STRINGSTRING
HYOU1 HYOU1 HERPUD1 HERPUD1 PPP1R15A PPP1R15A STT3B STT3B BAX BAX NSFL1C NSFL1C AMFR AMFR MOGS MOGS STT3A STT3A HSPA5 HSPA5 UBE2J2 UBE2J2 HSP90AA1 HSP90AA1 MAN1A1 MAN1A1 PDIA6 PDIA6 DNAJB1 DNAJB1 DERL3 DERL3 TRAM1L1 TRAM1L1 SEC24D SEC24D RPN2 RPN2 DNAJB11 DNAJB11 MAN1A2 MAN1A2 UBQLN1 UBQLN1 LMAN1 LMAN1 EDEM2 EDEM2 HSP90AB1 HSP90AB1 UBXN4 UBXN4 PLAA PLAA DNAJA1 DNAJA1 BAG1 BAG1 RAD23A RAD23A CALR CALR VCP VCP UBE2D1 UBE2D1 SEL1L SEL1L UFD1 UFD1 CRYAB CRYAB UBXN8 UBXN8 DNAJA2 DNAJA2 SAR1A SAR1A EIF2AK3 EIF2AK3 UGGT1 UGGT1 SYVN1 SYVN1 PDIA3 PDIA3 SEC23A SEC23A ERP29 ERP29 SEC31A SEC31A DNAJB12 DNAJB12 EIF2AK1 EIF2AK1 LOC103662441 LOC103662441 SEC61G SEC61G CAPN1 CAPN1 RNF5 RNF5 UBE2J1 UBE2J1 EIF2S1 EIF2S1 MBTPS2 MBTPS2 PDIA4 PDIA4 SSR3 SSR3 SEC62 SEC62 CUL1 CUL1 PARK2-2 PARK2-2 LOC103665481 LOC103665481 UBE2G1 UBE2G1 MAN1C1 MAN1C1 EIF2AK4 EIF2AK4 SEC61A2 SEC61A2 DERL2 DERL2 ENSUMAP00000018272 ENSUMAP00000018272 HSPA1L HSPA1L HSPA2 HSPA2 DNAJC1 DNAJC1 LOC103679172 LOC103679172 ERO1B ERO1B DAD1 DAD1 DNAJC5B DNAJC5B RAD23B RAD23B GANAB GANAB ATF4 ATF4 UBXN1 UBXN1 ERO1A ERO1A EIF2AK2 EIF2AK2 SEC61A1 SEC61A1 RPN1 RPN1 MAPK8 MAPK8 UBE2D2 UBE2D2 NFE2L2 NFE2L2 MBTPS1 MBTPS1 SIL1 SIL1 XBP1 XBP1 RNF185 RNF185 CAPN2 CAPN2 DNAJC10 DNAJC10 ERN1 ERN1 SEC24A SEC24A SAR1B SAR1B SKP1 SKP1 HSPH1 HSPH1 TXNDC5 TXNDC5 UBQLN4 UBQLN4 SSR2 SSR2 SSR1 SSR1 SEC13 SEC13 BAG2 BAG2 TRAM1 TRAM1 DNAJB2 DNAJB2 DDOST DDOST HSP90B1 HSP90B1 PRKCSH PRKCSH NGLY1 NGLY1 EDEM1 EDEM1 DDIT3 DDIT3 SEC63 SEC63 OS9 OS9 TUSC3 TUSC3 SSR4 SSR4 BCAP31 BCAP31 RBX1 RBX1 PREB PREB DERL1 DERL1 DNAJC5 DNAJC5 EDEM3 EDEM3 HSPA8 HSPA8 HSPA4L HSPA4L SEC31B SEC31B ATF6 ATF6 UBXN2A UBXN2A FBXO6 FBXO6 WFS1 WFS1 MAN1B1 MAN1B1 MAP3K5 MAP3K5 UBE4B UBE4B UBQLN2 UBQLN2 CANX CANX SELENOS SELENOS MAPK9 MAPK9 HSPBP1 HSPBP1 MAPK10 MAPK10 SEC23B SEC23B UGGT2 UGGT2 DNAJC3 DNAJC3 YOD1 YOD1 UBE2G2 UBE2G2 CRYAA CRYAA
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
HYOU1Hypoxia up-regulated protein 1 isoform X2. (996 aa)
HERPUD1Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein. (381 aa)
PPP1R15AProtein phosphatase 1 regulatory subunit 15A. (799 aa)
STT3BDolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B. (751 aa)
BAXApoptosis regulator BAX. (221 aa)
NSFL1CNSFL1 cofactor p47. (347 aa)
AMFRE3 ubiquitin-protein ligase AMFR. (597 aa)
MOGSMannosyl-oligosaccharide glucosidase isoform X1. (763 aa)
STT3ADolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A. (705 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
UBE2J2Ubiquitin-conjugating enzyme E2 J2. (296 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
MAN1A1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (676 aa)
PDIA6Protein disulfide-isomerase A6; Belongs to the protein disulfide isomerase family. (520 aa)
DNAJB1DnaJ heat shock protein family (Hsp40) member B1. (240 aa)
DERL3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (218 aa)
TRAM1L1Translocating chain-associated membrane protein; Belongs to the TRAM family. (370 aa)
SEC24DSEC24 homolog D, COPII coat complex component. (1033 aa)
RPN2Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (683 aa)
DNAJB11dnaJ homolog subfamily B member 11 isoform X2. (386 aa)
MAN1A2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (641 aa)
UBQLN1Ubiquilin-1. (577 aa)
LMAN1Lectin, mannose binding 1. (518 aa)
EDEM2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (568 aa)
HSP90AB1Heat shock protein HSP 90-beta. (699 aa)
UBXN4UBX domain-containing protein 4. (507 aa)
PLAAPhospholipase A-2-activating protein. (739 aa)
DNAJA1dnaJ homolog subfamily A member 1. (383 aa)
BAG1BAG family molecular chaperone regulator 1. (230 aa)
RAD23AUV excision repair protein RAD23 homolog A. (351 aa)
CALRCalreticulin. (417 aa)
VCPTransitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family. (761 aa)
UBE2D1Ubiquitin-conjugating enzyme E2 D1 isoform X2; Belongs to the ubiquitin-conjugating enzyme family. (109 aa)
SEL1LSEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (794 aa)
UFD1Ubiquitin recognition factor in ER associated degradation 1. (302 aa)
CRYABAlpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
UBXN8UBX domain-containing protein 8 isoform X1. (276 aa)
