STRINGSTRING
STYXL1 STYXL1 INHBA INHBA RACK1 RACK1 BCL10 BCL10 DEDD2 DEDD2 BAD BAD DNM1L DNM1L CRADD CRADD PAK2 PAK2 DAB2IP DAB2IP TP63 TP63 BMPR1B BMPR1B PMAIP1 PMAIP1 SFPQ SFPQ FLCN FLCN AGT AGT PML PML CYLD CYLD GPER1 GPER1 ENSUMAP00000008777 ENSUMAP00000008777 FBXW9 FBXW9 PPP2R1B PPP2R1B PDIA3 PDIA3 NCK2 NCK2 S100A9 S100A9 S100A8 S100A8 ENSUMAP00000027960 ENSUMAP00000027960 DDIT3 DDIT3 LOC103658125 LOC103658125 LOC103658124 LOC103658124 LOC103658131 LOC103658131 TRIM61 TRIM61 RNF183 RNF183 TRIM39-RPP21 TRIM39-RPP21 RIPK1 RIPK1 ZSWIM2 ZSWIM2 EEF1E1 EEF1E1 ATF3 ATF3 SRPX SRPX TIMP3 TIMP3 STK3 STK3 TP53 TP53 PRKRA PRKRA FBXW7 FBXW7 TNF TNF NCK1 NCK1 BCAP31 BCAP31 G0S2 G0S2 TRAF7 TRAF7 RIPK3 RIPK3 NFATC4 NFATC4 TRAF2 TRAF2 IL20RA IL20RA BCLAF1 BCLAF1 PARK7 PARK7 MAPK9 MAPK9 BECN1 BECN1 IL19 IL19 PTPRC PTPRC STK4 STK4 SFRP1 SFRP1 FADD FADD SIRT1 SIRT1 LTBR LTBR PIAS4 PIAS4 PTPN2 PTPN2 TGFBR1 TGFBR1 ENSUMAP00000017147 ENSUMAP00000017147 ENSUMAP00000017050 ENSUMAP00000017050 RAD9A RAD9A FAS FAS NOX1 NOX1 PTEN PTEN FBH1 FBH1 CASP2 CASP2 BID BID ENSUMAP00000010835 ENSUMAP00000010835 TNFSF10 TNFSF10 CTSH CTSH NUPR1 NUPR1 RPS3 RPS3 SKIL SKIL BOK BOK ING5 ING5 SERINC3 SERINC3 PLAGL2 PLAGL2 CLU CLU PEA15 PEA15 TNFRSF12A TNFRSF12A RBCK1 RBCK1 TPD52L1 TPD52L1 BAX BAX GSDME GSDME ADORA2A ADORA2A HTRA2 HTRA2 CAV1 CAV1 WWOX WWOX NF1 NF1 THBS1 THBS1 PYCARD PYCARD INCA1 INCA1 ENSUMAP00000018377 ENSUMAP00000018377
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STYXL1Serine/threonine/tyrosine-interacting-like protein 1. (316 aa)
INHBAInhibin subunit beta A. (424 aa)
RACK1Guanine nucleotide-binding protein subunit beta-2-like 1. (374 aa)
BCL10BCL10 immune signaling adaptor. (234 aa)
DEDD2DNA-binding death effector domain-containing protein 2. (327 aa)
BADBcl2-associated agonist of cell death. (168 aa)
DNM1LDynamin-1-like protein isoform X7; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
CRADDCASP2 and RIPK1 domain containing adaptor with death domain. (250 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
DAB2IPDisabled homolog 2-interacting protein. (877 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (53 aa)
SFPQSplicing factor, proline- and glutamine-rich. (341 aa)
FLCNFolliculin. (579 aa)
AGTAngiotensinogen; Belongs to the serpin family. (475 aa)
PMLPromyelocytic leukemia. (880 aa)
CYLDLOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family. (948 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
ENSUMAP00000008777annotation not available (79 aa)
FBXW9F-box/WD repeat-containing protein 9. (367 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (650 aa)
PDIA3Protein disulfide-isomerase. (458 aa)
NCK2Cytoplasmic protein. (380 aa)
S100A9Protein S100; Belongs to the S-100 family. (130 aa)
S100A8Protein S100; Belongs to the S-100 family. (136 aa)
ENSUMAP00000027960annotation not available (155 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
LOC103658125Putative tripartite motif-containing protein 75. (309 aa)
LOC103658124Tripartite motif-containing protein 60-like. (200 aa)
LOC103658131Putative tripartite motif-containing protein 75. (105 aa)
TRIM61Tripartite motif-containing protein 60-like. (216 aa)
RNF183RING finger protein 183. (190 aa)
TRIM39-RPP21E3 ubiquitin-protein ligase TRIM39 isoform X2. (469 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
ZSWIM2E3 ubiquitin-protein ligase ZSWIM2. (633 aa)
EEF1E1Eukaryotic translation elongation factor 1 epsilon-1 isoform X1. (174 aa)
ATF3Cyclic AMP-dependent transcription factor ATF-3. (181 aa)
