19 items (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ZC3HC1	Zinc finger C3HC-type containing 1. (502 aa)
	GDNF	Glial cell line-derived neurotrophic factor. (241 aa)
	UNC5B	Netrin receptor UNC5B. (913 aa)
	GATA1	LOW QUALITY PROTEIN: erythroid transcription factor. (438 aa)
	CSF2	Granulocyte-macrophage colony-stimulating factor isoform X1. (277 aa)
	MAPK7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (264 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	GFRAL	GDNF family receptor alpha-like. (373 aa)
	EYA2	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (509 aa)
	EYA4	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (616 aa)
	STRADB	STE20-related kinase adapter protein beta. (329 aa)
	ENSUMAP00000025747	annotation not available (76 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
	RIPK1	Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	IL7	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (158 aa)
	SGK3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (490 aa)
	IFI6	Interferon alpha-inducible protein 6. (259 aa)
	EYA3	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSF2	IL7	ENSUMAP00000009073	ENSUMAP00000020354	Granulocyte-macrophage colony-stimulating factor isoform X1.	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family.	0.755
CSF2	TNF	ENSUMAP00000009073	ENSUMAP00000020603	Granulocyte-macrophage colony-stimulating factor isoform X1.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.831
ENSUMAP00000025747	EYA4	ENSUMAP00000025747	ENSUMAP00000033872	annotation not available	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.432
ENSUMAP00000025747	GDNF	ENSUMAP00000025747	ENSUMAP00000010972	annotation not available	Glial cell line-derived neurotrophic factor.	0.566
EYA1	EYA2	ENSUMAP00000025735	ENSUMAP00000034902	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.420
EYA1	EYA3	ENSUMAP00000025735	ENSUMAP00000015224	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.421
EYA1	EYA4	ENSUMAP00000025735	ENSUMAP00000033872	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.440
EYA1	GDNF	ENSUMAP00000025735	ENSUMAP00000010972	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Glial cell line-derived neurotrophic factor.	0.566
EYA2	EYA1	ENSUMAP00000034902	ENSUMAP00000025735	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.420
EYA2	EYA3	ENSUMAP00000034902	ENSUMAP00000015224	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.527
EYA2	EYA4	ENSUMAP00000034902	ENSUMAP00000033872	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.514
EYA3	EYA1	ENSUMAP00000015224	ENSUMAP00000025735	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.421
EYA3	EYA2	ENSUMAP00000015224	ENSUMAP00000034902	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.527
EYA3	EYA4	ENSUMAP00000015224	ENSUMAP00000033872	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.509
EYA4	ENSUMAP00000025747	ENSUMAP00000033872	ENSUMAP00000025747	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	annotation not available	0.432
EYA4	EYA1	ENSUMAP00000033872	ENSUMAP00000025735	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.440
EYA4	EYA2	ENSUMAP00000033872	ENSUMAP00000034902	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.514
EYA4	EYA3	ENSUMAP00000033872	ENSUMAP00000015224	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.509
FGF10	GDNF	ENSUMAP00000007657	ENSUMAP00000010972	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Glial cell line-derived neurotrophic factor.	0.592
FGF10	TNF	ENSUMAP00000007657	ENSUMAP00000020603	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.512