(46 nodes) Positive regulation of DNA biosynthetic process network (Ursus maritimus)

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second shell of interactors

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proteins of unknown 3D structure

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experimentally determined

Predicted Interactions

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Your Input:
	ENSUMAP00000019418	annotation not available (129 aa)
	MAP3K4	Mitogen-activated protein kinase kinase kinase 4. (1511 aa)
	MAPK3	Mitogen-activated protein kinase. (354 aa)
	SMOC2	SPARC-related modular calcium-binding protein 2. (423 aa)
	TNKS	Poly [ADP-ribose] polymerase. (1333 aa)
	MAPKAPK5	MAP kinase-activated protein kinase 5 isoform X2. (471 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3061 aa)
	GINS2	DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (175 aa)
	CCT7	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (543 aa)
	MAPK1	Mitogen-activated protein kinase. (363 aa)
	FBXO4	F-box only protein 4. (374 aa)
	RFC4	Replication factor C subunit 4. (363 aa)
	PARN	poly(A)-specific ribonuclease PARN. (638 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (301 aa)
	POT1	Protection of telomeres protein 1. (597 aa)
	PARM1	Prostate androgen-regulated mucin-like protein 1. (309 aa)
	PNKP	Bifunctional polynucleotide phosphatase/kinase. (472 aa)
	PDGFB	Platelet-derived growth factor subunit B. (234 aa)
	TCP1	T-complex protein 1 subunit alpha. (556 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
	RFC2	Replication factor C subunit 2. (325 aa)
	GINS4	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
	NEK7	Serine/threonine-protein kinase Nek7 isoform X1; Belongs to the protein kinase superfamily. (302 aa)
	FGFR4	Fibroblast growth factor receptor. (795 aa)
	NOX4	NADPH oxidase 4. (578 aa)
	PRKD2	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (833 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	HMBOX1	Homeobox-containing protein 1 isoform X2. (407 aa)
	GINS3	DNA replication complex GINS protein PSF3. (216 aa)
	DSCC1	DNA replication and sister chromatid cohesion 1. (392 aa)
	CHTF18	Chromosome transmission fidelity protein 18 homolog. (359 aa)
	NEK2	Serine/threonine-protein kinase Nek2. (424 aa)
	CCT4	T-complex protein 1 subunit delta. (561 aa)
	CCT2	Chaperonin containing TCP1 subunit 2. (535 aa)
	XRCC5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (731 aa)
	ACD	ACD shelterin complex subunit and telomerase recruitment factor. (452 aa)
	DERPC	DERPC proline and glycine rich nuclear protein. (540 aa)
	CHTF8	Chromosome transmission fidelity protein 8 homolog. (114 aa)
	CCT3	T-complex protein 1 subunit gamma. (545 aa)
	POLG2	DNA polymerase subunit gamma-2, mitochondrial isoform X1. (485 aa)
	DKC1	H/ACA ribonucleoprotein complex subunit 4. (537 aa)
	WRAP53	Telomerase Cajal body protein 1. (190 aa)
	NVL	Nuclear valosin-containing protein-like isoform X1. (871 aa)
	GREM1	Gremlin. (232 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACD	DKC1	ENSUMAP00000026983	ENSUMAP00000023513	ACD shelterin complex subunit and telomerase recruitment factor.	H/ACA ribonucleoprotein complex subunit 4.	0.701
ACD	POT1	ENSUMAP00000026983	ENSUMAP00000007560	ACD shelterin complex subunit and telomerase recruitment factor.	Protection of telomeres protein 1.	0.998
ACD	WRAP53	ENSUMAP00000026983	ENSUMAP00000023212	ACD shelterin complex subunit and telomerase recruitment factor.	Telomerase Cajal body protein 1.	0.458
ATM	ENSUMAP00000019418	ENSUMAP00000011132	ENSUMAP00000019418	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	annotation not available	0.654
ATM	PCNA	ENSUMAP00000011132	ENSUMAP00000005923	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.542
ATM	RFC2	ENSUMAP00000011132	ENSUMAP00000019415	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Replication factor C subunit 2.	0.654
ATM	RFC3	ENSUMAP00000011132	ENSUMAP00000032889	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Replication factor C subunit 3.	0.728
ATM	RFC4	ENSUMAP00000011132	ENSUMAP00000005324	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Replication factor C subunit 4.	0.744
ATM	XRCC5	ENSUMAP00000011132	ENSUMAP00000027789	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.904
CCT2	CCT3	ENSUMAP00000028656	ENSUMAP00000024719	Chaperonin containing TCP1 subunit 2.	T-complex protein 1 subunit gamma.	0.999
CCT2	CCT4	ENSUMAP00000028656	ENSUMAP00000028802	Chaperonin containing TCP1 subunit 2.	T-complex protein 1 subunit delta.	0.999
CCT2	CCT7	ENSUMAP00000028656	ENSUMAP00000000070	Chaperonin containing TCP1 subunit 2.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.999
CCT2	TCP1	ENSUMAP00000028656	ENSUMAP00000016221	Chaperonin containing TCP1 subunit 2.	T-complex protein 1 subunit alpha.	0.999
CCT3	CCT2	ENSUMAP00000024719	ENSUMAP00000028656	T-complex protein 1 subunit gamma.	Chaperonin containing TCP1 subunit 2.	0.999
CCT3	CCT4	ENSUMAP00000024719	ENSUMAP00000028802	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit delta.	0.999
CCT3	CCT7	ENSUMAP00000024719	ENSUMAP00000000070	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.999
CCT3	TCP1	ENSUMAP00000024719	ENSUMAP00000016221	T-complex protein 1 subunit gamma.	T-complex protein 1 subunit alpha.	0.999
CCT4	CCT2	ENSUMAP00000028802	ENSUMAP00000028656	T-complex protein 1 subunit delta.	Chaperonin containing TCP1 subunit 2.	0.999
CCT4	CCT3	ENSUMAP00000028802	ENSUMAP00000024719	T-complex protein 1 subunit delta.	T-complex protein 1 subunit gamma.	0.999
CCT4	CCT7	ENSUMAP00000028802	ENSUMAP00000000070	T-complex protein 1 subunit delta.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.999