STRINGSTRING
ALOX5 ALOX5 ARG2 ARG2 PARK2 PARK2 ENSUMAP00000015922 ENSUMAP00000015922 PARK2-2 PARK2-2 HIF1A HIF1A THBS1 THBS1 F2 F2 PDGFB PDGFB SPHK2 SPHK2 ZNF205 ZNF205 ZC3H12A ZC3H12A LOC103677394 LOC103677394 EIF6 EIF6 LOC103662452 LOC103662452 MMP12 MMP12 GRB2 GRB2 LOC103673846 LOC103673846 PLIN5 PLIN5 COQ7 COQ7 BCO2 BCO2 GADD45A GADD45A ENSUMAP00000008652 ENSUMAP00000008652 PARL PARL LOC103663090 LOC103663090 INS-IGF2 INS-IGF2 HK2 HK2 F2RL1 F2RL1 ROMO1 ROMO1 TLR4 TLR4 DHFR DHFR CRP CRP MT3 MT3 BCR BCR MMP8 MMP8 BECN1 BECN1 COA8 COA8 LOC103680048 LOC103680048 ABCD2 ABCD2 PARK7 PARK7 PRCP PRCP RAB27A RAB27A PIKFYVE PIKFYVE RIPK3 RIPK3 AATF AATF TUSC2 TUSC2 PON2 PON2 PON3 PON3 SLC30A10 SLC30A10 CLCN3 CLCN3 TSPO TSPO ENSUMAP00000027960 ENSUMAP00000027960 PRKCD PRKCD SLC5A3 SLC5A3 ATG5 ATG5 FOXO3 FOXO3 SIRT2 SIRT2 PINK1 PINK1 RIPK1 RIPK1 DUOXA1 DUOXA1 DUOXA2 DUOXA2 TFAP2A TFAP2A VDAC1 VDAC1 PID1 PID1 TP53 TP53 RNF41 RNF41 SYK SYK FOXM1 FOXM1 LOC103671894 LOC103671894 TIGAR TIGAR TNF TNF UCP1 UCP1 PLCG2 PLCG2 NFE2L2 NFE2L2 CLEC7A CLEC7A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ALOX5Arachidonate 5-lipoxygenase. (637 aa)
ARG2Arginase. (354 aa)
PARK2E3 ubiquitin-protein ligase parkin isoform X5. (153 aa)
ENSUMAP00000015922annotation not available (110 aa)
PARK2-2E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (176 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X2. (823 aa)
THBS1LOW QUALITY PROTEIN: thrombospondin-1. (1168 aa)
F2Prothrombin; Belongs to the peptidase S1 family. (569 aa)
PDGFBPlatelet-derived growth factor subunit B. (234 aa)
SPHK2Sphingosine kinase 2. (417 aa)
ZNF205Zinc finger protein 205. (565 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (582 aa)
LOC103677394Transforming growth factor beta-1. (299 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
LOC103662452Stromelysin-1. (459 aa)
MMP12Matrix metallopeptidase 12. (493 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
LOC103673846Cytochrome b-245 light chain. (218 aa)
PLIN5Perilipin; Belongs to the perilipin family. (447 aa)
COQ75-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (266 aa)
BCO2Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1. (602 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (103 aa)
ENSUMAP00000008652annotation not available (187 aa)
PARLPresenilins-associated rhomboid-like protein, mitochondrial. (381 aa)
LOC103663090Reactive oxygen species modulator 1-like. (79 aa)
INS-IGF2Insulin, isoform 2-like; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (199 aa)
HK2LOW QUALITY PROTEIN: hexokinase-2. (904 aa)
F2RL1Proteinase-activated receptor 2. (399 aa)
ROMO1Reactive oxygen species modulator 1. (79 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
DHFRDihydrofolate reductase; Belongs to the dihydrofolate reductase family. (187 aa)
CRPC-reactive protein. (99 aa)
MT3Metallothionein 3. (68 aa)
BCRBCR activator of RhoGEF and GTPase. (1162 aa)
MMP8Matrix metallopeptidase 8. (475 aa)
BECN1Beclin-1 isoform X1. (555 aa)
COA8Cytochrome c oxidase assembly factor 8. (234 aa)
LOC103680048Tripartite motif-containing protein 5-like isoform X2. (306 aa)
ABCD2ATP-binding cassette sub-family D member 2. (742 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
PRCPLysosomal Pro-X carboxypeptidase. (495 aa)
RAB27ARAB27A, member RAS oncogene family. (221 aa)
PIKFYVELOW QUALITY PROTEIN: 1-phosphatidylinositol 3-phosphate 5-kinase. (2090 aa)
RIPK3Receptor-interacting serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. (487 aa)
AATFProtein AATF. (523 aa)
TUSC2Tumor suppressor candidate 2. (107 aa)
PON2Serum paraoxonase/arylesterase 2. (358 aa)
PON3Serum paraoxonase/lactonase 3 isoform X1. (374 aa)
SLC30A10Zinc transporter 10. (458 aa)
CLCN3Chloride channel protein. (866 aa)
TSPOTranslocator protein. (194 aa)
ENSUMAP00000027960annotation not available (155 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (725 aa)
SLC5A3Sodium/myo-inositol cotransporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (718 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
FOXO3Forkhead box protein O3. (453 aa)
SIRT2NAD-dependent protein deacetylase sirtuin-2 isoform X1. (471 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial. (533 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
DUOXA1Dual oxidase maturation factor 1. (342 aa)
DUOXA2Dual oxidase maturation factor 2 isoform X2. (335 aa)
TFAP2ALOW QUALITY PROTEIN: transcription factor AP-2-alpha. (494 aa)
VDAC1Voltage-dependent anion-selective channel protein 1. (283 aa)
PID1PTB-containing, cubilin and LRP1-interacting protein isoform X2. (220 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
RNF41E3 ubiquitin-protein ligase NRDP1. (317 aa)
SYKTyrosine-protein kinase SYK; Belongs to the protein kinase superfamily. Tyr protein kinase family. (610 aa)
FOXM1Forkhead box protein M1. (763 aa)
LOC103671894Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (172 aa)
TIGARFructose-2,6-bisphosphatase TIGAR. (211 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
UCP1Mitochondrial brown fat uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (308 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1191 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform X2. (590 aa)
CLEC7AC-type lectin domain family 7 member A isoform X2. (202 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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