7chromodomain-helicase-DNA-binding protein 7. (2976 aa)
GNAT2Guanine nucleotide-binding protein G(T) subunit alpha-2. (351 aa)
EPHB2Ephrin type-B receptor 2. (1056 aa)
SLC44A4Choline transporter-like protein 4; Belongs to the CTL (choline transporter-like) family. (707 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (229 aa)
PLS1Plastin-1 isoform X1. (629 aa)
GRHL3Grainyhead-like protein 3 homolog isoform X1. (700 aa)
HIPK1Homeodomain-interacting protein kinase 1. (1199 aa)
CABP4Calcium-binding protein 4. (278 aa)
SIX2LOW QUALITY PROTEIN: homeobox protein SIX2. (267 aa)
RING1E3 ubiquitin-protein ligase RING1. (406 aa)
MEGF11Multiple epidermal growth factor-like domains protein 11. (989 aa)
CLRN1Clarin-1. (232 aa)
LOC103665481Putative Bcl-2 homologous antagonist/killer 2. (349 aa)
LCTLLactase-like protein; Belongs to the glycosyl hydrolase 1 family. (569 aa)
FAT1LOW QUALITY PROTEIN: protocadherin Fat 1. (4623 aa)
TDRD7Tudor domain-containing protein 7 isoform X1. (1098 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (569 aa)
NIPBLNipped-B protein. (2805 aa)
PHACTR4Phosphatase and actin regulator. (706 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
TBX3LOW QUALITY PROTEIN: T-box transcription factor TBX3. (130 aa)
GRXCR2Glutaredoxin domain-containing cysteine-rich protein 2. (248 aa)
TULP1Tubby-like protein; Belongs to the TUB family. (518 aa)
LHFPL5Tetraspan membrane protein of hair cell stereocilia. (237 aa)
BCAR3Breast cancer anti-estrogen resistance protein 3. (757 aa)
RARGRetinoic acid receptor gamma isoform X1. (458 aa)
GLI3Transcriptional activator GLI3. (524 aa)
RP1Oxygen-regulated protein 1. (1361 aa)
NR2E3Photoreceptor-specific nuclear receptor. (258 aa)
PTK7Inactive tyrosine-protein kinase 7; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1081 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (695 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
STRCStereocilin. (1765 aa)
USH1GUsher syndrome type-1G protein. (236 aa)
ENSUMAP00000010835annotation not available (213 aa)
ENSUMAP00000010549annotation not available (144 aa)
BBS4Bardet-Biedl syndrome 4 protein isoform X2. (325 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (2444 aa)
SDK2Protein sidekick-2. (2077 aa)
SDK1Protein sidekick-1. (2042 aa)
MYPNMyopalladin isoform X1. (1318 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (756 aa)
WHRNWhirlin. (798 aa)
FAT3FAT atypical cadherin 3. (4555 aa)
TTC8Tetratricopeptide repeat protein 8 isoform X1. (505 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (334 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (410 aa)
KDRLOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1344 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
KDM2BLOW QUALITY PROTEIN: lysine-specific demethylase 2B. (685 aa)
FOXG1Forkhead box protein G1. (221 aa)
STRA6LOW QUALITY PROTEIN: stimulated by retinoic acid gene 6 protein homolog. (630 aa)
AGTPBP1Cytosolic carboxypeptidase 1. (1227 aa)
NTRK2BDNF/NT-3 growth factors receptor. (466 aa)
TSHZ1LOW QUALITY PROTEIN: teashirt homolog 1. (1052 aa)
TMIETransmembrane inner ear expressed protein. (166 aa)
PTPRQProtein tyrosine phosphatase receptor type Q. (2318 aa)
LRRC1Leucine-rich repeat-containing protein 1. (493 aa)
LOC103656180LOW QUALITY PROTEIN: protein C10. (192 aa)
PDE6CPhosphodiesterase. (834 aa)
RPGRIP1LOW QUALITY PROTEIN: X-linked retinitis pigmentosa GTPase regulator-interacting protein 1. (1149 aa)
