94 items (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F3	Tissue factor. (295 aa)
	LAPTM5	Lysosomal-associated transmembrane protein 5. (292 aa)
	UACA	Uveal autoantigen with Coiled-coil domains and Ankyrin repeats. (1373 aa)
	RACK1	Guanine nucleotide-binding protein subunit beta-2-like 1. (374 aa)
	MTCH1	LOW QUALITY PROTEIN: mitochondrial carrier homolog 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (280 aa)
	DDX3Y	LOW QUALITY PROTEIN: ATP-dependent RNA helicase DDX3X-like; Belongs to the DEAD box helicase family. (704 aa)
	EGLN3	Egl-9 family hypoxia inducible factor 3. (239 aa)
	BOK	Bcl-2-related ovarian killer protein. (300 aa)
	RPS3	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (245 aa)
	CTSH	LOW QUALITY PROTEIN: pro-cathepsin H; Belongs to the peptidase C1 family. (295 aa)
	CASP8AP2	Caspase 8 associated protein 2. (1994 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
	LOC103668179	LOW QUALITY PROTEIN: high mobility group protein B1-like. (200 aa)
	BCL2L11	Bcl-2-like protein 11 isoform X11. (84 aa)
	AIFM1	Apoptosis inducing factor mitochondria associated 1. (612 aa)
	TFAP4	Transcription factor AP-4. (336 aa)
	BAD	Bcl2-associated agonist of cell death. (168 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (250 aa)
	PPM1F	Protein phosphatase 1F. (278 aa)
	GSN	Gelsolin isoform X1. (748 aa)
	PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1. (53 aa)
	LGMN	Legumain. (433 aa)
	CLEC7A	C-type lectin domain family 7 member A isoform X2. (202 aa)
	SYK	Tyrosine-protein kinase SYK; Belongs to the protein kinase superfamily. Tyr protein kinase family. (610 aa)
	RIPK2	LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 2. (512 aa)
	CASP2	Caspase-2 isoform X1; Belongs to the peptidase C14A family. (452 aa)
	SMAD3	Mothers against decapentaplegic homolog. (280 aa)
	LOC103665481	Putative Bcl-2 homologous antagonist/killer 2. (349 aa)
	ANP32B	Acidic leucine-rich nuclear phosphoprotein 32 family member B. (272 aa)
	FAS	Tumor necrosis factor receptor superfamily member 6 isoform X1. (351 aa)
	ENSUMAP00000017050	annotation not available (80 aa)
	NLRP1	NACHT, LRR and PYD domains-containing protein 1. (1436 aa)
	HIP1R	Huntingtin-interacting protein 1-related protein. (915 aa)
	HIP1	Huntingtin-interacting protein 1. (1000 aa)
	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1. (771 aa)
	NLRP6	NACHT, LRR and PYD domains-containing protein 6. (795 aa)
	PML	Promyelocytic leukemia. (880 aa)
	IFT57	Intraflagellar transport protein 57 homolog. (390 aa)
	DIABLO	Diablo homolog, mitochondrial. (270 aa)
	ACVR1C	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (488 aa)
	PIDD1	LOW QUALITY PROTEIN: p53-induced death domain-containing protein 1. (844 aa)
	TTBK1	Tau-tubulin kinase 1. (756 aa)
	YJEFN3	yjeF N-terminal domain-containing protein 3. (142 aa)
	NDUFA13	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13. (161 aa)
	GPER1	G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	ENSUMAP00000008777	annotation not available (79 aa)
	TNFSF15	Tumor necrosis factor ligand superfamily member 15. (174 aa)
	FADD	FAS-associated death domain protein. (192 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1 isoform X2. (446 aa)
	ATP2A3	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (982 aa)
	P2RX1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
	NODAL	Nodal homolog. (271 aa)
	TNFSF10	Tumor necrosis factor ligand superfamily member 10; Belongs to the tumor necrosis factor family. (286 aa)
	DAPK1	Death-associated protein kinase 1 isoform X2. (1415 aa)
	ENSUMAP00000010849	annotation not available (93 aa)
	REST	RE1-silencing transcription factor. (1213 aa)
	PDCD2	Programmed cell death protein 2. (284 aa)
	ACER2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (288 aa)
	DDX3X	DEAD-box helicase 3 X-linked. (608 aa)
	ENSUMAP00000023183	annotation not available (141 aa)
	TBC1D10A	TBC1 domain family member 10A. (518 aa)
	HMGB1	High mobility group protein B1. (215 aa)
	MUL1	Mitochondrial ubiquitin ligase activator of NFKB 1. (252 aa)
	GRAMD4	GRAM domain-containing protein 4. (623 aa)
	NEK5	Serine/threonine-protein kinase Nek5. (753 aa)
	FASLG	Tumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (269 aa)
	DLC1-2	Rho GTPase-activating protein 7 isoform X5. (361 aa)
	S100A8	Protein S100; Belongs to the S-100 family. (136 aa)
