(26 nodes) Regulation of sprouting angiogenesis network (Ursus maritimus)

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Predicted Interactions

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Your Input:
	SYNJ2BP	Synaptojanin-2-binding protein. (145 aa)
	IL10	Interleukin-10. (178 aa)
	PDPK1	3-phosphoinositide-dependent protein kinase 1 isoform X1. (572 aa)
	S100A1	S100 calcium binding protein A1. (94 aa)
	SEMA6A	LOW QUALITY PROTEIN: semaphorin-6A; Belongs to the semaphorin family. (1028 aa)
	GLUL	Glutamine synthetase. (373 aa)
	ALOX5	Arachidonate 5-lipoxygenase. (637 aa)
	JCAD	Junctional protein associated with coronary artery disease. (1375 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	CREB3L1	LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 1. (501 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
	THBS1	LOW QUALITY PROTEIN: thrombospondin-1. (1168 aa)
	RHOJ	Rho-related GTP-binding protein RhoJ isoform X1. (236 aa)
	E2F2	Transcription factor E2F2. (443 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	ITGA5	Integrin alpha-5; Belongs to the integrin alpha chain family. (1015 aa)
	EPN1	Epsin-1. (545 aa)
	PKM	Pyruvate kinase; Belongs to the pyruvate kinase family. (522 aa)
	ENSUMAP00000011788	annotation not available (109 aa)
	PARP6	Poly [ADP-ribose] polymerase. (459 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (695 aa)
	JAK1	Tyrosine-protein kinase. (1153 aa)
	EPN2	Epsin-2 isoform X4. (583 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
	BMPER	BMP-binding endothelial regulator protein. (650 aa)
	FUT1	L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (361 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSUMAP00000011788	PARP6	ENSUMAP00000011788	ENSUMAP00000011778	annotation not available	Poly [ADP-ribose] polymerase.	0.900
FGF1	FGF2	ENSUMAP00000015805	ENSUMAP00000005828	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.651
FGF1	PIK3CB	ENSUMAP00000015805	ENSUMAP00000020299	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.423
FGF2	FGF1	ENSUMAP00000005828	ENSUMAP00000015805	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.651
FGF2	IL10	ENSUMAP00000005828	ENSUMAP00000035264	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Interleukin-10.	0.551
FGF2	THBS1	ENSUMAP00000005828	ENSUMAP00000019620	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	LOW QUALITY PROTEIN: thrombospondin-1.	0.673
IL10	FGF2	ENSUMAP00000035264	ENSUMAP00000005828	Interleukin-10.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.551
IL10	JAK1	ENSUMAP00000035264	ENSUMAP00000011282	Interleukin-10.	Tyrosine-protein kinase.	0.678
ITGA5	THBS1	ENSUMAP00000015172	ENSUMAP00000019620	Integrin alpha-5; Belongs to the integrin alpha chain family.	LOW QUALITY PROTEIN: thrombospondin-1.	0.505
JAK1	IL10	ENSUMAP00000011282	ENSUMAP00000035264	Tyrosine-protein kinase.	Interleukin-10.	0.678
JAK1	PIK3CB	ENSUMAP00000011282	ENSUMAP00000020299	Tyrosine-protein kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.942
PARP6	ENSUMAP00000011788	ENSUMAP00000011778	ENSUMAP00000011788	Poly [ADP-ribose] polymerase.	annotation not available	0.900
PDPK1	PIK3CB	ENSUMAP00000031700	ENSUMAP00000020299	3-phosphoinositide-dependent protein kinase 1 isoform X1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.960
PIK3CB	FGF1	ENSUMAP00000020299	ENSUMAP00000015805	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.423
PIK3CB	JAK1	ENSUMAP00000020299	ENSUMAP00000011282	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Tyrosine-protein kinase.	0.942
PIK3CB	PDPK1	ENSUMAP00000020299	ENSUMAP00000031700	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	3-phosphoinositide-dependent protein kinase 1 isoform X1.	0.960
THBS1	FGF2	ENSUMAP00000019620	ENSUMAP00000005828	LOW QUALITY PROTEIN: thrombospondin-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.673
THBS1	ITGA5	ENSUMAP00000019620	ENSUMAP00000015172	LOW QUALITY PROTEIN: thrombospondin-1.	Integrin alpha-5; Belongs to the integrin alpha chain family.	0.505