STRINGSTRING
PARK2-2 PARK2-2 SLC1A3 SLC1A3 ENSUMAP00000015922 ENSUMAP00000015922 CCDC180 CCDC180 PARK2 PARK2 LOC103678492 LOC103678492 CACNA1C CACNA1C SLC15A3 SLC15A3 ENSUMAP00000015803 ENSUMAP00000015803 LOC103672916 LOC103672916 SLC29A2 SLC29A2 TFR2 TFR2 SLC6A4 SLC6A4 SLC9A7 SLC9A7 SLC12A1 SLC12A1 SLC1A2 SLC1A2 ACSL3 ACSL3 SLC1A1 SLC1A1 KCNH2 KCNH2 PARK7 PARK7 SLC15A1 SLC15A1 SLC2A10 SLC2A10 SLC12A5 SLC12A5 SLC12A8 SLC12A8 TRPM2 TRPM2 SLC6A1 SLC6A1 SLC6A11 SLC6A11 STEAP4 STEAP4 ATP1B1 ATP1B1 SLC7A1 SLC7A1 CACNA1E CACNA1E ATP1B2 ATP1B2 SLC12A6 SLC12A6 SLC39A5 SLC39A5 SLC12A2 SLC12A2 KCNJ13 KCNJ13 SLC7A11 SLC7A11 LRRC8E LRRC8E SLC27A2 SLC27A2 CACNA1G CACNA1G KCNJ4 KCNJ4 SLC3A2 SLC3A2 SLC5A2 SLC5A2 GFAP GFAP SLC7A8 SLC7A8 SLC6A13 SLC6A13 ENSUMAP00000019341 ENSUMAP00000019341 CD36 CD36 ATP12A ATP12A ATP1B3 ATP1B3 LRP2 LRP2 ENSUMAP00000018664 ENSUMAP00000018664 ACSL1 ACSL1 STEAP3 STEAP3 SLC39A12 SLC39A12 SLC8A1 SLC8A1 SLC9A9 SLC9A9 TSPO2 TSPO2 TREML1 TREML1 TREM2 TREM2 SLC46A1 SLC46A1 TRPV6 TRPV6 STEAP2 STEAP2 SLC12A4 SLC12A4 SLC39A4 SLC39A4 SLC9A5 SLC9A5 ATP4A ATP4A KCNE2 KCNE2 CACNA1D CACNA1D ENSUMAP00000027960 ENSUMAP00000027960 SLC39A10 SLC39A10 LRRC8A LRRC8A ATP4B ATP4B SLC9A2 SLC9A2 SLC9A4 SLC9A4 HFE HFE SLC1A4 SLC1A4 SLC6A3 SLC6A3 SLC12A7 SLC12A7 SLC5A6 SLC5A6 SLC27A4 SLC27A4 SLC9A3 SLC9A3 SLC1A7 SLC1A7 FAM155A FAM155A RPS6KB1 RPS6KB1 KCNJ11 KCNJ11 SLC1A5 SLC1A5 SLC8A2 SLC8A2 SLC9A6 SLC9A6 SLC8A3 SLC8A3 SCNN1G SCNN1G SLC18A1 SLC18A1 SCN8A SCN8A SLC11A2 SLC11A2 TRPV3 TRPV3 TRPV1 TRPV1 SLC7A5 SLC7A5 FOLR1 FOLR1 KCNJ2 KCNJ2 KCNJ16 KCNJ16 SCNN1A SCNN1A CACNA1F CACNA1F TRPV2 TRPV2 KCNQ1 KCNQ1 KCNJ3 KCNJ3 ADGRV1 ADGRV1 SCN5A SCN5A SLC29A1 SLC29A1 STRA6 STRA6 SLC39A8 SLC39A8 SLC24A4 SLC24A4 SLC39A14 SLC39A14 KCNJ12 KCNJ12 SCN11A SCN11A SLC6A20 SLC6A20 SLC9C1 SLC9C1 SLC27A5 SLC27A5 SLC1A6 SLC1A6 SLC36A1 SLC36A1 GRM1 GRM1 SLC18A2 SLC18A2 KCNJ5 KCNJ5 KCNJ1 KCNJ1 ATP1A3 ATP1A3 TRPV4 TRPV4 IL10RA IL10RA SLC39A6 SLC39A6 SLC6A2 SLC6A2 CACNA1S CACNA1S LRSAM1 LRSAM1 KCNJ8 KCNJ8 TRPM4 TRPM4 SPX SPX LRRC8C LRRC8C KCNJ10 KCNJ10 ATP1A2 ATP1A2 SLC12A3 SLC12A3 ATP1A4 ATP1A4 KCNJ15 KCNJ15 KCNJ6 KCNJ6 SLC15A4 SLC15A4 SLC7A3 SLC7A3 SLC9A1 SLC9A1 TRPV5 TRPV5 SLC22A1 SLC22A1 SLC22A2 SLC22A2 SLC22A3 SLC22A3 SLC27A1 SLC27A1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PARK2-2E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (176 aa)
SLC1A3Amino acid transporter. (542 aa)
ENSUMAP00000015922annotation not available (110 aa)
CCDC180LOW QUALITY PROTEIN: coiled-coil domain-containing protein 180. (1597 aa)
PARK2E3 ubiquitin-protein ligase parkin isoform X5. (153 aa)
LOC103678492Stimulated by retinoic acid gene 6 protein-like. (622 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1104 aa)
SLC15A3Solute carrier family 15 member 3. (394 aa)
ENSUMAP00000015803annotation not available (807 aa)
LOC103672916Cationic amino acid transporter 3-like. (625 aa)
SLC29A2Equilibrative nucleoside transporter 2. (458 aa)
TFR2LOW QUALITY PROTEIN: transferrin receptor protein 2. (780 aa)
SLC6A4Sodium-dependent serotonin transporter. (677 aa)
SLC9A7Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (621 aa)
SLC12A1LOW QUALITY PROTEIN: solute carrier family 12 member 1. (1101 aa)
SLC1A2Amino acid transporter. (599 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
SLC1A1Amino acid transporter. (506 aa)
KCNH2LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily H member 2. (790 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
SLC15A1Solute carrier family 15 member 1. (702 aa)
SLC2A10Solute carrier family 2, facilitated glucose transporter member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (597 aa)
SLC12A5Solute carrier family 12 member 5. (1101 aa)
SLC12A8Solute carrier family 12 member 8. (713 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1524 aa)
SLC6A1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (599 aa)
SLC6A11Sodium- and chloride-dependent GABA transporter 3. (574 aa)
STEAP4Metalloreductase STEAP4 isoform X1. (584 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (247 aa)
