55 items (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	APP	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (747 aa)
	EIF2AK2	Interferon-induced, double-stranded RNA-activated protein kinase. (542 aa)
	TERF2IP	Telomeric repeat-binding factor 2-interacting protein 1. (346 aa)
	ENSUMAP00000018377	annotation not available (92 aa)
	SPHK1	LOW QUALITY PROTEIN: sphingosine kinase 1. (387 aa)
	CD14	Monocyte differentiation antigen CD14 isoform X2. (439 aa)
	TLR3	Toll-like receptor 3 isoform X1; Belongs to the Toll-like receptor family. (905 aa)
	TREML1	Triggering receptor expressed on myeloid cells like 1. (313 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2 isoform X2. (322 aa)
	ENSUMAP00000015424	annotation not available (80 aa)
	ENSUMAP00000015418	annotation not available (242 aa)
	NLRP12	NACHT, LRR and PYD domains-containing protein 12. (552 aa)
	TRIP6	Thyroid receptor-interacting protein 6. (478 aa)
	TNFSF14	Tumor necrosis factor ligand superfamily member 14; Belongs to the tumor necrosis factor family. (245 aa)
	RPS3	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (245 aa)
	RELA	Transcription factor p65. (585 aa)
	ENSUMAP00000014414	annotation not available (310 aa)
	DDX3Y	LOW QUALITY PROTEIN: ATP-dependent RNA helicase DDX3X-like; Belongs to the DEAD box helicase family. (704 aa)
	AGER	Advanced glycosylation end product-specific receptor. (311 aa)
	EGFR	Receptor protein-tyrosine kinase. (1191 aa)
	MMP8	Matrix metallopeptidase 8. (475 aa)
	RTKN2	Rhotekin-2. (294 aa)
	CCL19	C-C motif chemokine. (115 aa)
	NOD2	Nucleotide-binding oligomerization domain-containing protein 2. (817 aa)
	LRRC19	Leucine-rich repeat-containing protein 19. (369 aa)
	TLR8	Toll-like receptor 8; Belongs to the Toll-like receptor family. (1039 aa)
	TLR7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1050 aa)
	TLR4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
	C20orf27	Chromosome 20 open reading frame 27. (174 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1189 aa)
	PHB2	Prohibitin. (297 aa)
	SASH1	SAM and SH3 domain-containing protein 1 isoform X1. (1239 aa)
	HAVCR2	Hepatitis A virus cellular receptor 2 isoform X1. (280 aa)
	NOD1	Nucleotide-binding oligomerization domain-containing protein 1. (263 aa)
	CCDC142	Coiled-coil domain-containing protein 142. (584 aa)
	EDA	ectodysplasin-A; Belongs to the tumor necrosis factor family. (242 aa)
	RBCK1	ranBP-type and C3HC4-type zinc finger-containing protein 1. (521 aa)
	ILK	Integrin-linked protein kinase. (452 aa)
	NMI	N-myc-interactor isoform X1. (336 aa)
	PTP4A3	Protein tyrosine phosphatase type IVA 3. (168 aa)
	IL18R1	Interleukin-18 receptor 1. (452 aa)
	EDAR	Tumor necrosis factor receptor superfamily member EDAR isoform X2. (447 aa)
	EP300	LOW QUALITY PROTEIN: histone acetyltransferase p300. (2390 aa)
	PDCD4	Programmed cell death protein 4. (469 aa)
	IFI35	LOW QUALITY PROTEIN: interferon-induced 35 kDa protein. (260 aa)
	TCIM	Transcriptional and immune response regulator. (106 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1133 aa)
	ACTN4	Alpha-actinin-4. (853 aa)
	TRADD	Tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2. (314 aa)
	TRIM44	Tripartite motif-containing protein 44. (516 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	DDX3X	DEAD-box helicase 3 X-linked. (608 aa)
	GREM1	Gremlin. (232 aa)
	PHB	Prohibitin. (265 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGER	APP	ENSUMAP00000013742	ENSUMAP00000020202	Advanced glycosylation end product-specific receptor.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.620
AGER	TNF	ENSUMAP00000013742	ENSUMAP00000020603	Advanced glycosylation end product-specific receptor.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.476
APP	AGER	ENSUMAP00000020202	ENSUMAP00000013742	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Advanced glycosylation end product-specific receptor.	0.620
APP	EGFR	ENSUMAP00000020202	ENSUMAP00000012230	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Receptor protein-tyrosine kinase.	0.425
APP	EP300	ENSUMAP00000020202	ENSUMAP00000029965	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	LOW QUALITY PROTEIN: histone acetyltransferase p300.	0.420
APP	TLR4	ENSUMAP00000020202	ENSUMAP00000005351	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.527
APP	TNF	ENSUMAP00000020202	ENSUMAP00000020603	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.552
APP	TREM2	ENSUMAP00000020202	ENSUMAP00000016626	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Triggering receptor expressed on myeloid cells 2 isoform X2.	0.491
APP	TREML1	ENSUMAP00000020202	ENSUMAP00000016637	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Triggering receptor expressed on myeloid cells like 1.	0.491
CCL19	TNF	ENSUMAP00000008297	ENSUMAP00000020603	C-C motif chemokine.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.509
CD14	TLR3	ENSUMAP00000018032	ENSUMAP00000016768	Monocyte differentiation antigen CD14 isoform X2.	Toll-like receptor 3 isoform X1; Belongs to the Toll-like receptor family.	0.452
CD14	TLR4	ENSUMAP00000018032	ENSUMAP00000005351	Monocyte differentiation antigen CD14 isoform X2.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.985
CD14	TLR7	ENSUMAP00000018032	ENSUMAP00000006805	Monocyte differentiation antigen CD14 isoform X2.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.442
CD14	TLR8	ENSUMAP00000018032	ENSUMAP00000006806	Monocyte differentiation antigen CD14 isoform X2.	Toll-like receptor 8; Belongs to the Toll-like receptor family.	0.442
CD14	TRAF6	ENSUMAP00000018032	ENSUMAP00000023966	Monocyte differentiation antigen CD14 isoform X2.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.421
DDX3X	RPS3	ENSUMAP00000023158	ENSUMAP00000014686	DEAD-box helicase 3 X-linked.	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	0.554
EDA	EDAR	ENSUMAP00000001226	ENSUMAP00000028765	ectodysplasin-A; Belongs to the tumor necrosis factor family.	Tumor necrosis factor receptor superfamily member EDAR isoform X2.	0.959
EDAR	EDA	ENSUMAP00000028765	ENSUMAP00000001226	Tumor necrosis factor receptor superfamily member EDAR isoform X2.	ectodysplasin-A; Belongs to the tumor necrosis factor family.	0.959
EGFR	APP	ENSUMAP00000012230	ENSUMAP00000020202	Receptor protein-tyrosine kinase.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.425
EGFR	RELA	ENSUMAP00000012230	ENSUMAP00000014520	Receptor protein-tyrosine kinase.	Transcription factor p65.	0.666