(93 nodes) Oocyte meiosis network (Ursus maritimus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PKMYT1	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1; Belongs to the protein kinase superfamily. (497 aa)
	CALML6	Calmodulin-like protein 6. (180 aa)
	CPEB3	Cytoplasmic polyadenylation element-binding protein 3. (313 aa)
	ADCY9	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
	AURKA	Aurora kinase A; Belongs to the protein kinase superfamily. (405 aa)
	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (559 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2714 aa)
	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1. (512 aa)
	MAPK1	Mitogen-activated protein kinase. (363 aa)
	YWHAQ	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (245 aa)
	MAD2L1	Mitotic spindle assembly checkpoint protein MAD2A isoform X2. (195 aa)
	ANAPC4	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (808 aa)
	CAMK2A	Calcium/calmodulin-dependent protein kinase (CaM kinase) II. (189 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily. (378 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (525 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (461 aa)
	ANAPC5	Anaphase-promoting complex subunit 5. (752 aa)
	CALM1	Calmodulin 1; Belongs to the calmodulin family. (149 aa)
	CDK1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
	MAD1L1	LOW QUALITY PROTEIN: mitotic spindle assembly checkpoint protein MAD1. (706 aa)
	PPP2R1B	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (650 aa)
	ANAPC7	Anaphase-promoting complex subunit 7. (565 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (329 aa)
	PPP2CB	Serine/threonine-protein phosphatase. (290 aa)
	PPP2R5B	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
	CCNB1	LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (413 aa)
	LOC103669957	Speedy protein E4-like. (226 aa)
	PGR	Progesterone receptor. (448 aa)
	PLK1	Serine/threonine-protein kinase PLK. (573 aa)
	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (600 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (534 aa)
	CAMK2B-2	Calcium/calmodulin-dependent protein kinase (CaM kinase) II. (88 aa)
	MOS	Proto-oncogene serine/threonine-protein kinase mos; Belongs to the protein kinase superfamily. (349 aa)
	YWHAE	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
	CPEB1	Cytoplasmic polyadenylation element-binding protein 1 isoform X2. (570 aa)
	MAPK14	Mitogen-activated protein kinase. (362 aa)
	ESPL1	Separin. (2106 aa)
	PPP2R1A	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
	STAG3	LOW QUALITY PROTEIN: cohesin subunit SA-3. (1211 aa)
	RPS6KA3	Ribosomal protein S6 kinase. (718 aa)
	MAPK3	Mitogen-activated protein kinase. (354 aa)
	ANAPC1	LOW QUALITY PROTEIN: anaphase-promoting complex subunit 1. (1930 aa)
	CUL1	Cullin-1; Belongs to the cullin family. (776 aa)
	RPS6KA2	Ribosomal protein S6 kinase. (733 aa)
	BUB1	Mitotic checkpoint serine/threonine-protein kinase BUB1. (1071 aa)
	CALML4	Calmodulin-like protein 4 isoform X1. (121 aa)
	CALML5	Calmodulin-like protein 5. (149 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	PPP1CA	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (319 aa)
	CAMK2G	Calcium/calmodulin-dependent protein kinase type II subunit gamma. (579 aa)
	RPS6KA1	Ribosomal protein S6 kinase. (719 aa)
	YWHAG	14-3-3 protein gamma; Belongs to the 14-3-3 family. (238 aa)
	CCNE1	G1/S-specific cyclin-E1; Belongs to the cyclin family. (407 aa)
	PPP2R5E	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
	ANAPC13	Anaphase-promoting complex subunit 13. (74 aa)
	ANAPC10	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (172 aa)
	YWHAH	14-3-3 protein eta; Belongs to the 14-3-3 family. (240 aa)
	CDC27	Cell division cycle protein 27 homolog isoform X1. (825 aa)
	CDK2	Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
	CDC23	Cell division cycle protein 23 homolog isoform X1. (597 aa)
	ANAPC11	Anaphase-promoting complex subunit 11. (84 aa)
	CCNE2	G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa)
	FBXO43	LOW QUALITY PROTEIN: F-box only protein 43. (687 aa)
	YWHAZ	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
	SKP1	S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
	SGO1	Shugoshin-like 1 isoform X1. (530 aa)
