STRINGSTRING
CDH7 CDH7 PIK3C3 PIK3C3 GOLGA3 GOLGA3 DNAJA3 DNAJA3 WNT2 WNT2 PIK3C2G PIK3C2G SOCS2 SOCS2 STXBP5 STXBP5 PIK3C2B PIK3C2B HPCAL1 HPCAL1 C16orf89 C16orf89 CRKL CRKL CDK17 CDK17 TDGF1 TDGF1 ENSUMAP00000008071 ENSUMAP00000008071 RNF112 RNF112 USO1 USO1 GNG7 GNG7 MCF2L2 MCF2L2 GFRA2 GFRA2 GNG4 GNG4 ENSUMAP00000009516 ENSUMAP00000009516 GNA15 GNA15 ENSUMAP00000009735 ENSUMAP00000009735 GBA2 GBA2 GNB4 GNB4 GNAL GNAL UBXN6 UBXN6 PIK3CA PIK3CA HPCA HPCA CDH15 CDH15 NDUFAF5 NDUFAF5 SYAP1 SYAP1 CDK16 CDK16 GRAMD2A GRAMD2A FES FES ZFYVE1 ZFYVE1 MMP27 MMP27 RGS6 RGS6 WDR81 WDR81 HIP1 HIP1 GNAI3 GNAI3 LOC103679524 LOC103679524 SYTL4 SYTL4 SYTL3 SYTL3 BECN2 BECN2 DOC2A DOC2A GNB2 GNB2 ARMC12 ARMC12 RPH3A RPH3A PIK3R2 PIK3R2 KPNA7 KPNA7 ESYT2 ESYT2 CCDC115 CCDC115 WNT2B WNT2B GNG2 GNG2 GNAI1 GNAI1 GNAT3 GNAT3 CDH24 CDH24 MUC16 MUC16 COQ8A COQ8A ENSUMAP00000020007 ENSUMAP00000020007 EPN3 EPN3 PIK3CB PIK3CB MGLL MGLL ESYT3 ESYT3 ENSUMAP00000020440 ENSUMAP00000020440 FER FER SNX16 SNX16 SOX10 SOX10 RAB7A RAB7A ACADVL ACADVL MICALL1 MICALL1 USP8 USP8 USP50 USP50 WDR91 WDR91 TEPSIN TEPSIN GNGT2 GNGT2 FAM92A FAM92A CDH6 CDH6 SYK SYK ATG14 ATG14 DUSP18 DUSP18 CDH10 CDH10 MTMR3 MTMR3 TIAM1 TIAM1 SYTL5 SYTL5 NCALD NCALD PIK3R4 PIK3R4 PIK3R6 PIK3R6 PIK3R5 PIK3R5 VAC14 VAC14 TAMM41 TAMM41 KPNA2 KPNA2 SERPINE2 SERPINE2 PIK3CG PIK3CG CTNND1 CTNND1 CDH1 CDH1 GNB5 GNB5 YES1 YES1 GNGT1 GNGT1 GNG11 GNG11 COQ8B COQ8B SNAP91 SNAP91 ATP23 ATP23 RGS1 RGS1 S100A6 S100A6 CDH11 CDH11 GNG13 GNG13 DUSP21 DUSP21 LOC103671807 LOC103671807 AAK1 AAK1 MCF2L MCF2L ENSUMAP00000029435 ENSUMAP00000029435 OTULINL OTULINL CISH CISH GNAI2 GNAI2 GNAT1 GNAT1 SRMS SRMS ENSUMAP00000030752 ENSUMAP00000030752 RHOA RHOA PSD PSD MYZAP MYZAP ENSUMAP00000032829 ENSUMAP00000032829 LOC103679927 LOC103679927 EHD2 EHD2 ENSUMAP00000033059 ENSUMAP00000033059 P3R3URF P3R3URF SYTL2 SYTL2 PIK3R3 PIK3R3 PIK3CD PIK3CD ERRFI1 ERRFI1 ENSUMAP00000034720 ENSUMAP00000034720 ENSUMAP00000034728 ENSUMAP00000034728 PDE4A PDE4A OLFM2 OLFM2 ENSUMAP00000034969 ENSUMAP00000034969 FARP1 FARP1 WDFY3 WDFY3 FYN FYN GNAZ GNAZ UBC UBC ZC3H12A ZC3H12A PLEKHA4 PLEKHA4 FKBP1A FKBP1A GNAO1 GNAO1 GNB1 GNB1 TGM3 TGM3 GNAS GNAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDH7Cadherin-7; Cadherins are calcium-dependent cell adhesion proteins. (760 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (888 aa)
GOLGA3Golgin subfamily A member 3. (1511 aa)
DNAJA3dnaJ homolog subfamily A member 3, mitochondrial. (496 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
PIK3C2GPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1; Belongs to the PI3/PI4-kinase family. (1486 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
STXBP5LOW QUALITY PROTEIN: syntaxin-binding protein 5. (1103 aa)
PIK3C2BPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; Belongs to the PI3/PI4-kinase family. (1636 aa)
HPCAL1Hippocalcin like 1. (276 aa)
C16orf89UPF0764 protein C16orf89 homolog isoform X1. (372 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
CDK17Cyclin-dependent kinase 17. (523 aa)
TDGF1Teratocarcinoma-derived growth factor 1. (184 aa)
ENSUMAP00000008071annotation not available (279 aa)
RNF112RING finger protein 112. (425 aa)
USO1General vesicular transport factor p115 isoform X1. (970 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
MCF2L2LOW QUALITY PROTEIN: probable guanine nucleotide exchange factor MCF2L2. (1056 aa)
GFRA2GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. (464 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
ENSUMAP00000009516annotation not available (554 aa)
GNA15Guanine nucleotide-binding protein subunit alpha-15. (351 aa)
ENSUMAP00000009735annotation not available (166 aa)
