40 items (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SFRP1	Secreted frizzled-related protein 1. (305 aa)
	PEA15	Astrocytic phosphoprotein PEA-15. (130 aa)
	TNFRSF12A	Tumor necrosis factor receptor superfamily member 12A. (160 aa)
	RBCK1	ranBP-type and C3HC4-type zinc finger-containing protein 1. (521 aa)
	HTRA2	LOW QUALITY PROTEIN: serine protease HTRA2, mitochondrial. (455 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	BCL10	BCL10 immune signaling adaptor. (234 aa)
	DEDD2	DNA-binding death effector domain-containing protein 2. (327 aa)
	PAK2	Non-specific serine/threonine protein kinase. (524 aa)
	BMPR1B	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
	PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1. (53 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (475 aa)
	PML	Promyelocytic leukemia. (880 aa)
	CYLD	LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family. (948 aa)
	GPER1	G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	PPP2R1B	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (650 aa)
	FADD	FAS-associated death domain protein. (192 aa)
	THBS1	LOW QUALITY PROTEIN: thrombospondin-1. (1168 aa)
	LTBR	Tumor necrosis factor receptor superfamily member 3 isoform X2. (421 aa)
	TNFSF10	Tumor necrosis factor ligand superfamily member 10; Belongs to the tumor necrosis factor family. (286 aa)
	PDIA3	Protein disulfide-isomerase. (458 aa)
	INHBA	Inhibin subunit beta A. (424 aa)
	SKIL	Ski-like protein isoform X2. (664 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (565 aa)
	ENSUMAP00000017147	annotation not available (109 aa)
	PYCARD	Apoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
	WWOX	WW domain-containing oxidoreductase. (377 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	STK3	Serine/threonine-protein kinase 3. (497 aa)
	TIMP3	TIMP metallopeptidase inhibitor 3. (211 aa)
	SRPX	Sushi repeat containing protein X-linked. (463 aa)
	ATF3	Cyclic AMP-dependent transcription factor ATF-3. (181 aa)
	ZSWIM2	E3 ubiquitin-protein ligase ZSWIM2. (633 aa)
	RIPK1	Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
	G0S2	G0/G1 switch protein 2. (106 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (494 aa)
	NF1	Neurofibromin. (2862 aa)
	PTPRC	Receptor-type tyrosine-protein phosphatase C isoform X1. (1268 aa)
	STK4	Serine/threonine-protein kinase 4. (496 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGT	GPER1	ENSUMAP00000006540	ENSUMAP00000008264	Angiotensinogen; Belongs to the serpin family.	G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.592
ATF3	TNF	ENSUMAP00000024813	ENSUMAP00000020603	Cyclic AMP-dependent transcription factor ATF-3.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.407
BCL10	CYLD	ENSUMAP00000002851	ENSUMAP00000007602	BCL10 immune signaling adaptor.	LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family.	0.506
BCL10	TNF	ENSUMAP00000002851	ENSUMAP00000020603	BCL10 immune signaling adaptor.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.411
BCL10	TRAF2	ENSUMAP00000002851	ENSUMAP00000032192	BCL10 immune signaling adaptor.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.470
BID	FADD	ENSUMAP00000015536	ENSUMAP00000009429	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	FAS-associated death domain protein.	0.731
BMPR1B	INHBA	ENSUMAP00000005818	ENSUMAP00000013376	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Inhibin subunit beta A.	0.645
CAV1	PDIA3	ENSUMAP00000002463	ENSUMAP00000011131	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Protein disulfide-isomerase.	0.466
CAV1	PTEN	ENSUMAP00000002463	ENSUMAP00000016792	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.610
CAV1	TIMP3	ENSUMAP00000002463	ENSUMAP00000023603	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	TIMP metallopeptidase inhibitor 3.	0.566
CAV1	TNF	ENSUMAP00000002463	ENSUMAP00000020603	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.443
CYLD	BCL10	ENSUMAP00000007602	ENSUMAP00000002851	LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family.	BCL10 immune signaling adaptor.	0.506
CYLD	FADD	ENSUMAP00000007602	ENSUMAP00000009429	LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family.	FAS-associated death domain protein.	0.799
CYLD	RBCK1	ENSUMAP00000007602	ENSUMAP00000001068	LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family.	ranBP-type and C3HC4-type zinc finger-containing protein 1.	0.641
CYLD	RIPK1	ENSUMAP00000007602	ENSUMAP00000025734	LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family.	Receptor-interacting serine/threonine-protein kinase 1.	0.990
CYLD	TNF	ENSUMAP00000007602	ENSUMAP00000020603	LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.840
CYLD	TRAF2	ENSUMAP00000007602	ENSUMAP00000032192	LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.747
ENSUMAP00000017147	LTBR	ENSUMAP00000017147	ENSUMAP00000009795	annotation not available	Tumor necrosis factor receptor superfamily member 3 isoform X2.	0.451
ENSUMAP00000017147	TNF	ENSUMAP00000017147	ENSUMAP00000020603	annotation not available	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.417
ENSUMAP00000017147	TRAF2	ENSUMAP00000017147	ENSUMAP00000032192	annotation not available	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.532