(52 nodes) SH2 domain network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LYN	Tyrosine-protein kinase. (512 aa)
	SH2D7	SH2 domain-containing protein 7 isoform X2. (464 aa)
	SHB	SH2 domain-containing adapter protein B. (348 aa)
	SUPT6H	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1723 aa)
	SLA	Src-like-adapter isoform X2. (276 aa)
	CHN2	Chimaerin; GTPase-activating protein for p21-rac. (458 aa)
	TXK	Tyrosine-protein kinase. (527 aa)
	TEC	Tyrosine-protein kinase. (631 aa)
	ITK	Tyrosine-protein kinase. (620 aa)
	SOCS2	Suppressor of cytokine signaling 2. (198 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (303 aa)
	SRC	Tyrosine-protein kinase. (618 aa)
	FRK	Tyrosine-protein kinase. (515 aa)
	SLA2	Src-like-adapter 2 isoform X1. (276 aa)
	SH2D3C	SH2 domain-containing protein 3C isoform X1. (861 aa)
	HSH2D	Hematopoietic SH2 domain-containing protein isoform X1. (354 aa)
	DAPP1	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide. (280 aa)
	RASA1	Ras GTPase-activating protein 1. (969 aa)
	BMX	Tyrosine-protein kinase. (655 aa)
	LOC103658503	GRB2-related adapter protein. (225 aa)
	BTK	Tyrosine-protein kinase. (681 aa)
	GRB14	Growth factor receptor-bound protein 14. (519 aa)
	VAV3	Guanine nucleotide exchange factor VAV3. (782 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (845 aa)
	STAP1	Signal-transducing adaptor protein 1 isoform X1. (293 aa)
	SH2D4B	SH2 domain-containing protein 4B. (439 aa)
	GRAP2	GRB2 related adaptor protein 2. (316 aa)
	SHC4	SHC-transforming protein 4. (630 aa)
	INPP5D	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1137 aa)
	SOCS4	Suppressor of cytokine signaling 4. (439 aa)
	STAT2	Signal transducer and activator of transcription. (848 aa)
	SH2D2A	SH2 domain-containing protein 2A isoform X4. (414 aa)
	STAT6	Signal transducer and activator of transcription. (846 aa)
	TNS4	Tensin-4. (705 aa)
	SHF	SH2 domain-containing adapter protein F isoform X2. (239 aa)
	YES1	Tyrosine-protein kinase. (541 aa)
	SHC1	LOW QUALITY PROTEIN: SHC-transforming protein 1. (569 aa)
	ABL2	Tyrosine-protein kinase. (1137 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	BLK	Tyrosine-protein kinase. (500 aa)
	CISH	Cytokine-inducible SH2-containing protein. (224 aa)
	SH2D1B	SH2 domain-containing protein 1B. (143 aa)
	STAT5B	Signal transducer and activator of transcription. (787 aa)
	PIK3R3	LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
	FYN	Tyrosine-protein kinase. (576 aa)
	SH2D4A	SH2 domain-containing protein 4A. (453 aa)
	SH2B3	SH2B adapter protein 3. (368 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
	JAK1	Tyrosine-protein kinase. (1153 aa)
	GRB2	Growth factor receptor-bound protein 2. (217 aa)
	GRB10	Growth factor receptor-bound protein 10. (586 aa)
	SH2B1	SH2B adapter protein 1 isoform X1. (757 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL2	CRKL	ENSUMAP00000028353	ENSUMAP00000004513	Tyrosine-protein kinase.	CRK like proto-oncogene, adaptor protein.	0.643
ABL2	GRB2	ENSUMAP00000028353	ENSUMAP00000011527	Tyrosine-protein kinase.	Growth factor receptor-bound protein 2.	0.616
BLK	GRAP2	ENSUMAP00000030139	ENSUMAP00000019603	Tyrosine-protein kinase.	GRB2 related adaptor protein 2.	0.441
BLK	GRB2	ENSUMAP00000030139	ENSUMAP00000011527	Tyrosine-protein kinase.	Growth factor receptor-bound protein 2.	0.498
BLK	SHC1	ENSUMAP00000030139	ENSUMAP00000027412	Tyrosine-protein kinase.	LOW QUALITY PROTEIN: SHC-transforming protein 1.	0.409
BMX	GRAP2	ENSUMAP00000007462	ENSUMAP00000019603	Tyrosine-protein kinase.	GRB2 related adaptor protein 2.	0.584
BMX	GRB10	ENSUMAP00000007462	ENSUMAP00000012526	Tyrosine-protein kinase.	Growth factor receptor-bound protein 10.	0.405
BMX	GRB2	ENSUMAP00000007462	ENSUMAP00000011527	Tyrosine-protein kinase.	Growth factor receptor-bound protein 2.	0.595
BMX	LYN	ENSUMAP00000007462	ENSUMAP00000013226	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.592
BMX	SH2D7	ENSUMAP00000007462	ENSUMAP00000014976	Tyrosine-protein kinase.	SH2 domain-containing protein 7 isoform X2.	0.560
BMX	VAV1	ENSUMAP00000007462	ENSUMAP00000017343	Tyrosine-protein kinase.	Vav guanine nucleotide exchange factor 1.	0.508
BMX	VAV3	ENSUMAP00000007462	ENSUMAP00000016936	Tyrosine-protein kinase.	Guanine nucleotide exchange factor VAV3.	0.508
BTK	CRKL	ENSUMAP00000016522	ENSUMAP00000004513	Tyrosine-protein kinase.	CRK like proto-oncogene, adaptor protein.	0.403
BTK	DAPP1	ENSUMAP00000016522	ENSUMAP00000006547	Tyrosine-protein kinase.	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide.	0.430
BTK	FYN	ENSUMAP00000016522	ENSUMAP00000035440	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.422
BTK	GRAP2	ENSUMAP00000016522	ENSUMAP00000019603	Tyrosine-protein kinase.	GRB2 related adaptor protein 2.	0.714
BTK	GRB2	ENSUMAP00000016522	ENSUMAP00000011527	Tyrosine-protein kinase.	Growth factor receptor-bound protein 2.	0.802
BTK	ITK	ENSUMAP00000016522	ENSUMAP00000003093	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.529
BTK	LYN	ENSUMAP00000016522	ENSUMAP00000013226	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.973
BTK	PIK3R1	ENSUMAP00000016522	ENSUMAP00000010701	Tyrosine-protein kinase.	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1.	0.938