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (905 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4 isoform X1. (340 aa)
GNALGuanine nucleotide-binding protein G(Olf) subunit alpha. (380 aa)
UBXN6LOW QUALITY PROTEIN: UBX domain-containing protein 6. (420 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
HPCANeuron-specific calcium-binding protein hippocalcin. (193 aa)
CDH15Cadherin-15-like; Cadherins are calcium-dependent cell adhesion proteins. (693 aa)
NDUFAF5NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5. (344 aa)
SYAP1Synapse-associated protein 1. (351 aa)
CDK16LOW QUALITY PROTEIN: cyclin-dependent kinase 16. (525 aa)
GRAMD2AGRAM domain-containing protein 2 isoform X2. (354 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (777 aa)
ZFYVE1LOW QUALITY PROTEIN: zinc finger FYVE domain-containing protein 1. (823 aa)
MMP27Matrix metalloproteinase-27 isoform X1. (513 aa)
RGS6Regulator of G-protein signaling 6 isoform X2. (509 aa)
WDR81LOW QUALITY PROTEIN: WD repeat-containing protein 81. (1860 aa)
HIP1Huntingtin-interacting protein 1. (1000 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
LOC103679524Double C2-like domain-containing protein. (387 aa)
SYTL4Synaptotagmin-like protein 4 isoform X2. (671 aa)
SYTL3Synaptotagmin-like protein 3 isoform X1. (610 aa)
BECN2Beclin-2. (433 aa)
DOC2ALOW QUALITY PROTEIN: double C2-like domain-containing protein alpha. (383 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2. (340 aa)
ARMC12Armadillo repeat-containing protein 12. (340 aa)
RPH3Arabphilin-3A isoform X2. (673 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (561 aa)
KPNA7Importin subunit alpha; Functions in nuclear protein import. (485 aa)
ESYT2Extended synaptotagmin-2. (755 aa)
CCDC115Coiled-coil domain-containing protein 115. (201 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (299 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (332 aa)
GNAT3Guanine nucleotide-binding protein G(T) subunit alpha-3 isoform X2. (354 aa)
CDH24Cadherin-24. (741 aa)
MUC16LOW QUALITY PROTEIN: mucin-16. (259 aa)
COQ8AChaperone activity of bc1 complex-like, mitochondrial. (603 aa)
ENSUMAP00000020007Guanine nucleotide-binding protein G(s) subunit alpha. (68 aa)
EPN3Epsin-3. (294 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
MGLLMonoglyceride lipase isoform X1. (313 aa)
ESYT3Extended synaptotagmin-3. (834 aa)
ENSUMAP00000020440annotation not available (165 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (410 aa)
SNX16Sorting nexin-16 isoform X1. (344 aa)
SOX10Transcription factor SOX-10. (305 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
ACADVLLOW QUALITY PROTEIN: very long-chain specific acyl-CoA dehydrogenase, mitochondrial. (700 aa)
MICALL1LOW QUALITY PROTEIN: MICAL-like protein 1. (773 aa)
USP8LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 8; Belongs to the peptidase C19 family. (1095 aa)
USP50Inactive ubiquitin carboxyl-terminal hydrolase 50; Belongs to the peptidase C19 family. (366 aa)
WDR91WD repeat-containing protein 91 isoform X1. (730 aa)
TEPSINAP-4 complex accessory subunit tepsin. (587 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
FAM92AProtein FAM92A1. (285 aa)
CDH6Cadherin-6; Cadherins are calcium-dependent cell adhesion proteins. (800 aa)
SYKTyrosine-protein kinase SYK; Belongs to the protein kinase superfamily. Tyr protein kinase family. (610 aa)
ATG14Beclin 1-associated autophagy-related key regulator. (430 aa)
DUSP18Dual specificity protein phosphatase 18; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (188 aa)
CDH10Cadherin-10; Cadherins are calcium-dependent cell adhesion proteins. (788 aa)
MTMR3Myotubularin-related protein 3 isoform X1. (1229 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1. (1457 aa)
SYTL5Synaptotagmin-like protein 5 isoform X1. (754 aa)
