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DRD5 DRD5 EDN3 EDN3 ATP1A4 ATP1A4 CNGA4 CNGA4 ATP1A2 ATP1A2 LOC103657111 LOC103657111 NPY NPY CALML6 CALML6 ADORA2A ADORA2A CACNA1S CACNA1S CREB5 CREB5 HTR1F HTR1F LIPE LIPE CNGA1 CNGA1 LOC103670936 LOC103670936 ATP2B1 ATP2B1 GRIN2B GRIN2B ADCYAP1R1 ADCYAP1R1 CREBBP CREBBP RRAS RRAS ADCY9 ADCY9 PRKACB PRKACB BAD BAD ROCK2 ROCK2 PLN PLN CFTR CFTR GRIA1 GRIA1 CAMK2D CAMK2D MAPK1 MAPK1 PDE3A PDE3A GRIN2A GRIN2A DRD2 DRD2 SST SST MYL9 MYL9 CAMK2A CAMK2A PLCE1 PLCE1 PPP1R12A PPP1R12A PRKACA PRKACA F2R F2R HCAR1 HCAR1 HCAR2 HCAR2 NFKB1 NFKB1 ADRB2 ADRB2 ATP2B4 ATP2B4 GLP1R GLP1R ORAI1 ORAI1 CALM1 CALM1 TSHR TSHR ATP2A2 ATP2A2 CREB3 CREB3 PPP1CC PPP1CC PDE4B PDE4B ATP2A3 ATP2A3 FOS FOS SSTR2 SSTR2 PIK3CA PIK3CA PIK3R1 PIK3R1 GHSR GHSR SSTR1 SSTR1 PDE4D PDE4D GRIA4 GRIA4 ATP2A1 ATP2A1 PDE4C PDE4C PIK3R2 PIK3R2 PTCH1 PTCH1 CAMK2B-2 CAMK2B-2 CNGA2 CNGA2 GLI3 GLI3 PLD1 PLD1 ACOX3 ACOX3 HTR1E HTR1E CGA CGA RELA RELA ACOX1 ACOX1 MAPK3 MAPK3 NFKBIA NFKBIA AFDN AFDN ATP1A1 ATP1A1 PAK1 PAK1 TSHB TSHB CNGA3 CNGA3 PDE10A PDE10A CACNA1C CACNA1C ARAP3 ARAP3 GPR119 GPR119 AKT3 AKT3 SLC9A1 SLC9A1 CALML4 CALML4 SUCNR1 SUCNR1 GCG GCG CALML5 CALML5 MAP2K1 MAP2K1 VAV3 VAV3 GABBR2 GABBR2 PPP1CA PPP1CA CAMK2G CAMK2G VAV1 VAV1 RYR2 RYR2 GRIN3A GRIN3A HTR1D HTR1D GNAI3 GNAI3 VIPR2 VIPR2 FSHR FSHR ATP1B3 ATP1B3 RAP1A RAP1A GNAI1 GNAI1 LOC103659828 LOC103659828 PLD2-2 PLD2-2 PTGER2 PTGER2 CHRM1 CHRM1 ENSUMAP00000020007 ENSUMAP00000020007 PIK3CB PIK3CB BRAF BRAF CNGB3 CNGB3 RAPGEF4 RAPGEF4 CREB3L1 CREB3L1 HHIP HHIP HTR1B HTR1B MAPK8 MAPK8 EDNRA EDNRA CREB3L2 CREB3L2 CAMK4 CAMK4 ADCY10 ADCY10 TIAM1 TIAM1 ATP1B2 ATP1B2 RRAS2 RRAS2 PDE3B PDE3B PPP1R1B PPP1R1B ATP1B1 ATP1B1 RAF1 RAF1 EDN1 EDN1 LOC103682502 LOC103682502 FFAR2 FFAR2 ATP2B2 ATP2B2 GHRL GHRL GABBR1 GABBR1 PPARA PPARA AKT2 AKT2 FSHB FSHB ADCYAP1 ADCYAP1 ROCK1 ROCK1 NPY1R NPY1R GLI1 GLI1 PPP1CB PPP1CB CACNA1D CACNA1D CREB3L4 CREB3L4 RAP1B RAP1B ADCY2 ADCY2 CNGB1 CNGB1 EP300 EP300 ADCY8 ADCY8 ADCY3 ADCY3 CREB1 CREB1 NPPA NPPA RHOA RHOA ADCY4 ADCY4 GRIA3 GRIA3 PIK3R3 PIK3R3 VIP VIP DRD1 DRD1 MAPK9 MAPK9 TNNI3 TNNI3 AKT1 AKT1 MC2R MC2R MAPK10 MAPK10 PDE4A PDE4A ADCY5 ADCY5 ABCC4 ABCC4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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DRD5D(1B) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (442 aa)
EDN3Endothelin-3. (192 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1050 aa)
CNGA4LOW QUALITY PROTEIN: cyclic nucleotide-gated cation channel alpha-4. (554 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1041 aa)
LOC103657111Lutropin subunit beta. (140 aa)
NPYPro-neuropeptide Y. (97 aa)
CALML6Calmodulin-like protein 6. (180 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (409 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1823 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa)
HTR1F5-hydroxytryptamine receptor 1F. (366 aa)
LIPELOW QUALITY PROTEIN: hormone-sensitive lipase. (1264 aa)
CNGA1cGMP-gated cation channel alpha-1. (676 aa)
LOC103670936Neuroendocrine secretory protein 55. (247 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
ADCYAP1R1Pituitary adenylate cyclase-activating polypeptide type I receptor; Belongs to the G-protein coupled receptor 2 family. (497 aa)
CREBBPCREB-binding protein. (1954 aa)
RRASRas-related protein R-Ras. (195 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
BADBcl2-associated agonist of cell death. (168 aa)
ROCK2Rho-associated protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1360 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1475 aa)
GRIA1Glutamate receptor 1 isoform X2. (907 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X1. (512 aa)
MAPK1Mitogen-activated protein kinase. (363 aa)
PDE3APhosphodiesterase. (989 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A. (1412 aa)
