STRINGSTRING
MDM2 MDM2 ENSUMAP00000030897 ENSUMAP00000030897 CLTC CLTC KEAP1 KEAP1 NCOA3 NCOA3 TEAD2 TEAD2 ENSUMAP00000002305 ENSUMAP00000002305 HSP90AA1 HSP90AA1 HSP90AB1 HSP90AB1 AP2A2 AP2A2 RRM1 RRM1 CLTCL1 CLTCL1 NUMA1 NUMA1 DFFB DFFB EZR EZR HSPA2 HSPA2 LOC103672401 LOC103672401 TP53 TP53 RB1 RB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
ENSUMAP00000030897annotation not available (310 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
KEAP1Kelch-like ECH-associated protein 1. (579 aa)
NCOA3Nuclear receptor coactivator. (1435 aa)
TEAD2Transcriptional enhancer factor TEF-4. (440 aa)
ENSUMAP00000002305annotation not available (122 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
HSP90AB1Heat shock protein HSP 90-beta. (699 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (946 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (790 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1673 aa)
NUMA1Nuclear mitotic apparatus protein 1 isoform X1. (2143 aa)
DFFBDNAation factor subunit beta. (314 aa)
EZREzrin isoform X1. (629 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (636 aa)
LOC103672401LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like. (91 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
RB1Retinoblastoma-associated protein. (920 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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