STRINGSTRING
DUSP3 DUSP3 IKBKB IKBKB MAPKAPK2 MAPKAPK2 ENSUMAP00000034969 ENSUMAP00000034969 S100B S100B MAPK10 MAPK10 NLRP13 NLRP13 NLRP9 NLRP9 MAPK9 MAPK9 LOC103669669-2 LOC103669669-2 NFKB2 NFKB2 TRAF2 TRAF2 NKIRAS2 NKIRAS2 KHNYN KHNYN RIPK3 RIPK3 CHUK CHUK CREB1 CREB1 BIRC7 BIRC7 ENSUMAP00000030752 ENSUMAP00000030752 MAPKAPK3 MAPKAPK3 CASP8 CASP8 DUSP7 DUSP7 MAP2K4 MAP2K4 TRAF5 TRAF5 S100A12 S100A12 LOC103659414 LOC103659414 LOC103659449 LOC103659449 TBK1 TBK1 FOSL2 FOSL2 USP14 USP14 TONSL TONSL LRRC14 LRRC14 IKBKG IKBKG NFKBIB NFKBIB LY96 LY96 RIPK1 RIPK1 PPP4R1 PPP4R1 IRAK2 IRAK2 NKIRAS1 NKIRAS1 PPP2CA PPP2CA LRRC71 LRRC71 TRAF6 TRAF6 HMGB1 HMGB1 RPS27A RPS27A LRRC45 LRRC45 UBE2D2 UBE2D2 MAPK8 MAPK8 ATF2 ATF2 MAP3K20 MAP3K20 RIPK2 RIPK2 ENSUMAP00000020575 ENSUMAP00000020575 TAB3 TAB3 APP APP TAB1 TAB1 LOC103679172 LOC103679172 CD14 CD14 ENSUMAP00000017563 ENSUMAP00000017563 RPS6KA1 RPS6KA1 MAP3K7 MAP3K7 SARM1 SARM1 TRAF4 TRAF4 RPS6KA2 RPS6KA2 LOC103668179 LOC103668179 USP18 USP18 NFKBIA NFKBIA MAPK3 MAPK3 RPS6KA3 RPS6KA3 RELA RELA ATF7 ATF7 PPP2R1A PPP2R1A MAPK14 MAPK14 AGER AGER BIRC3 BIRC3 BIRC2 BIRC2 PPP2R5D PPP2R5D FNBP4 FNBP4 KXD1 KXD1 UBA52 UBA52 TICAM1 TICAM1 TANK TANK ATF1 ATF1 FOS FOS MAP2K6 MAP2K6 LRRC74A LRRC74A ENSUMAP00000009735 ENSUMAP00000009735 VRK3 VRK3 PPP2CB PPP2CB FADD FADD PPP2R1B PPP2R1B N4BP1 N4BP1 TNIP2 TNIP2 UBE2D1 UBE2D1 RPS6KA5 RPS6KA5 MAPK7 MAPK7 ENSUMAP00000008134 ENSUMAP00000008134 TRAF3 TRAF3 NOD2 NOD2 NLRP6 NLRP6 ENSUMAP00000006650 ENSUMAP00000006650 NFKB1 NFKB1 ENSUMAP00000006417 ENSUMAP00000006417 MAP2K3 MAP2K3 RELCH RELCH PPP4R4 PPP4R4 LOC103669296 LOC103669296 TLR4 TLR4 IKBKE IKBKE MAPK1 MAPK1 UBE2N UBE2N RPS6KA4 RPS6KA4 TAB2 TAB2 IRF3 IRF3 LOC103670942 LOC103670942 LOC103682087 LOC103682087 DUSP6 DUSP6 LRRC34 LRRC34 ALPK1 ALPK1 ENSUMAP00000002447 ENSUMAP00000002447 TIFA TIFA NOD1 NOD1 CREB5 CREB5 UBC UBC NLRC5 NLRC5 NLRX1 NLRX1 LOC103679399 LOC103679399
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (173 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
MAPKAPK2MAP kinase-activated protein kinase 2. (349 aa)
ENSUMAP00000034969annotation not available (120 aa)
S100BProtein S100; Belongs to the S-100 family. (104 aa)
MAPK10Mitogen-activated protein kinase. (460 aa)
NLRP13NACHT, LRR and PYD domains-containing protein 13. (1024 aa)
NLRP9NACHT, LRR and PYD domains-containing protein 9. (980 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
LOC103669669-2Ubiquitin-conjugating enzyme E2 variant 1 isoform X2. (147 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit. (925 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (494 aa)
NKIRAS2NF-kappa-B inhibitor-interacting Ras-like protein 2. (191 aa)
KHNYNKH and NYN domain containing. (668 aa)
RIPK3Receptor-interacting serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. (487 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (680 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
BIRC7Baculoviral IAP repeat-containing protein 7. (279 aa)
ENSUMAP00000030752Polyubiquitin-like. (77 aa)
MAPKAPK3MAP kinase-activated protein kinase 3 isoform X1; Belongs to the protein kinase superfamily. (384 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
DUSP7Dual specificity protein phosphatase 7. (253 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (411 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (582 aa)
S100A12S100 calcium binding protein A12; Belongs to the S-100 family. (92 aa)
LOC103659414Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (117 aa)
LOC103659449Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (124 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (301 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (501 aa)
TONSLTonsoku-like protein. (1369 aa)
LRRC14Leucine-rich repeat-containing protein 14 isoform X2. (219 aa)
IKBKGNF-kappa-B essential modulator. (291 aa)
NFKBIBLOW QUALITY PROTEIN: NF-kappa-B inhibitor beta. (360 aa)
LY96Lymphocyte antigen 96. (160 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1. (936 aa)
IRAK2Interleukin-1 receptor-associated kinase-like 2. (632 aa)
NKIRAS1NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1. (192 aa)
PPP2CAProtein phosphatase 2 catalytic subunit alpha. (307 aa)
LRRC71Leucine-rich repeat-containing protein 71. (272 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
HMGB1High mobility group protein B1. (215 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (184 aa)
LRRC45Leucine-rich repeat-containing protein 45. (619 aa)