DRD2D(2) dopamine receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (429 aa)
SSTSomatostatin. (116 aa)
MYL9Myosin regulatory light chain 9. (191 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase (CaM kinase) II. (189 aa)
PLCE1Phosphoinositide phospholipase C. (2299 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (942 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (378 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (426 aa)
HCAR1LOW QUALITY PROTEIN: hydroxycarboxylic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (337 aa)
HCAR2LOW QUALITY PROTEIN: hydroxycarboxylic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (362 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
ADRB2Beta-2 adrenergic receptor. (418 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1205 aa)
GLP1RGlucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
ORAI1Calcium release-activated calcium channel protein 1. (238 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (149 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (756 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (941 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (358 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (329 aa)
PDE4BPhosphodiesterase. (676 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (982 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
SSTR2Somatostatin receptor type 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
GHSRGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (368 aa)
SSTR1Somatostatin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (391 aa)
PDE4DPhosphodiesterase. (585 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1224 aa)
PDE4CPhosphodiesterase. (719 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (561 aa)
PTCH1Protein patched homolog 1. (1388 aa)
CAMK2B-2Calcium/calmodulin-dependent protein kinase (CaM kinase) II. (88 aa)
CNGA2Cyclic nucleotide gated channel subunit alpha 2. (664 aa)
GLI3Transcriptional activator GLI3. (524 aa)
PLD1Phospholipase. (1067 aa)
ACOX3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (701 aa)
HTR1E5-hydroxytryptamine receptor 1E. (365 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
RELATranscription factor p65. (585 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (638 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
NFKBIANF-kappa-B inhibitor alpha. (253 aa)
AFDNAfadin. (1770 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (992 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
TSHBThyroid stimulating hormone subunit beta. (140 aa)
CNGA3Cyclic nucleotide-gated cation channel alpha-3 isoform X1. (684 aa)
PDE10APhosphodiesterase. (714 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1104 aa)
ARAP3arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1. (1542 aa)
GPR119Glucose-dependent insulinotropic receptor; Belongs to the G-protein coupled receptor 1 family. (335 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (519 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (813 aa)
CALML4Calmodulin-like protein 4 isoform X1. (121 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (318 aa)
GCGGlucagon. (179 aa)
CALML5Calmodulin-like protein 5. (149 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
VAV3Guanine nucleotide exchange factor VAV3. (782 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (856 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (319 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma. (579 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
RYR2Ryanodine receptor 2. (4923 aa)
GRIN3ALOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1042 aa)
HTR1D5-hydroxytryptamine receptor 1D. (377 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