NCALDNeurocalcin-delta. (193 aa)
PIK3R4Phosphoinositide 3-kinase regulatory subunit 4. (1358 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (743 aa)
PIK3R5LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 5. (211 aa)
VAC14Protein VAC14 homolog. (717 aa)
TAMM41Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. (337 aa)
KPNA2Importin subunit alpha; Functions in nuclear protein import. (529 aa)
SERPINE2Glia-derived nexin; Belongs to the serpin family. (397 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1090 aa)
CTNND1Catenin delta-1 isoform X1. (932 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (881 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5. (383 aa)
YES1Tyrosine-protein kinase. (541 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (104 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
COQ8BaarF domain-containing protein kinase 4. (525 aa)
SNAP91Clathrin coat assembly protein AP180. (896 aa)
ATP23Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. (174 aa)
RGS1Regulator of G-protein signaling 1. (210 aa)
S100A6Protein S100; Belongs to the S-100 family. (90 aa)
CDH11Cadherin-11; Cadherins are calcium-dependent cell adhesion proteins. (796 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
DUSP21Dual specificity protein phosphatase 21; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (189 aa)
LOC103671807Uncharacterized protein FLJ45252-like. (607 aa)
AAK1AP2-associated protein kinase 1. (516 aa)
MCF2LGuanine nucleotide exchange factor DBS. (867 aa)
ENSUMAP00000029435annotation not available (227 aa)
OTULINLOTU deubiquitinase with linear linkage specificity like. (327 aa)
CISHCytokine-inducible SH2-containing protein. (224 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (412 aa)
GNAT1LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(T) subunit alpha-1. (337 aa)
SRMSTyrosine-protein kinase. (581 aa)
ENSUMAP00000030752Polyubiquitin-like. (77 aa)
RHOARas homolog family member A. (193 aa)
PSDPH and SEC7 domain-containing protein 1. (1009 aa)
MYZAPMyocardial zonula adherens protein. (444 aa)
ENSUMAP00000032829annotation not available (407 aa)
LOC103679927Ficolin-1-like isoform X3. (326 aa)
EHD2EH domain-containing protein 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (370 aa)
ENSUMAP00000033059annotation not available (226 aa)
P3R3URFPIK3R3 upstream reading frame. (95 aa)
SYTL2Synaptotagmin-like protein 2 isoform X7. (952 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PIK3CDLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Belongs to the PI3/PI4-kinase family. (855 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (98 aa)
ENSUMAP00000034720annotation not available (151 aa)
ENSUMAP00000034728annotation not available (91 aa)
PDE4APhosphodiesterase. (589 aa)
OLFM2Noelin-2 isoform X2. (442 aa)
ENSUMAP00000034969annotation not available (120 aa)
FARP1FERM, RhoGEF and pleckstrin domain-containing protein 1. (1019 aa)
WDFY3LOW QUALITY PROTEIN: WD repeat and FYVE domain-containing protein 3. (3510 aa)
FYNTyrosine-protein kinase. (576 aa)
GNAZGuanine nucleotide-binding protein G(Z) subunit alpha. (303 aa)
UBCLOW QUALITY PROTEIN: polyubiquitin-B. (305 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (582 aa)
PLEKHA4LOW QUALITY PROTEIN: pleckstrin homology domain-containing family A member 4. (756 aa)
FKBP1APeptidylprolyl isomerase. (95 aa)
GNAO1Guanine nucleotide-binding protein G(O) subunit alpha-like. (335 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1. (368 aa)
TGM3LOW QUALITY PROTEIN: protein-glutamine gamma-glutamyltransferase E. (735 aa)
GNASGuanine nucleotide-binding protein G(S) subunit alpha isoform X1. (672 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.