(11 nodes) Phosphatidylinositol 3/4-kinase, conserved site network (Ursus maritimus)

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Your Input:
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3061 aa)
	PRKDC	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4135 aa)
	ATR	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2637 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
	PIK3CG	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1090 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2531 aa)
	PIK3C2A	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Belongs to the PI3/PI4-kinase family. (1688 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (888 aa)
	PIK3C2G	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1; Belongs to the PI3/PI4-kinase family. (1486 aa)
	PI4KA	Phosphatidylinositol 4-kinase alpha isoform X1; Belongs to the PI3/PI4-kinase family. (2044 aa)
	SMG1	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3654 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	ATR	ENSUMAP00000011132	ENSUMAP00000018536	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	0.998
ATM	MTOR	ENSUMAP00000011132	ENSUMAP00000032412	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.569
ATM	PRKDC	ENSUMAP00000011132	ENSUMAP00000012568	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.792
ATM	SMG1	ENSUMAP00000011132	ENSUMAP00000009878	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family.	0.603
ATR	ATM	ENSUMAP00000018536	ENSUMAP00000011132	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.998
MTOR	ATM	ENSUMAP00000032412	ENSUMAP00000011132	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.569
MTOR	PIK3CB	ENSUMAP00000032412	ENSUMAP00000020299	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.929
MTOR	PIK3CG	ENSUMAP00000032412	ENSUMAP00000025080	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family.	0.424
PI4KA	PIK3C2A	ENSUMAP00000004462	ENSUMAP00000032547	Phosphatidylinositol 4-kinase alpha isoform X1; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Belongs to the PI3/PI4-kinase family.	0.912
PI4KA	PIK3C2G	ENSUMAP00000004462	ENSUMAP00000003624	Phosphatidylinositol 4-kinase alpha isoform X1; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1; Belongs to the PI3/PI4-kinase family.	0.902
PI4KA	PIK3C3	ENSUMAP00000004462	ENSUMAP00000002536	Phosphatidylinositol 4-kinase alpha isoform X1; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.919
PIK3C2A	PI4KA	ENSUMAP00000032547	ENSUMAP00000004462	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4-kinase alpha isoform X1; Belongs to the PI3/PI4-kinase family.	0.912
PIK3C2A	PIK3C2G	ENSUMAP00000032547	ENSUMAP00000003624	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1; Belongs to the PI3/PI4-kinase family.	0.993
PIK3C2A	PIK3C3	ENSUMAP00000032547	ENSUMAP00000002536	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.532
PIK3C2A	PIK3CG	ENSUMAP00000032547	ENSUMAP00000025080	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family.	0.527
PIK3C2G	PI4KA	ENSUMAP00000003624	ENSUMAP00000004462	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4-kinase alpha isoform X1; Belongs to the PI3/PI4-kinase family.	0.902
PIK3C2G	PIK3C2A	ENSUMAP00000003624	ENSUMAP00000032547	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Belongs to the PI3/PI4-kinase family.	0.993
PIK3C2G	PIK3C3	ENSUMAP00000003624	ENSUMAP00000002536	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.518
PIK3C3	PI4KA	ENSUMAP00000002536	ENSUMAP00000004462	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Phosphatidylinositol 4-kinase alpha isoform X1; Belongs to the PI3/PI4-kinase family.	0.919
PIK3C3	PIK3C2A	ENSUMAP00000002536	ENSUMAP00000032547	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Belongs to the PI3/PI4-kinase family.	0.532