(14 nodes) Death domain network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DTHD1	Death domain-containing protein 1. (905 aa)
	EDARADD	ectodysplasin-A receptor-associated adapter protein. (208 aa)
	FAS	Tumor necrosis factor receptor superfamily member 6 isoform X1. (351 aa)
	UNC5CL	LOW QUALITY PROTEIN: UNC5C-like protein. (492 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
	UNC5C	Netrin receptor UNC5C isoform X2. (950 aa)
	LOC103674871	Death domain-containing membrane protein NRADD-like. (248 aa)
	IRAK2	Interleukin-1 receptor-associated kinase-like 2. (632 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (250 aa)
	TNFRSF11B	Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
	TRADD	Tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2. (314 aa)
	THOC1	THO complex subunit 1. (657 aa)
	RIPK1	Receptor-interacting serine/threonine-protein kinase 1. (665 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRADD	TRADD	ENSUMAP00000003794	ENSUMAP00000027876	CASP2 and RIPK1 domain containing adaptor with death domain.	Tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2.	0.445
FAS	RIPK1	ENSUMAP00000016893	ENSUMAP00000025734	Tumor necrosis factor receptor superfamily member 6 isoform X1.	Receptor-interacting serine/threonine-protein kinase 1.	0.831
FAS	TRADD	ENSUMAP00000016893	ENSUMAP00000027876	Tumor necrosis factor receptor superfamily member 6 isoform X1.	Tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2.	0.974
IRAK2	MYD88	ENSUMAP00000025559	ENSUMAP00000007288	Interleukin-1 receptor-associated kinase-like 2.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.983
IRAK2	NFKB1	ENSUMAP00000025559	ENSUMAP00000006647	Interleukin-1 receptor-associated kinase-like 2.	Nuclear factor NF-kappa-B p105 subunit isoform X1.	0.457
IRAK2	RIPK1	ENSUMAP00000025559	ENSUMAP00000025734	Interleukin-1 receptor-associated kinase-like 2.	Receptor-interacting serine/threonine-protein kinase 1.	0.413
MYD88	IRAK2	ENSUMAP00000007288	ENSUMAP00000025559	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Interleukin-1 receptor-associated kinase-like 2.	0.983
MYD88	NFKB1	ENSUMAP00000007288	ENSUMAP00000006647	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Nuclear factor NF-kappa-B p105 subunit isoform X1.	0.610
MYD88	RIPK1	ENSUMAP00000007288	ENSUMAP00000025734	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Receptor-interacting serine/threonine-protein kinase 1.	0.567
MYD88	TRADD	ENSUMAP00000007288	ENSUMAP00000027876	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	Tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2.	0.557
NFKB1	IRAK2	ENSUMAP00000006647	ENSUMAP00000025559	Nuclear factor NF-kappa-B p105 subunit isoform X1.	Interleukin-1 receptor-associated kinase-like 2.	0.457
NFKB1	MYD88	ENSUMAP00000006647	ENSUMAP00000007288	Nuclear factor NF-kappa-B p105 subunit isoform X1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.610
NFKB1	RIPK1	ENSUMAP00000006647	ENSUMAP00000025734	Nuclear factor NF-kappa-B p105 subunit isoform X1.	Receptor-interacting serine/threonine-protein kinase 1.	0.423
RIPK1	FAS	ENSUMAP00000025734	ENSUMAP00000016893	Receptor-interacting serine/threonine-protein kinase 1.	Tumor necrosis factor receptor superfamily member 6 isoform X1.	0.831
RIPK1	IRAK2	ENSUMAP00000025734	ENSUMAP00000025559	Receptor-interacting serine/threonine-protein kinase 1.	Interleukin-1 receptor-associated kinase-like 2.	0.413
RIPK1	MYD88	ENSUMAP00000025734	ENSUMAP00000007288	Receptor-interacting serine/threonine-protein kinase 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.567
RIPK1	NFKB1	ENSUMAP00000025734	ENSUMAP00000006647	Receptor-interacting serine/threonine-protein kinase 1.	Nuclear factor NF-kappa-B p105 subunit isoform X1.	0.423
RIPK1	TRADD	ENSUMAP00000025734	ENSUMAP00000027876	Receptor-interacting serine/threonine-protein kinase 1.	Tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2.	0.999
TRADD	CRADD	ENSUMAP00000027876	ENSUMAP00000003794	Tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2.	CASP2 and RIPK1 domain containing adaptor with death domain.	0.445
TRADD	FAS	ENSUMAP00000027876	ENSUMAP00000016893	Tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2.	Tumor necrosis factor receptor superfamily member 6 isoform X1.	0.974