(82 nodes) Membrane raft network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CAVIN3	Protein kinase C delta-binding protein. (242 aa)
	SCARB1	LOW QUALITY PROTEIN: scavenger receptor class B member 1; Belongs to the CD36 family. (500 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (106 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	MAPK1	Mitogen-activated protein kinase. (363 aa)
	STOM	Erythrocyte band 7 integral membrane protein. (233 aa)
	EMP2	Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
	ABCG2	ATP-binding cassette sub-family G member 2 isoform X1. (649 aa)
	CD4	T-cell surface glycoprotein CD4. (460 aa)
	LAMTOR3	Ragulator complex protein LAMTOR3 isoform X1. (150 aa)
	PLPP2	Lipid phosphate phosphohydrolase 2. (482 aa)
	TEK	TEK receptor tyrosine kinase. (1124 aa)
	CORO1C	Coronin; Belongs to the WD repeat coronin family. (474 aa)
	SELPLG	P-selectin glycoprotein ligand 1. (440 aa)
	ENSUMAP00000008134	annotation not available (95 aa)
	STIM1	Stromal interaction molecule 1 isoform X1. (716 aa)
	FAIM2	Protein lifeguard 2; Belongs to the BI1 family. (319 aa)
	LAMTOR1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (174 aa)
	GHSR	Growth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (368 aa)
	ERLIN2	Erlin-2 isoform X1. (337 aa)
	SLC38A9	Putative sodium-coupled neutral amino acid transporter 9 isoform X1. (559 aa)
	PLPP1	Lipid phosphate phosphohydrolase 1 isoform X1. (286 aa)
	PTCH1	Protein patched homolog 1. (1388 aa)
	LYN	Tyrosine-protein kinase. (512 aa)
	LAMTOR4	Ragulator complex protein LAMTOR4. (91 aa)
	GPC1	Glypican-1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (531 aa)
	CLN3	Battenin. (485 aa)
	MAPK3	Mitogen-activated protein kinase. (354 aa)
	ASAH2	Neutral ceramidase. (777 aa)
	MS4A4A	Membrane-spanning 4-domains subfamily A member 4A. (201 aa)
	MS4A1	Membrane spanning 4-domains A1. (297 aa)
	MS4A15	Membrane-spanning 4-domains subfamily A member 15 isoform X1. (240 aa)
	FLOT2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (515 aa)
	PLVAP	Plasmalemma vesicle-associated protein. (441 aa)
	CLN6	Ceroid-lipofuscinosis neuronal protein 6. (436 aa)
	BTK	Tyrosine-protein kinase. (681 aa)
	PLSCR1	Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (323 aa)
	LOC103681498	Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (334 aa)
	LAMTOR5	Ragulator complex protein LAMTOR5. (89 aa)
	CD36	Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family. (472 aa)
	LRP4	Low-density lipoprotein receptor-related protein 4. (1742 aa)
	PAG1	LOW QUALITY PROTEIN: phosphoprotein associated with glycosphingolipid-enriched microdomains 1. (418 aa)
	ENSUMAP00000022411	annotation not available (78 aa)
	ENSUMAP00000022519	annotation not available (124 aa)
	HTR2A	5-hydroxytryptamine receptor 2A. (470 aa)
	PPT1	Palmitoyl-protein thioesterase 1. (306 aa)
	RANGRF	Ran guanine nucleotide release factor. (175 aa)
	ENSUMAP00000024345	annotation not available (140 aa)
	ADTRP	Androgen-dependent TFPI-regulating protein. (246 aa)
	RFTN1	Raftlin, lipid raft linker 1. (560 aa)
	CTNND1	Catenin delta-1 isoform X1. (932 aa)
	LAMTOR2	Ragulator complex protein LAMTOR2. (86 aa)
	ENSUMAP00000025261	annotation not available (64 aa)
	MLC1	Membrane protein MLC1. (356 aa)
	CDH1	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (881 aa)
	LOC103658794	Protein lifeguard 2-like; Belongs to the BI1 family. (285 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	STOML3	Stomatin-like protein 3. (258 aa)
	FLOT1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
	CAVIN2	Serum deprivation-response protein. (425 aa)
	ENSUMAP00000028427	annotation not available (90 aa)
	MAL2	Mal, T cell differentiation protein 2 (gene/pseudogene). (108 aa)
	BVES	Blood vessel epicardial substance. (360 aa)
