19 items (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	MB	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
	EDN3	Endothelin-3. (192 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1252 aa)
	EGLN1	Egl nine homolog 1. (176 aa)
	BNIP3	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (236 aa)
	EPO	LOW QUALITY PROTEIN: erythropoietin. (192 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (565 aa)
	HIF1A	Hypoxia-inducible factor 1-alpha isoform X2. (823 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	SIRT7	NAD-dependent protein deacetylase sirtuin-7. (251 aa)
	EDN2	Endothelin-2. (257 aa)
	CSRP2	Cysteine and glycine-rich protein 2. (193 aa)
	OGT	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1. (1046 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha isoform X1. (468 aa)
	LMCD1	LIM and cysteine-rich domains protein 1. (363 aa)
	ATF3	Cyclic AMP-dependent transcription factor ATF-3. (181 aa)
	EDN1	Endothelin-1. (202 aa)
	PLXNA4	plexin-A4 isoform X1. (1884 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	ATF3	ENSUMAP00000007241	ENSUMAP00000024813	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cyclic AMP-dependent transcription factor ATF-3.	0.425
APAF1	BNIP3	ENSUMAP00000007241	ENSUMAP00000013092	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3.	0.473
APAF1	CSRP2	ENSUMAP00000007241	ENSUMAP00000029707	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cysteine and glycine-rich protein 2.	0.402
APAF1	EDN2	ENSUMAP00000007241	ENSUMAP00000033843	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Endothelin-2.	0.400
APAF1	EDN3	ENSUMAP00000007241	ENSUMAP00000001011	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Endothelin-3.	0.400
APAF1	EDNRA	ENSUMAP00000007241	ENSUMAP00000021577	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.400
APAF1	LMCD1	ENSUMAP00000007241	ENSUMAP00000026536	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	LIM and cysteine-rich domains protein 1.	0.419
APAF1	MDM2	ENSUMAP00000007241	ENSUMAP00000028570	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.469
APAF1	PLXNA4	ENSUMAP00000007241	ENSUMAP00000024021	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	plexin-A4 isoform X1.	0.400
APAF1	PTEN	ENSUMAP00000007241	ENSUMAP00000016792	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.460
APAF1	SIRT7	ENSUMAP00000007241	ENSUMAP00000022435	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	NAD-dependent protein deacetylase sirtuin-7.	0.408
ATF3	APAF1	ENSUMAP00000024813	ENSUMAP00000007241	Cyclic AMP-dependent transcription factor ATF-3.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.425
ATF3	BNIP3	ENSUMAP00000024813	ENSUMAP00000013092	Cyclic AMP-dependent transcription factor ATF-3.	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3.	0.407
ATF3	CSRP2	ENSUMAP00000024813	ENSUMAP00000029707	Cyclic AMP-dependent transcription factor ATF-3.	Cysteine and glycine-rich protein 2.	0.490
ATF3	EDN2	ENSUMAP00000024813	ENSUMAP00000033843	Cyclic AMP-dependent transcription factor ATF-3.	Endothelin-2.	0.406
ATF3	EDN3	ENSUMAP00000024813	ENSUMAP00000001011	Cyclic AMP-dependent transcription factor ATF-3.	Endothelin-3.	0.406
ATF3	EDNRA	ENSUMAP00000024813	ENSUMAP00000021577	Cyclic AMP-dependent transcription factor ATF-3.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.406
ATF3	EPO	ENSUMAP00000024813	ENSUMAP00000014808	Cyclic AMP-dependent transcription factor ATF-3.	LOW QUALITY PROTEIN: erythropoietin.	0.404
ATF3	LMCD1	ENSUMAP00000024813	ENSUMAP00000026536	Cyclic AMP-dependent transcription factor ATF-3.	LIM and cysteine-rich domains protein 1.	0.507
ATF3	MDM2	ENSUMAP00000024813	ENSUMAP00000028570	Cyclic AMP-dependent transcription factor ATF-3.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.560