	S100A9	Protein S100; Belongs to the S-100 family. (130 aa)
	CYFIP2	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1056 aa)
	BCAP31	B-cell receptor-associated protein 31. (246 aa)
	CFLAR	CASP8 and FADD-like apoptosis regulator isoform X2; Belongs to the peptidase C14A family. (482 aa)
	CASP10	Caspase-10 isoform X1; Belongs to the peptidase C14A family. (481 aa)
	CASP8	Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
	CASP9	Caspase-9 isoform X1; Belongs to the peptidase C14A family. (413 aa)
	DAP	Death-associated protein 1. (77 aa)
	PDCD6	Programmed cell death protein 6. (185 aa)
	CIDEB	Cell death inducing DFFA like effector b. (221 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1768 aa)
	FAM162A	Protein FAM162A. (155 aa)
	ENSUMAP00000018377	annotation not available (92 aa)
	PDCD5	Programmed cell death protein 5. (87 aa)
	ASPH	Aspartyl/asparaginyl beta-hydroxylase isoform X2. (756 aa)
	PYCARD	Apoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
	ENSUMAP00000020575	annotation not available (177 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	USP50	Inactive ubiquitin carboxyl-terminal hydrolase 50; Belongs to the peptidase C19 family. (366 aa)
	SENP1	Sentrin-specific protease 1 isoform X2. (637 aa)
	BAX	Apoptosis regulator BAX. (221 aa)
	CYCS	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	HTRA2	LOW QUALITY PROTEIN: serine protease HTRA2, mitochondrial. (455 aa)
	NOD1	Nucleotide-binding oligomerization domain-containing protein 1. (263 aa)
	CCN1	Cellular communication network factor 1. (382 aa)
	BCL10	BCL10 immune signaling adaptor. (234 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR1C	NODAL	ENSUMAP00000007257	ENSUMAP00000010583	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Nodal homolog.	0.943
ACVR1C	SMAD3	ENSUMAP00000007257	ENSUMAP00000016415	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.552
AIFM1	BAX	ENSUMAP00000016064	ENSUMAP00000001480	Apoptosis inducing factor mitochondria associated 1.	Apoptosis regulator BAX.	0.914
AIFM1	BCL2L11	ENSUMAP00000016064	ENSUMAP00000015720	Apoptosis inducing factor mitochondria associated 1.	Bcl-2-like protein 11 isoform X11.	0.445
AIFM1	CYCS	ENSUMAP00000016064	ENSUMAP00000001665	Apoptosis inducing factor mitochondria associated 1.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.401
BAD	BAX	ENSUMAP00000003173	ENSUMAP00000001480	Bcl2-associated agonist of cell death.	Apoptosis regulator BAX.	0.857
BAD	BCL2L11	ENSUMAP00000003173	ENSUMAP00000015720	Bcl2-associated agonist of cell death.	Bcl-2-like protein 11 isoform X11.	0.897
BAD	BID	ENSUMAP00000003173	ENSUMAP00000015536	Bcl2-associated agonist of cell death.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.731
BAD	BOK	ENSUMAP00000003173	ENSUMAP00000014244	Bcl2-associated agonist of cell death.	Bcl-2-related ovarian killer protein.	0.824
BAD	CASP2	ENSUMAP00000003173	ENSUMAP00000016144	Bcl2-associated agonist of cell death.	Caspase-2 isoform X1; Belongs to the peptidase C14A family.	0.558
BAD	CASP9	ENSUMAP00000003173	ENSUMAP00000030022	Bcl2-associated agonist of cell death.	Caspase-9 isoform X1; Belongs to the peptidase C14A family.	0.623
BAD	CFLAR	ENSUMAP00000003173	ENSUMAP00000029777	Bcl2-associated agonist of cell death.	CASP8 and FADD-like apoptosis regulator isoform X2; Belongs to the peptidase C14A family.	0.414
BAD	FADD	ENSUMAP00000003173	ENSUMAP00000009429	Bcl2-associated agonist of cell death.	FAS-associated death domain protein.	0.505
BAD	LOC103665481	ENSUMAP00000003173	ENSUMAP00000016562	Bcl2-associated agonist of cell death.	Putative Bcl-2 homologous antagonist/killer 2.	0.848
BAX	AIFM1	ENSUMAP00000001480	ENSUMAP00000016064	Apoptosis regulator BAX.	Apoptosis inducing factor mitochondria associated 1.	0.914
BAX	BAD	ENSUMAP00000001480	ENSUMAP00000003173	Apoptosis regulator BAX.	Bcl2-associated agonist of cell death.	0.857
BAX	BCL2L11	ENSUMAP00000001480	ENSUMAP00000015720	Apoptosis regulator BAX.	Bcl-2-like protein 11 isoform X11.	0.949
BAX	BID	ENSUMAP00000001480	ENSUMAP00000015536	Apoptosis regulator BAX.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.998
BAX	CASP9	ENSUMAP00000001480	ENSUMAP00000030022	Apoptosis regulator BAX.	Caspase-9 isoform X1; Belongs to the peptidase C14A family.	0.507
BAX	CYCS	ENSUMAP00000001480	ENSUMAP00000001665	Apoptosis regulator BAX.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.983