	RFTN2	Raftlin family member 2. (499 aa)
	SORBS1	Sorbin and SH3 domain-containing protein 1 isoform X5. (713 aa)
	PDPN	Podoplanin. (190 aa)
	HYAL2	Hyaluronidase. (472 aa)
	PLPP3	Lipid phosphate phosphohydrolase 3. (273 aa)
	ANXA13	Annexin. (357 aa)
	LRP8	LDL receptor related protein 8. (925 aa)
	ADCY8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1163 aa)
	CBLC	E3 ubiquitin-protein ligase CBL-C. (437 aa)
	EHD2	EH domain-containing protein 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (370 aa)
	ENSUMAP00000033059	annotation not available (226 aa)
	LRRK2	LOW QUALITY PROTEIN: leucine-rich repeat serine/threonine-protein kinase 2. (2513 aa)
	PTGIS	Prostacyclin synthase; Belongs to the cytochrome P450 family. (485 aa)
	SMPD1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa)
	TPP1	Tripeptidyl-peptidase 1. (572 aa)
	ENSUMAP00000000253	annotation not available (90 aa)
	CD48	CD48 antigen. (245 aa)
	CDHR2	Cadherin-related family member 2. (755 aa)
	CAVIN1	Polymerase I and transcript release factor. (355 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCG2	CDH1	ENSUMAP00000005441	ENSUMAP00000025952	ATP-binding cassette sub-family G member 2 isoform X1.	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	0.523
ASAH2	PLPP1	ENSUMAP00000015359	ENSUMAP00000012538	Neutral ceramidase.	Lipid phosphate phosphohydrolase 1 isoform X1.	0.907
ASAH2	PLPP2	ENSUMAP00000015359	ENSUMAP00000006555	Neutral ceramidase.	Lipid phosphate phosphohydrolase 2.	0.907
ASAH2	PLPP3	ENSUMAP00000015359	ENSUMAP00000030551	Neutral ceramidase.	Lipid phosphate phosphohydrolase 3.	0.907
ASAH2	SMPD1	ENSUMAP00000015359	ENSUMAP00000000992	Neutral ceramidase.	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.	0.949
BTK	CD4	ENSUMAP00000016522	ENSUMAP00000006361	Tyrosine-protein kinase.	T-cell surface glycoprotein CD4.	0.430
BTK	GHSR	ENSUMAP00000016522	ENSUMAP00000010746	Tyrosine-protein kinase.	Growth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family.	0.495
BTK	LYN	ENSUMAP00000016522	ENSUMAP00000013226	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.973
BTK	PAG1	ENSUMAP00000016522	ENSUMAP00000020460	Tyrosine-protein kinase.	LOW QUALITY PROTEIN: phosphoprotein associated with glycosphingolipid-enriched microdomains 1.	0.403
CAV1	CAV2	ENSUMAP00000002463	ENSUMAP00000002454	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.999
CAV1	CAV3	ENSUMAP00000002463	ENSUMAP00000026521	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.958
CAV1	CAVIN1	ENSUMAP00000002463	ENSUMAP00000034772	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Polymerase I and transcript release factor.	0.898
CAV1	CAVIN2	ENSUMAP00000002463	ENSUMAP00000028274	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Serum deprivation-response protein.	0.593
CAV1	CAVIN3	ENSUMAP00000002463	ENSUMAP00000001000	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Protein kinase C delta-binding protein.	0.561
CAV1	CD36	ENSUMAP00000002463	ENSUMAP00000019259	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family.	0.466
CAV1	CDH1	ENSUMAP00000002463	ENSUMAP00000025952	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins.	0.675
CAV1	EHD2	ENSUMAP00000002463	ENSUMAP00000033058	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	EH domain-containing protein 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.557
CAV1	ENSUMAP00000022411	ENSUMAP00000002463	ENSUMAP00000022411	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	annotation not available	0.418
CAV1	ENSUMAP00000033059	ENSUMAP00000002463	ENSUMAP00000033059	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	annotation not available	0.557
CAV1	FLOT1	ENSUMAP00000002463	ENSUMAP00000027092	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.770