SLC7A1High affinity cationic amino acid transporter 1. (629 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2235 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (237 aa)
SLC12A6Solute carrier family 12 member 6 isoform X1. (1150 aa)
SLC39A5Zinc transporter ZIP5. (358 aa)
SLC12A2Solute carrier family 12 member 2. (1105 aa)
KCNJ13Potassium voltage-gated channel subfamily J member 13. (360 aa)
SLC7A11Cystine/glutamate transporter isoform X2. (486 aa)
LRRC8EVolume-regulated anion channel subunit LRRC8E. (739 aa)
SLC27A2Very long-chain acyl-CoA synthetase. (623 aa)
CACNA1GLOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G. (548 aa)
KCNJ4LOW QUALITY PROTEIN: inward rectifier potassium channel 4. (324 aa)
SLC3A24F2 cell-surface antigen heavy chain. (545 aa)
SLC5A2LOW QUALITY PROTEIN: sodium/glucose cotransporter 2; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (656 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (515 aa)
SLC7A8LOW QUALITY PROTEIN: large neutral amino acids transporter small subunit 2. (533 aa)
SLC6A13Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (374 aa)
ENSUMAP00000019341annotation not available (184 aa)
CD36Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family. (472 aa)
ATP12APotassium-transporting ATPase alpha chain 2; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (973 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (296 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (403 aa)
ENSUMAP00000018664annotation not available (401 aa)
ACSL1long-chain-fatty-acid--CoA ligase 1. (720 aa)
STEAP3Metalloreductase STEAP3. (336 aa)
SLC39A12Solute carrier family 39 member 12. (690 aa)
SLC8A1Sodium/calcium exchanger 1 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (622 aa)
SLC9A9Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (662 aa)
TSPO2Translocator protein 2. (173 aa)
TREML1Triggering receptor expressed on myeloid cells like 1. (313 aa)
TREM2Triggering receptor expressed on myeloid cells 2 isoform X2. (322 aa)
SLC46A1Solute carrier family 46 member 1. (451 aa)
TRPV6Transient receptor potential cation channel subfamily V member 6; Belongs to the transient receptor (TC 1.A.4) family. (752 aa)
STEAP2STEAP2 metalloreductase. (490 aa)
SLC12A4Solute carrier family 12 member 4. (1087 aa)
SLC39A4Zinc transporter ZIP4. (362 aa)
SLC9A5Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (821 aa)
ATP4ASodium/potassium-transporting ATPase subunit alpha. (1081 aa)
KCNE2Potassium voltage-gated channel subfamily E regulatory subunit 2. (138 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2127 aa)
ENSUMAP00000027960annotation not available (155 aa)
SLC39A10Solute carrier family 39 member 10. (833 aa)
LRRC8AVolume-regulated anion channel subunit LRRC8A. (835 aa)
ATP4BSodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (296 aa)
SLC9A2Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (793 aa)
SLC9A4Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (783 aa)
HFEHereditary hemochromatosis protein; Belongs to the MHC class I family. (332 aa)
SLC1A4Neutral amino acid transporter A. (427 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (617 aa)
SLC12A7Solute carrier family 12 member 7. (1168 aa)
SLC5A6Sodium-dependent multivitamin transporter isoform X4; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (638 aa)
SLC27A4Long-chain fatty acid transport protein 4. (705 aa)
SLC9A3Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (897 aa)
SLC1A7Amino acid transporter. (603 aa)
FAM155ATransmembrane protein FAM155A. (196 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
SLC1A5Amino acid transporter. (323 aa)
SLC8A2Sodium/calcium exchanger 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (197 aa)
SLC9A6Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (671 aa)
SLC8A3LOW QUALITY PROTEIN: sodium/calcium exchanger 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (893 aa)