SRPXSushi repeat containing protein X-linked. (463 aa)
TIMP3TIMP metallopeptidase inhibitor 3. (211 aa)
STK3Serine/threonine-protein kinase 3. (497 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
PRKRAInterferon-inducible double-stranded RNA-dependent protein kinase activator A. (288 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (706 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
NCK1NCK adaptor protein 1. (244 aa)
BCAP31B-cell receptor-associated protein 31. (246 aa)
G0S2G0/G1 switch protein 2. (106 aa)
TRAF7E3 ubiquitin-protein ligase TRAF7. (102 aa)
RIPK3Receptor-interacting serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. (487 aa)
NFATC4LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4. (787 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (494 aa)
IL20RAInterleukin-20 receptor subunit alpha. (502 aa)
BCLAF1Bcl-2-associated transcription factor 1 isoform X1. (921 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
BECN1Beclin-1 isoform X1. (555 aa)
IL19Interleukin-19. (177 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1268 aa)
STK4Serine/threonine-protein kinase 4. (496 aa)
SFRP1Secreted frizzled-related protein 1. (305 aa)
FADDFAS-associated death domain protein. (192 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X2. (446 aa)
LTBRTumor necrosis factor receptor superfamily member 3 isoform X2. (421 aa)
PIAS4E3 SUMO-protein ligase PIAS4. (404 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (400 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
ENSUMAP00000017147annotation not available (109 aa)
ENSUMAP00000017050annotation not available (80 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (412 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X1. (351 aa)
NOX1NADPH oxidase 1 isoform X1. (568 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (565 aa)
FBH1F-box only protein 18. (972 aa)
CASP2Caspase-2 isoform X1; Belongs to the peptidase C14A family. (452 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
ENSUMAP00000010835annotation not available (213 aa)
TNFSF10Tumor necrosis factor ligand superfamily member 10; Belongs to the tumor necrosis factor family. (286 aa)
CTSHLOW QUALITY PROTEIN: pro-cathepsin H; Belongs to the peptidase C1 family. (295 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
RPS340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (245 aa)
SKILSki-like protein isoform X2. (664 aa)
BOKBcl-2-related ovarian killer protein. (300 aa)
ING5Inhibitor of growth protein. (256 aa)
SERINC3Serine incorporator 3. (473 aa)
PLAGL2Zinc finger protein PLAGL2. (496 aa)
CLUClusterin; Belongs to the clusterin family. (476 aa)
PEA15Astrocytic phosphoprotein PEA-15. (130 aa)
TNFRSF12ATumor necrosis factor receptor superfamily member 12A. (160 aa)
RBCK1ranBP-type and C3HC4-type zinc finger-containing protein 1. (521 aa)
TPD52L1Tumor protein D53 isoform X2. (191 aa)
BAXApoptosis regulator BAX. (221 aa)
GSDMENon-syndromic hearing impairment protein 5. (495 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (409 aa)
HTRA2LOW QUALITY PROTEIN: serine protease HTRA2, mitochondrial. (455 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
WWOXWW domain-containing oxidoreductase. (377 aa)
NF1Neurofibromin. (2862 aa)
THBS1LOW QUALITY PROTEIN: thrombospondin-1. (1168 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
INCA1LOW QUALITY PROTEIN: protein INCA1. (227 aa)
ENSUMAP00000018377annotation not available (92 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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