(28 nodes) Translesion synthesis by POLK network (Ursus maritimus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	ENSUMAP00000001832	annotation not available (79 aa)
	RFC4	Replication factor C subunit 4. (363 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (301 aa)
	ENSUMAP00000006417	annotation not available (140 aa)
	POLK	DNA polymerase kappa. (870 aa)
	ENSUMAP00000009735	annotation not available (166 aa)
	REV1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1252 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	KXD1	kxDL motif-containing protein 1. (200 aa)
	RPA2	Replication protein A 32 kDa subunit. (321 aa)
	RFC5	Replication factor C subunit 5. (255 aa)
	RFC2	Replication factor C subunit 2. (325 aa)
	ENSUMAP00000019418	annotation not available (129 aa)
	ATAD5	ATPase family AAA domain-containing protein 5. (1847 aa)
	RPS27A	ubiquitin-40S ribosomal protein S27a. (184 aa)
	RCBTB2	RCC1 and BTB domain-containing protein 2 isoform X1. (573 aa)
	RCBTB1	RCC1 and BTB domain-containing protein 1. (497 aa)
	RPA3	Replication protein A 14 kDa subunit. (268 aa)
	MEIOB	Meiosis-specific with OB domain-containing protein. (471 aa)
	ENSUMAP00000030728	annotation not available (140 aa)
	ENSUMAP00000030752	Polyubiquitin-like. (77 aa)
	MAD2L2	Mitotic spindle assembly checkpoint protein MAD2B. (308 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	ENSUMAP00000034969	annotation not available (120 aa)
	REV3L	DNA polymerase zeta catalytic subunit. (3131 aa)
	RFC1	Replication factor C subunit 1. (1129 aa)
	UBC	LOW QUALITY PROTEIN: polyubiquitin-B. (305 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	ENSUMAP00000001832	ENSUMAP00000020850	ENSUMAP00000001832	ATPase family AAA domain-containing protein 5.	annotation not available	0.434
ATAD5	ENSUMAP00000019418	ENSUMAP00000020850	ENSUMAP00000019418	ATPase family AAA domain-containing protein 5.	annotation not available	0.916
ATAD5	ENSUMAP00000030728	ENSUMAP00000020850	ENSUMAP00000030728	ATPase family AAA domain-containing protein 5.	annotation not available	0.402
ATAD5	MAD2L2	ENSUMAP00000020850	ENSUMAP00000031711	ATPase family AAA domain-containing protein 5.	Mitotic spindle assembly checkpoint protein MAD2B.	0.549
ATAD5	MEIOB	ENSUMAP00000020850	ENSUMAP00000030590	ATPase family AAA domain-containing protein 5.	Meiosis-specific with OB domain-containing protein.	0.644
ATAD5	PCNA	ENSUMAP00000020850	ENSUMAP00000005923	ATPase family AAA domain-containing protein 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.944
ATAD5	POLK	ENSUMAP00000020850	ENSUMAP00000009553	ATPase family AAA domain-containing protein 5.	DNA polymerase kappa.	0.556
ATAD5	REV1	ENSUMAP00000020850	ENSUMAP00000011127	ATPase family AAA domain-containing protein 5.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.588
ATAD5	REV3L	ENSUMAP00000020850	ENSUMAP00000035444	ATPase family AAA domain-containing protein 5.	DNA polymerase zeta catalytic subunit.	0.677
ATAD5	RFC1	ENSUMAP00000020850	ENSUMAP00000000784	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 1.	0.402
ATAD5	RFC2	ENSUMAP00000020850	ENSUMAP00000019415	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 2.	0.916
ATAD5	RFC3	ENSUMAP00000020850	ENSUMAP00000032889	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 3.	0.964
ATAD5	RFC4	ENSUMAP00000020850	ENSUMAP00000005324	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 4.	0.990
ATAD5	RFC5	ENSUMAP00000020850	ENSUMAP00000015766	ATPase family AAA domain-containing protein 5.	Replication factor C subunit 5.	0.955
ATAD5	RPA1	ENSUMAP00000020850	ENSUMAP00000012546	ATPase family AAA domain-containing protein 5.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.644
ATAD5	RPA2	ENSUMAP00000020850	ENSUMAP00000015281	ATPase family AAA domain-containing protein 5.	Replication protein A 32 kDa subunit.	0.504
ATAD5	RPA3	ENSUMAP00000020850	ENSUMAP00000029766	ATPase family AAA domain-containing protein 5.	Replication protein A 14 kDa subunit.	0.434
ATAD5	RPS27A	ENSUMAP00000020850	ENSUMAP00000023029	ATPase family AAA domain-containing protein 5.	ubiquitin-40S ribosomal protein S27a.	0.475
ENSUMAP00000001832	ATAD5	ENSUMAP00000001832	ENSUMAP00000020850	annotation not available	ATPase family AAA domain-containing protein 5.	0.434
ENSUMAP00000001832	ENSUMAP00000019418	ENSUMAP00000001832	ENSUMAP00000019418	annotation not available	annotation not available	0.643