SCNN1GLOW QUALITY PROTEIN: amiloride-sensitive sodium channel subunit gamma; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (599 aa)
SLC18A1Chromaffin granule amine transporter isoform X1. (524 aa)
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1975 aa)
SLC11A2Natural resistance-associated macrophage protein 2 isoform X1. (633 aa)
TRPV3Transient receptor potential cation channel subfamily V member 3 isoform X3; Belongs to the transient receptor (TC 1.A.4) family. (797 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (851 aa)
SLC7A5Large neutral amino acids transporter small subunit 1. (238 aa)
FOLR1Folate receptor alpha. (254 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (428 aa)
KCNJ16Inward rectifier potassium channel 16. (428 aa)
SCNN1AAmiloride-sensitive sodium channel subunit alpha; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (634 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1819 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (797 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (410 aa)
KCNJ3G protein-activated inward rectifier potassium channel 1 isoform X1. (497 aa)
ADGRV1LOW QUALITY PROTEIN: G-protein coupled receptor 98; Belongs to the G-protein coupled receptor 2 family. (6279 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2011 aa)
SLC29A1Solute carrier family 29 member 1 (Augustine blood group). (604 aa)
STRA6LOW QUALITY PROTEIN: stimulated by retinoic acid gene 6 protein homolog. (630 aa)
SLC39A8Zinc transporter ZIP8. (438 aa)
SLC24A4LOW QUALITY PROTEIN: sodium/potassium/calcium exchanger 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (606 aa)
SLC39A14Solute carrier family 39 member 14. (490 aa)
KCNJ12LOW QUALITY PROTEIN: ATP-sensitive inward rectifier potassium channel 12. (440 aa)
SCN11ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1747 aa)
SLC6A20Sodium- and chloride-dependent transporter XTRP3. (543 aa)
SLC9C1Sodium/hydrogen exchanger 10. (1157 aa)
SLC27A5Bile acyl-CoA synthetase isoform X1. (687 aa)
SLC1A6Amino acid transporter. (528 aa)
SLC36A1Proton-coupled amino acid transporter 1 isoform X1. (507 aa)
GRM1Metabotropic glutamate receptor 1 isoform X1. (1173 aa)
SLC18A2Synaptic vesicular amine transporter. (497 aa)
KCNJ5G protein-activated inward rectifier potassium channel 4. (419 aa)
KCNJ1ATP-sensitive inward rectifier potassium channel 1. (405 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha-3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (498 aa)
TRPV4LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (837 aa)
IL10RAInterleukin-10 receptor subunit alpha. (575 aa)
SLC39A6Solute carrier family 39 member 6. (735 aa)
SLC6A2Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (629 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1823 aa)
LRSAM1E3 ubiquitin-protein ligase LRSAM1. (685 aa)
KCNJ8Potassium voltage-gated channel subfamily J member 8. (424 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1006 aa)
SPXSpexin. (110 aa)
LRRC8CVolume-regulated anion channel subunit LRRC8C isoform X1. (803 aa)
KCNJ10ATP-sensitive inward rectifier potassium channel 10. (194 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1041 aa)
SLC12A3LOW QUALITY PROTEIN: solute carrier family 12 member 3. (988 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1050 aa)
KCNJ15Potassium voltage-gated channel subfamily J member 15. (375 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (450 aa)
SLC15A4LOW QUALITY PROTEIN: solute carrier family 15 member 4. (407 aa)
SLC7A3Cationic amino acid transporter 3. (617 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (813 aa)
TRPV5Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (732 aa)
SLC22A1LOW QUALITY PROTEIN: solute carrier family 22 member 1. (549 aa)
SLC22A2LOW QUALITY PROTEIN: solute carrier family 22 member 2. (514 aa)
SLC22A3Solute carrier family 22 member 3 isoform X2. (404 aa)
SLC27A1Long-chain fatty acid transport protein 1. (668 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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