STRINGSTRING
IKBKB IKBKB UBC UBC RBCK1 RBCK1 TAX1BP1 TAX1BP1 TAB2 TAB2 ULK1 ULK1 ADAM17 ADAM17 OTUD7B OTUD7B TRAF1 TRAF1 IKBKE IKBKE ENSUMAP00000006417 ENSUMAP00000006417 ENSUMAP00000006878 ENSUMAP00000006878 CYLD CYLD UBE2D1 UBE2D1 ENSUMAP00000008777 ENSUMAP00000008777 ULK2 ULK2 SPPL2B SPPL2B FADD FADD ENSUMAP00000009501 ENSUMAP00000009501 ENSUMAP00000009735 ENSUMAP00000009735 TNFRSF1A TNFRSF1A UBA52 UBA52 KXD1 KXD1 BAG4 BAG4 BIRC2 BIRC2 BIRC3 BIRC3 RACK1 RACK1 NSMAF NSMAF ENSUMAP00000013329 ENSUMAP00000013329 MAP3K7 MAP3K7 ENSUMAP00000017050 ENSUMAP00000017050 OPTN OPTN LOC103679172 LOC103679172 MADD MADD TAB1 TAB1 TAB3 TAB3 TNF TNF MAP3K20 MAP3K20 SPPL2C SPPL2C UBE2D2 UBE2D2 LOC103682439 LOC103682439 RPS27A RPS27A SPPL2A SPPL2A TMEM198 TMEM198 RIPK1 RIPK1 SMPD3 SMPD3 IKBKG IKBKG WDR31 WDR31 CLIP4 CLIP4 TRADD TRADD TBK1 TBK1 CLIP3 CLIP3 SHARPIN SHARPIN STUB1 STUB1 CFLAR CFLAR CASP8 CASP8 OTULIN OTULIN OTULINL OTULINL ENSUMAP00000030752 ENSUMAP00000030752 BIRC7 BIRC7 RNF31 RNF31 CHUK CHUK USP4-2 USP4-2 USP4 USP4 NFATC4 NFATC4 TRAF2 TRAF2 USP2 USP2 TNFAIP3 TNFAIP3 USP21 USP21 SPATA2 SPATA2 XIAP XIAP ENSUMAP00000034969 ENSUMAP00000034969 MAPKAPK2 MAPKAPK2 SMPD2 SMPD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
UBCLOW QUALITY PROTEIN: polyubiquitin-B. (305 aa)
RBCK1ranBP-type and C3HC4-type zinc finger-containing protein 1. (521 aa)
TAX1BP1Tax1-binding protein 1 isoform X2. (757 aa)
TAB2LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (670 aa)
ULK1Serine/threonine-protein kinase ULK1. (835 aa)
ADAM17Disintegrin and metalloproteinase domain-containing protein 17. (823 aa)
OTUD7BOTU domain-containing protein 7B isoform X1. (844 aa)
TRAF1TNF receptor-associated factor. (408 aa)
IKBKELOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit epsilon. (692 aa)
ENSUMAP00000006417annotation not available (140 aa)
ENSUMAP00000006878annotation not available (83 aa)
CYLDLOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family. (948 aa)
UBE2D1Ubiquitin-conjugating enzyme E2 D1 isoform X2; Belongs to the ubiquitin-conjugating enzyme family. (109 aa)
ENSUMAP00000008777annotation not available (79 aa)
ULK2Serine/threonine-protein kinase ULK2. (981 aa)
SPPL2BSignal peptide peptidase-like 2B. (558 aa)
FADDFAS-associated death domain protein. (192 aa)
ENSUMAP00000009501annotation not available (97 aa)
ENSUMAP00000009735annotation not available (166 aa)
TNFRSF1ALOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A. (507 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
KXD1kxDL motif-containing protein 1. (200 aa)
BAG4BAG family molecular chaperone regulator 4 isoform X1. (457 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (619 aa)
BIRC3Baculoviral IAP repeat-containing protein 3-like. (516 aa)
RACK1Guanine nucleotide-binding protein subunit beta-2-like 1. (374 aa)
NSMAFProtein FAN isoform X1. (846 aa)
ENSUMAP00000013329annotation not available (67 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ENSUMAP00000017050annotation not available (80 aa)
OPTNLOW QUALITY PROTEIN: optineurin. (490 aa)
LOC103679172LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 D3-like. (139 aa)
MADDMAP kinase-activating death domain protein isoform X1. (1650 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (498 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. (664 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase MLT isoform X1. (456 aa)
SPPL2CSignal peptide peptidase-like 2C. (123 aa)
UBE2D2Ubiquitin-conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (118 aa)
LOC103682439Transmembrane protein 198-like isoform X1. (119 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (184 aa)
SPPL2ASignal peptide peptidase-like 2A. (531 aa)
TMEM198LOW QUALITY PROTEIN: transmembrane protein 198. (327 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (658 aa)
IKBKGNF-kappa-B essential modulator. (291 aa)
WDR31WD repeat-containing protein 31. (365 aa)
CLIP4CAP-Gly domain-containing linker protein 4 isoform X1. (681 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2. (314 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
CLIP3CAP-Gly domain-containing linker protein 3. (546 aa)
SHARPINSharpin. (414 aa)
STUB1E3 ubiquitin-protein ligase CHIP. (298 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform X2; Belongs to the peptidase C14A family. (482 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
OTULINUbiquitin thioesterase otulin. (317 aa)
OTULINLOTU deubiquitinase with linear linkage specificity like. (327 aa)
ENSUMAP00000030752Polyubiquitin-like. (77 aa)
BIRC7Baculoviral IAP repeat-containing protein 7. (279 aa)
RNF31E3 ubiquitin-protein ligase RNF31 isoform X1. (1080 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (680 aa)
USP4-2Ubiquitin carboxyl-terminal hydrolase 4/11. (459 aa)
USP4Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (567 aa)
NFATC4LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 4. (787 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (494 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (558 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (714 aa)
USP21Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (565 aa)
SPATA2Spermatogenesis-associated protein 2. (453 aa)
XIAPE3 ubiquitin-protein ligase XIAP. (497 aa)
ENSUMAP00000034969annotation not available (120 aa)
MAPKAPK2MAP kinase-activated protein kinase 2. (349 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (416 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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