STRINGSTRING
SH3RF1 SH3RF1 STRADB STRADB RPS6KB1 RPS6KB1 ENSUMAP00000031695 ENSUMAP00000031695 ITPRIP ITPRIP TNFAIP3 TNFAIP3 PARK7 PARK7 EYA4 EYA4 PSME3 PSME3 EYA2 EYA2 UNC5B UNC5B GSK3B GSK3B IL19 IL19 FAIM2 FAIM2 GATA1 GATA1 PAK5 PAK5 CTTN CTTN CSF2 CSF2 MAPK7 MAPK7 FGF10 FGF10 RNF34 RNF34 GFRAL GFRAL SRC SRC PEA15 PEA15 ZMYND11 ZMYND11 HTT HTT RB1CC1 RB1CC1 YAP1 YAP1 ZC3HC1 ZC3HC1 GDNF GDNF GCLM GCLM DDX3Y DDX3Y RELA RELA EYA3 EYA3 PELI3 PELI3 IFI6 IFI6 SIAH2 SIAH2 TGFBR1 TGFBR1 HGF HGF SGK3 SGK3 FAIM FAIM IL7 IL7 TNF TNF ITGA6 ITGA6 BMP4 BMP4 LGALS3 LGALS3 SFRP2 SFRP2 PHIP PHIP RFFL RFFL DDX3X DDX3X HMOX1 HMOX1 AR AR RAF1 RAF1 SCG2 SCG2 LMNA LMNA ARHGEF2 ARHGEF2 ITGAV ITGAV RIPK1 RIPK1 EYA1 EYA1 ENSUMAP00000025747 ENSUMAP00000025747 LOC103658794 LOC103658794 BIRC6 BIRC6 TMBIM1 TMBIM1 ENSUMAP00000027960 ENSUMAP00000027960 CFLAR CFLAR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SH3RF1E3 ubiquitin-protein ligase SH3RF1. (869 aa)
STRADBSTE20-related kinase adapter protein beta. (329 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ENSUMAP00000031695annotation not available (241 aa)
ITPRIPLOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor-interacting protein. (470 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (714 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (616 aa)
PSME3Proteasome activator complex subunit 3. (254 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (509 aa)
UNC5BNetrin receptor UNC5B. (913 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
IL19Interleukin-19. (177 aa)
FAIM2Protein lifeguard 2; Belongs to the BI1 family. (319 aa)
GATA1LOW QUALITY PROTEIN: erythroid transcription factor. (438 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
CTTNSrc substrate cortactin. (512 aa)
CSF2Granulocyte-macrophage colony-stimulating factor isoform X1. (277 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (264 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
RNF34E3 ubiquitin-protein ligase RNF34 isoform X1. (376 aa)
GFRALGDNF family receptor alpha-like. (373 aa)
SRCTyrosine-protein kinase. (618 aa)
PEA15Astrocytic phosphoprotein PEA-15. (130 aa)
ZMYND11Zinc finger MYND domain-containing protein 11 isoform X1. (602 aa)
HTTLOW QUALITY PROTEIN: huntingtin. (3048 aa)
RB1CC1RB1-inducible coiled-coil protein 1 isoform X1. (1593 aa)
YAP1LOW QUALITY PROTEIN: yorkie homolog. (457 aa)
ZC3HC1Zinc finger C3HC-type containing 1. (502 aa)
GDNFGlial cell line-derived neurotrophic factor. (241 aa)
GCLMGlutamate--cysteine ligase regulatory subunit. (251 aa)
DDX3YLOW QUALITY PROTEIN: ATP-dependent RNA helicase DDX3X-like; Belongs to the DEAD box helicase family. (704 aa)
RELATranscription factor p65. (585 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa)
IFI6Interferon alpha-inducible protein 6. (259 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (315 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (490 aa)
FAIMFas apoptotic inhibitory molecule 1. (201 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (158 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ITGA6LOW QUALITY PROTEIN: integrin alpha-6; Belongs to the integrin alpha chain family. (1051 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
LGALS3Galectin. (282 aa)
SFRP2Secreted frizzled-related protein 2. (299 aa)
PHIPPH-interacting protein. (1759 aa)
RFFLRing finger and FYVE like domain containing E3 ubiquitin protein ligase. (392 aa)
DDX3XDEAD-box helicase 3 X-linked. (608 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (264 aa)
ARAndrogen receptor. (709 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
SCG2Secretogranin-2. (578 aa)
LMNALamin A/C. (576 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2. (725 aa)
ITGAVLOW QUALITY PROTEIN: integrin alpha-V; Belongs to the integrin alpha chain family. (1056 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
ENSUMAP00000025747annotation not available (76 aa)
LOC103658794Protein lifeguard 2-like; Belongs to the BI1 family. (285 aa)
BIRC6Baculoviral IAP repeat-containing protein 6. (4808 aa)
TMBIM1Transmembrane BAX inhibitor motif containing 1; Belongs to the BI1 family. (311 aa)
ENSUMAP00000027960annotation not available (155 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform X2; Belongs to the peptidase C14A family. (482 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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