MAPK1Mitogen-activated protein kinase. (363 aa)
CLRN2Clarin-2. (232 aa)
TSPAN12Tetraspanin. (305 aa)
PROM1Prominin-1 isoform X1. (839 aa)
RPGRIP1LLOW QUALITY PROTEIN: protein fantom. (1260 aa)
IMPG2Interphotoreceptor matrix proteoglycan 2. (1230 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
CDONCell adhesion molecule-related/down-regulated by oncogenes isoform X1. (1271 aa)
PITX2Homeobox protein. (325 aa)
LOC103682075Segment polarity protein dishevelled homolog DVL-1-like. (893 aa)
COL8A2LOW QUALITY PROTEIN: collagen alpha-2(VIII) chain. (600 aa)
ENSUMAP00000002173annotation not available (2738 aa)
COL8A1Collagen alpha-1(VIII) chain isoform X1. (744 aa)
BCRBCR activator of RhoGEF and GTPase. (1162 aa)
TBC1D20TBC1 domain family member 20. (394 aa)
CHRNA9Neuronal acetylcholine receptor subunit alpha-9. (478 aa)
KCNQ4Potassium voltage-gated channel subfamily KQT member 4. (262 aa)
WDR19WD repeat-containing protein 19. (1283 aa)
SEC24BProtein transport protein Sec24B. (1144 aa)
SCRIBLOW QUALITY PROTEIN: protein scribble homolog. (844 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (269 aa)
LRIG3Leucine-rich repeats and immunoglobulin-like domains protein 3. (1026 aa)
RIPOR2Protein FAM65B. (974 aa)
ENSUMAP00000028342annotation not available (97 aa)
FRS2Fibroblast growth factor receptor substrate 2. (507 aa)
WDPCPLOW QUALITY PROTEIN: WD repeat-containing and planar cell polarity effector protein fritz homolog. (690 aa)
SOX8Transcription factor SOX-8. (216 aa)
MFAP2Microfibrillar-associated protein 2. (156 aa)
TTC39CTetratricopeptide repeat protein 39C. (522 aa)
DLX6Homeobox protein DLX-6. (167 aa)
DLX5Homeobox protein DLX-5. (285 aa)
ENSUMAP00000029735annotation not available (98 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (509 aa)
ZHX2Zinc fingers and homeoboxes protein 2. (840 aa)
GNAT1LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(T) subunit alpha-1. (337 aa)
RORBLOW QUALITY PROTEIN: nuclear receptor ROR-beta. (467 aa)
MFN2Mitofusin-2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
LHX1LOW QUALITY PROTEIN: LIM/homeobox protein Lhx1. (395 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
CYP26B1Cytochrome P450 26B1; Belongs to the cytochrome P450 family. (304 aa)
INTUProtein inturned. (938 aa)
PDZD7-2PDZ domain-containing protein 7. (154 aa)
PDZD7LOW QUALITY PROTEIN: PDZ domain-containing protein 7. (538 aa)
TPRNTaperin. (409 aa)
OSR1Protein odd-skipped-related 1. (272 aa)
THY1Thy-1 membrane glycoprotein. (161 aa)
MFRPMembrane frizzled-related protein. (580 aa)
USH1CLOW QUALITY PROTEIN: harmonin. (853 aa)
LRIG1Leucine-rich repeats and immunoglobulin-like domains protein 1. (1026 aa)
AHI1LOW QUALITY PROTEIN: jouberin. (1133 aa)
FOXI1Forkhead box protein I1 isoform X1. (378 aa)
RDH13Retinol dehydrogenase 13; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (396 aa)
HMGN1Non-histone chromosomal protein HMG-14. (61 aa)
DZANK1LOW QUALITY PROTEIN: double zinc ribbon and ankyrin repeat-containing protein 1. (764 aa)
STAT3Signal transducer and activator of transcription. (838 aa)
ALDH1A3Aldehyde dehydrogenase family 1 member A3; Belongs to the aldehyde dehydrogenase family. (555 aa)
CRB1Protein crumbs homolog 1. (1365 aa)
CRYAAAlpha-crystallin A chain; Belongs to the small heat shock protein (HSP20) family. (177 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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