STRINGSTRING
EXOSC10 EXOSC10 TINF2 TINF2 BMPR2 BMPR2 PINX1 PINX1 PARP3 PARP3 ACD ACD GNL3L GNL3L TERF1 TERF1 TERF2 TERF2 NAT10 NAT10 CTC1 CTC1 DCP2 DCP2 TP53 TP53 GDF2 GDF2 HNRNPU HNRNPU PIF1 PIF1 TEN1 TEN1 DACH1 DACH1 ACVRL1 ACVRL1 POT1 POT1 ADIPOQ ADIPOQ SRC SRC NIBAN2 NIBAN2 ANKRD1 ANKRD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EXOSC10LOW QUALITY PROTEIN: exosome component 10. (875 aa)
TINF2LOW QUALITY PROTEIN: TERF1-interacting nuclear factor 2. (394 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
PINX1PIN2/TERF1-interacting telomerase inhibitor 1 isoform X1. (316 aa)
PARP3Poly [ADP-ribose] polymerase. (529 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (452 aa)
GNL3LGuanine nucleotide-binding protein-like 3-like protein isoform X1. (603 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (261 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (483 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1026 aa)
CTC1LOW QUALITY PROTEIN: CST complex subunit CTC1. (1247 aa)
DCP2m7GpppN-mRNA hydrolase isoform X2. (422 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
GDF2Growth/differentiation factor 2. (402 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (767 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (579 aa)
TEN1CST complex subunit TEN1 isoform X1. (158 aa)
DACH1LOW QUALITY PROTEIN: dachshund homolog 1. (583 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
POT1Protection of telomeres protein 1. (597 aa)
ADIPOQAdiponectin isoform X2. (297 aa)
SRCTyrosine-protein kinase. (618 aa)
NIBAN2Niban-like protein 1. (606 aa)
ANKRD1Ankyrin repeat domain-containing protein 1. (319 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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