41 items (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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co-expression

protein homology

Your Input:
	CASP10	Caspase-10 isoform X1; Belongs to the peptidase C14A family. (481 aa)
	TRADD	Tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2. (314 aa)
	TNFRSF11B	Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
	EDAR	Tumor necrosis factor receptor superfamily member EDAR isoform X2. (447 aa)
	CFLAR	CASP8 and FADD-like apoptosis regulator isoform X2; Belongs to the peptidase C14A family. (482 aa)
	CASP8	Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
	CASP9	Caspase-9 isoform X1; Belongs to the peptidase C14A family. (413 aa)
	BIRC7	Baculoviral IAP repeat-containing protein 7. (279 aa)
	CARD8	Caspase recruitment domain-containing protein 8 isoform X1. (435 aa)
	DEDD	Death effector domain-containing protein. (318 aa)
	IRAK4	Interleukin-1 receptor-associated kinase 4. (460 aa)
	NLRP9	NACHT, LRR and PYD domains-containing protein 9. (980 aa)
	NLRP13	NACHT, LRR and PYD domains-containing protein 13. (1024 aa)
	THOC1	THO complex subunit 1. (657 aa)
	RIPK1	Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
	IRAK2	Interleukin-1 receptor-associated kinase-like 2. (632 aa)
	NLRP3	NACHT, LRR and PYD domains-containing protein 3 isoform X1. (1024 aa)
	RIPK2	LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 2. (512 aa)
	PYCARD	Apoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
	EDARADD	ectodysplasin-A receptor-associated adapter protein. (208 aa)
	FAS	Tumor necrosis factor receptor superfamily member 6 isoform X1. (351 aa)
	UNC5CL	LOW QUALITY PROTEIN: UNC5C-like protein. (492 aa)
	IFIH1	Interferon-induced helicase C domain-containing protein 1 isoform X1. (1016 aa)
	CASP2	Caspase-2 isoform X1; Belongs to the peptidase C14A family. (452 aa)
	BIRC2	Baculoviral IAP repeat-containing protein 2. (619 aa)
	LOC103662441	Caspase-12-like isoform X1; Belongs to the peptidase C14A family. (493 aa)
	LOC103662442	Caspase-13-like isoform X1; Belongs to the peptidase C14A family. (486 aa)
	CARD6	Caspase recruitment domain-containing protein 6. (1079 aa)
	DDX58	Probable ATP-dependent RNA helicase DDX58 isoform X1. (928 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1252 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
	UNC5C	Netrin receptor UNC5C isoform X2. (950 aa)
	LOC103674871	Death domain-containing membrane protein NRADD-like. (248 aa)
	CRADD	CASP2 and RIPK1 domain containing adaptor with death domain. (250 aa)
	BCL10	BCL10 immune signaling adaptor. (234 aa)
	MNDA	Myeloid cell nuclear differentiation antigen-like. (434 aa)
	LOC103672063	Myeloid cell nuclear differentiation antigen-like protein isoform X1. (726 aa)
	MEFV	Pyrin isoform X1. (893 aa)
	DTHD1	Death domain-containing protein 1. (905 aa)
	TTC3	LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase TTC3. (1999 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BIRC2	ENSUMAP00000007241	ENSUMAP00000012471	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat-containing protein 2.	0.661
APAF1	BIRC7	ENSUMAP00000007241	ENSUMAP00000030854	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat-containing protein 7.	0.656
APAF1	CARD8	ENSUMAP00000007241	ENSUMAP00000033092	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase recruitment domain-containing protein 8 isoform X1.	0.731
APAF1	CASP10	ENSUMAP00000007241	ENSUMAP00000029779	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-10 isoform X1; Belongs to the peptidase C14A family.	0.780
APAF1	CASP2	ENSUMAP00000007241	ENSUMAP00000016144	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-2 isoform X1; Belongs to the peptidase C14A family.	0.879
APAF1	CASP8	ENSUMAP00000007241	ENSUMAP00000029788	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-8 isoform X1; Belongs to the peptidase C14A family.	0.926
APAF1	CASP9	ENSUMAP00000007241	ENSUMAP00000030022	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-9 isoform X1; Belongs to the peptidase C14A family.	0.999
APAF1	CFLAR	ENSUMAP00000007241	ENSUMAP00000029777	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	CASP8 and FADD-like apoptosis regulator isoform X2; Belongs to the peptidase C14A family.	0.735
APAF1	FAS	ENSUMAP00000007241	ENSUMAP00000016893	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Tumor necrosis factor receptor superfamily member 6 isoform X1.	0.512
APAF1	LOC103662441	ENSUMAP00000007241	ENSUMAP00000012048	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-12-like isoform X1; Belongs to the peptidase C14A family.	0.731
APAF1	LOC103662442	ENSUMAP00000007241	ENSUMAP00000012038	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-13-like isoform X1; Belongs to the peptidase C14A family.	0.795
APAF1	TRADD	ENSUMAP00000007241	ENSUMAP00000027876	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2.	0.455
BCL10	BIRC2	ENSUMAP00000002851	ENSUMAP00000012471	BCL10 immune signaling adaptor.	Baculoviral IAP repeat-containing protein 2.	0.499
BCL10	CASP10	ENSUMAP00000002851	ENSUMAP00000029779	BCL10 immune signaling adaptor.	Caspase-10 isoform X1; Belongs to the peptidase C14A family.	0.403
BCL10	CASP8	ENSUMAP00000002851	ENSUMAP00000029788	BCL10 immune signaling adaptor.	Caspase-8 isoform X1; Belongs to the peptidase C14A family.	0.937
BCL10	LOC103662442	ENSUMAP00000002851	ENSUMAP00000012038	BCL10 immune signaling adaptor.	Caspase-13-like isoform X1; Belongs to the peptidase C14A family.	0.478
BCL10	NFKB1	ENSUMAP00000002851	ENSUMAP00000006647	BCL10 immune signaling adaptor.	Nuclear factor NF-kappa-B p105 subunit isoform X1.	0.640
BCL10	RIPK2	ENSUMAP00000002851	ENSUMAP00000020907	BCL10 immune signaling adaptor.	LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 2.	0.577
BIRC2	APAF1	ENSUMAP00000012471	ENSUMAP00000007241	Baculoviral IAP repeat-containing protein 2.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.661
BIRC2	BCL10	ENSUMAP00000012471	ENSUMAP00000002851	Baculoviral IAP repeat-containing protein 2.	BCL10 immune signaling adaptor.	0.499