	IGF1	Insulin-like growth factor I isoform X1. (184 aa)
	CDC26	Anaphase-promoting complex subunit CDC26. (85 aa)
	SMC1B	Structural maintenance of chromosomes protein. (1235 aa)
	SPDYA	Speedy protein A. (311 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (304 aa)
	CDC16	Cell division cycle protein 16 homolog. (619 aa)
	PPP2R5A	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (522 aa)
	ADCY2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1034 aa)
	PPP3R1	Calcineurin subunit B type 1. (160 aa)
	RBX1	E3 ubiquitin-protein ligase RBX1. (123 aa)
	ADCY8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1163 aa)
	ADCY3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1274 aa)
	MAD2L2	Mitotic spindle assembly checkpoint protein MAD2B. (308 aa)
	ADCY4	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1034 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
	ANAPC2	Anaphase-promoting complex subunit 2; Belongs to the cullin family. (680 aa)
	SLK	STE20-like serine/threonine-protein kinase. (1211 aa)
	SMC3	Structural maintenance of chromosomes protein. (1103 aa)
	CCNB2	G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (397 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1 isoform X3. (2738 aa)
	CDC20	Cell division cycle protein 20 homolog. (499 aa)
	CPEB4	Cytoplasmic polyadenylation element-binding protein 4. (726 aa)
	FBXW11	F-box/WD repeat-containing protein 11 isoform X1. (510 aa)
	PTTG1	Securin. (201 aa)
	ADCY5	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1038 aa)
	YWHAB	14-3-3 protein beta/alpha isoform X3; Belongs to the 14-3-3 family. (244 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY2	ADCY4	ENSUMAP00000029026	ENSUMAP00000031806	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.508
ADCY2	ADCY5	ENSUMAP00000029026	ENSUMAP00000035064	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.994
ADCY2	ADCY8	ENSUMAP00000029026	ENSUMAP00000031215	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.534
ADCY2	ADCY9	ENSUMAP00000029026	ENSUMAP00000002923	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.650
ADCY2	CALM1	ENSUMAP00000029026	ENSUMAP00000008358	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1; Belongs to the calmodulin family.	0.711
ADCY2	CALML4	ENSUMAP00000029026	ENSUMAP00000016295	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-like protein 4 isoform X1.	0.744
ADCY2	CALML5	ENSUMAP00000029026	ENSUMAP00000016509	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-like protein 5.	0.755
ADCY2	CALML6	ENSUMAP00000029026	ENSUMAP00000001723	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-like protein 6.	0.690
ADCY2	CAMK2A	ENSUMAP00000029026	ENSUMAP00000005372	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin-dependent protein kinase (CaM kinase) II.	0.667
ADCY2	CAMK2B-2	ENSUMAP00000029026	ENSUMAP00000013125	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin-dependent protein kinase (CaM kinase) II.	0.667
ADCY2	CAMK2D	ENSUMAP00000029026	ENSUMAP00000004178	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1.	0.705
ADCY2	CAMK2G	ENSUMAP00000029026	ENSUMAP00000017054	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin-dependent protein kinase type II subunit gamma.	0.660
ADCY2	PRKACA	ENSUMAP00000029026	ENSUMAP00000005724	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	cAMP-dependent protein kinase catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.951
ADCY2	PRKACB	ENSUMAP00000029026	ENSUMAP00000003099	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.951
ADCY3	ADCY4	ENSUMAP00000031290	ENSUMAP00000031806	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.524
ADCY3	ADCY5	ENSUMAP00000031290	ENSUMAP00000035064	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.538
ADCY3	ADCY8	ENSUMAP00000031290	ENSUMAP00000031215	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.956
ADCY3	ADCY9	ENSUMAP00000031290	ENSUMAP00000002923	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.961
ADCY3	CALM1	ENSUMAP00000031290	ENSUMAP00000008358	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1; Belongs to the calmodulin family.	0.914
ADCY3	CALML4	ENSUMAP00000031290	ENSUMAP00000016295	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin-like protein 4 isoform X1.	0.917