VIPR2Vasoactive intestinal polypeptide receptor 2; Belongs to the G-protein coupled receptor 2 family. (423 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (691 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (296 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (332 aa)
LOC103659828Ras-related protein Rap-1b-like. (122 aa)
PLD2-2Phospholipase D1/2. (129 aa)
PTGER2Prostaglandin E2 receptor EP2 subtype; Belongs to the G-protein coupled receptor 1 family. (408 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (418 aa)
ENSUMAP00000020007Guanine nucleotide-binding protein G(s) subunit alpha. (68 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
BRAFSerine/threonine-protein kinase B-raf. (715 aa)
CNGB3Cyclic nucleotide gated channel subunit beta 3. (782 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4 isoform X1. (791 aa)
CREB3L1LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 1. (501 aa)
HHIPHedgehog-interacting protein isoform X1. (700 aa)
HTR1B5-hydroxytryptamine receptor 1B. (389 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV. (481 aa)
ADCY10Adenylate cyclase type 10. (1611 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1. (1457 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (237 aa)
RRAS2LOW QUALITY PROTEIN: ras-related protein R-Ras2. (194 aa)
PDE3BPhosphodiesterase. (970 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (169 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (247 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
EDN1Endothelin-1. (202 aa)
LOC103682502Free fatty acid receptor 2-like; Belongs to the G-protein coupled receptor 1 family. (328 aa)
FFAR2Free fatty acid receptor 2-like; Belongs to the G-protein coupled receptor 1 family. (330 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1240 aa)
GHRLAppetite-regulating hormone isoform X1. (134 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1; Belongs to the G-protein coupled receptor 3 family. (815 aa)
PPARAPeroxisome proliferator-activated receptor alpha isoform X1. (468 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (520 aa)
FSHBFollicle stimulating hormone subunit beta. (129 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide isoform X2. (161 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
NPY1RLOW QUALITY PROTEIN: neuropeptide Y receptor type 1; Belongs to the G-protein coupled receptor 1 family. (338 aa)
GLI1Zinc finger protein GLI1. (1097 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (304 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2127 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4. (393 aa)
RAP1BRas-related protein Rap-1b. (184 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1034 aa)
CNGB1LOW QUALITY PROTEIN: cyclic nucleotide-gated cation channel beta-1. (790 aa)
EP300LOW QUALITY PROTEIN: histone acetyltransferase p300. (2390 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1163 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1274 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
NPPANatriuretic peptides A. (182 aa)
RHOARas homolog family member A. (193 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1034 aa)
GRIA3LOW QUALITY PROTEIN: glutamate receptor 3. (860 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
VIPVasoactive intestinal peptide. (170 aa)
DRD1D(1A) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (446 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TNNI3Troponin I, cardiac muscle isoform X2. (205 aa)
AKT1Non-specific serine/threonine protein kinase. (514 aa)
MC2RAdrenocorticotropic hormone receptor. (297 aa)
MAPK10Mitogen-activated protein kinase. (460 aa)
PDE4APhosphodiesterase. (589 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1038 aa)
ABCC4Multidrug resistance-associated protein 4. (1320 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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