UBE2D2Ubiquitin-conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (118 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (482 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase MLT isoform X1. (456 aa)
RIPK2LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 2. (512 aa)
ENSUMAP00000020575annotation not available (177 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. (664 aa)
APPGamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (747 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (498 aa)
LOC103679172LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 D3-like. (139 aa)
CD14Monocyte differentiation antigen CD14 isoform X2. (439 aa)
ENSUMAP00000017563annotation not available (152 aa)
RPS6KA1Ribosomal protein S6 kinase. (719 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
SARM1Sterile alpha and TIR motif-containing protein 1. (285 aa)
TRAF4TNF receptor-associated factor. (435 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
LOC103668179LOW QUALITY PROTEIN: high mobility group protein B1-like. (200 aa)
USP18Ubl carboxyl-terminal hydrolase 18 isoform X1; Belongs to the peptidase C19 family. (339 aa)
NFKBIANF-kappa-B inhibitor alpha. (253 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
RPS6KA3Ribosomal protein S6 kinase. (718 aa)
RELATranscription factor p65. (585 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (483 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
MAPK14Mitogen-activated protein kinase. (362 aa)
AGERAdvanced glycosylation end product-specific receptor. (311 aa)
BIRC3Baculoviral IAP repeat-containing protein 3-like. (516 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (619 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (600 aa)
FNBP4Formin-binding protein 4. (924 aa)
KXD1kxDL motif-containing protein 1. (200 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
TICAM1TIR domain-containing adapter molecule 1. (647 aa)
TANKTRAF family member-associated NF-kappa-B activator isoform X2. (426 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1. (279 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
LRRC74ALeucine-rich repeat-containing protein 74. (214 aa)
ENSUMAP00000009735annotation not available (166 aa)
VRK3Inactive serine/threonine-protein kinase VRK3 isoform X1. (509 aa)
PPP2CBSerine/threonine-protein phosphatase. (290 aa)
FADDFAS-associated death domain protein. (192 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (650 aa)
N4BP1NEDD4-binding protein 1 isoform X1. (810 aa)
TNIP2TNFAIP3 interacting protein 2. (329 aa)
UBE2D1Ubiquitin-conjugating enzyme E2 D1 isoform X2; Belongs to the ubiquitin-conjugating enzyme family. (109 aa)
RPS6KA5Ribosomal protein S6 kinase. (853 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (264 aa)
ENSUMAP00000008134annotation not available (95 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (817 aa)
NLRP6NACHT, LRR and PYD domains-containing protein 6. (795 aa)
ENSUMAP00000006650annotation not available (149 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
ENSUMAP00000006417annotation not available (140 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
RELCHlisH domain and HEAT repeat-containing protein KIAA1468 homolog. (1223 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4. (875 aa)
LOC103669296Leucine-rich repeat-containing protein-like. (138 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
IKBKELOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit epsilon. (692 aa)
MAPK1Mitogen-activated protein kinase. (363 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (195 aa)
RPS6KA4Non-specific serine/threonine protein kinase. (558 aa)
TAB2LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (670 aa)
IRF3Interferon regulatory factor 3 isoform X2. (421 aa)
LOC103670942Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like. (933 aa)
LOC103682087Tyrosine-protein phosphatase non-receptor type 11-like. (218 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (316 aa)
LRRC34Leucine-rich repeat-containing protein 34 isoform X1. (402 aa)
ALPK1Alpha-protein kinase 1. (920 aa)
ENSUMAP00000002447annotation not available (165 aa)
TIFATRAF-interacting protein with FHA domain-containing protein A. (168 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (263 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
UBCLOW QUALITY PROTEIN: polyubiquitin-B. (305 aa)
NLRC5Protein NLRC5. (1728 aa)
NLRX1NLR family member X1. (1463 aa)
LOC103679399Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
Server load: low (16%) [HD]