(10 nodes) Sin3 complex network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (498 aa)
	SINHCAF	SIN3-HDAC complex associated factor. (221 aa)
	SIN3A	SIN3 transcription regulator family member A. (1274 aa)
	ARID4B	AT-rich interactive domain-containing protein 4B. (1290 aa)
	MORF4L1	Mortality factor 4-like protein 1. (351 aa)
	PHF12-2	PHD finger protein 12. (125 aa)
	PHF12	PHD finger protein 12. (257 aa)
	SIN3B	Paired amphipathic helix protein Sin3b. (880 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (458 aa)
	ARID4A	AT-rich interactive domain-containing protein 4A isoform X3. (1286 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARID4A	ARID4B	ENSUMAP00000023009	ENSUMAP00000009417	AT-rich interactive domain-containing protein 4A isoform X3.	AT-rich interactive domain-containing protein 4B.	0.871
ARID4A	HDAC1	ENSUMAP00000023009	ENSUMAP00000011136	AT-rich interactive domain-containing protein 4A isoform X3.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.925
ARID4A	HDAC2	ENSUMAP00000023009	ENSUMAP00000035417	AT-rich interactive domain-containing protein 4A isoform X3.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.925
ARID4A	PHF12	ENSUMAP00000023009	ENSUMAP00000015837	AT-rich interactive domain-containing protein 4A isoform X3.	PHD finger protein 12.	0.838
ARID4A	PHF12-2	ENSUMAP00000023009	ENSUMAP00000015790	AT-rich interactive domain-containing protein 4A isoform X3.	PHD finger protein 12.	0.838
ARID4A	SIN3A	ENSUMAP00000023009	ENSUMAP00000004652	AT-rich interactive domain-containing protein 4A isoform X3.	SIN3 transcription regulator family member A.	0.950
ARID4A	SIN3B	ENSUMAP00000023009	ENSUMAP00000016851	AT-rich interactive domain-containing protein 4A isoform X3.	Paired amphipathic helix protein Sin3b.	0.949
ARID4A	SINHCAF	ENSUMAP00000023009	ENSUMAP00000002960	AT-rich interactive domain-containing protein 4A isoform X3.	SIN3-HDAC complex associated factor.	0.708
ARID4B	ARID4A	ENSUMAP00000009417	ENSUMAP00000023009	AT-rich interactive domain-containing protein 4B.	AT-rich interactive domain-containing protein 4A isoform X3.	0.871
ARID4B	HDAC1	ENSUMAP00000009417	ENSUMAP00000011136	AT-rich interactive domain-containing protein 4B.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.923
ARID4B	HDAC2	ENSUMAP00000009417	ENSUMAP00000035417	AT-rich interactive domain-containing protein 4B.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.923
ARID4B	PHF12	ENSUMAP00000009417	ENSUMAP00000015837	AT-rich interactive domain-containing protein 4B.	PHD finger protein 12.	0.842
ARID4B	PHF12-2	ENSUMAP00000009417	ENSUMAP00000015790	AT-rich interactive domain-containing protein 4B.	PHD finger protein 12.	0.842
ARID4B	SIN3A	ENSUMAP00000009417	ENSUMAP00000004652	AT-rich interactive domain-containing protein 4B.	SIN3 transcription regulator family member A.	0.967
ARID4B	SIN3B	ENSUMAP00000009417	ENSUMAP00000016851	AT-rich interactive domain-containing protein 4B.	Paired amphipathic helix protein Sin3b.	0.948
ARID4B	SINHCAF	ENSUMAP00000009417	ENSUMAP00000002960	AT-rich interactive domain-containing protein 4B.	SIN3-HDAC complex associated factor.	0.639
HDAC1	ARID4A	ENSUMAP00000011136	ENSUMAP00000023009	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	AT-rich interactive domain-containing protein 4A isoform X3.	0.925
HDAC1	ARID4B	ENSUMAP00000011136	ENSUMAP00000009417	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	AT-rich interactive domain-containing protein 4B.	0.923
HDAC1	HDAC2	ENSUMAP00000011136	ENSUMAP00000035417	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.994
HDAC1	MORF4L1	ENSUMAP00000011136	ENSUMAP00000014948	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	Mortality factor 4-like protein 1.	0.791