DNAJA2dnaJ homolog subfamily A member 2. (389 aa)
SAR1ASecretion associated Ras related GTPase 1A; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3. (963 aa)
UGGT1UDP-glucose:glycoprotein glucosyltransferase 1. (1553 aa)
SYVN1E3 ubiquitin-protein ligase synoviolin. (573 aa)
PDIA3Protein disulfide-isomerase. (458 aa)
SEC23AProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (765 aa)
ERP29Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. (261 aa)
SEC31AProtein transport protein Sec31A isoform X1. (1292 aa)
DNAJB12DnaJ heat shock protein family (Hsp40) member B12. (373 aa)
EIF2AK1Eukaryotic translation initiation factor 2-alpha kinase 1. (627 aa)
LOC103662441Caspase-12-like isoform X1; Belongs to the peptidase C14A family. (493 aa)
SEC61GProtein transport protein Sec61 subunit gamma. (93 aa)
CAPN1Calpain-1 catalytic subunit; Belongs to the peptidase C2 family. (740 aa)
RNF5E3 ubiquitin-protein ligase RNF5. (180 aa)
UBE2J1Ubiquitin-conjugating enzyme E2 J1. (313 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
MBTPS2Membrane-bound transcription factor site-2 protease. (500 aa)
PDIA4Protein disulfide-isomerase. (567 aa)
SSR3Translocon-associated protein subunit gamma. (185 aa)
SEC62SEC62 homolog, preprotein translocation factor. (399 aa)
CUL1Cullin-1; Belongs to the cullin family. (776 aa)
PARK2-2E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (176 aa)
LOC103665481Putative Bcl-2 homologous antagonist/killer 2. (349 aa)
UBE2G1Ubiquitin-conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
MAN1C1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (603 aa)
EIF2AK4Eukaryotic translation initiation factor 2-alpha kinase 4. (1595 aa)
SEC61A2Protein transport protein SEC61 subunit alpha. (234 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (165 aa)
ENSUMAP00000018272Heat shock 70 kDa protein 1-like. (301 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (636 aa)
DNAJC1dnaJ homolog subfamily C member 1. (553 aa)
LOC103679172LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 D3-like. (139 aa)
ERO1BERO1-like protein beta. (433 aa)
DAD1Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (113 aa)
DNAJC5BDnaJ heat shock protein family (Hsp40) member C5 beta. (199 aa)
RAD23BLOW QUALITY PROTEIN: UV excision repair protein RAD23 homolog B. (369 aa)
GANABNeutral alpha-glucosidase AB isoform X1; Belongs to the glycosyl hydrolase 31 family. (265 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
UBXN1UBX domain-containing protein 1 isoform X1. (290 aa)
ERO1AEndoplasmic reticulum oxidoreductase 1 alpha. (433 aa)
EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinase. (542 aa)
SEC61A1Protein transport protein Sec61 subunit alpha isoform 1. (423 aa)
RPN1Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (558 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
UBE2D2Ubiquitin-conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (118 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform X2. (590 aa)
MBTPS1Membrane bound transcription factor peptidase, site 1. (1052 aa)
SIL1Nucleotide exchange factor SIL1 isoform X1. (499 aa)
XBP1LOW QUALITY PROTEIN: X-box-binding protein 1. (211 aa)
RNF185E3 ubiquitin-protein ligase RNF185. (192 aa)
CAPN2Calpain-2 catalytic subunit; Belongs to the peptidase C2 family. (649 aa)
DNAJC10DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. (794 aa)
ERN1Serine/threonine-protein kinase/endoribonuclease IRE1. (1029 aa)
SEC24ASEC24 homolog A, COPII coat complex component. (1100 aa)
SAR1BSecretion associated Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
SKP1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
HSPH1LOW QUALITY PROTEIN: heat shock protein 105 kDa. (838 aa)
TXNDC5Thioredoxin domain-containing protein 5; Belongs to the protein disulfide isomerase family. (392 aa)
UBQLN4LOW QUALITY PROTEIN: ubiquilin-4. (307 aa)
SSR2Translocon-associated protein subunit beta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. (187 aa)
SSR1Translocon-associated protein subunit alpha isoform X2. (318 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (322 aa)
BAG2BAG family molecular chaperone regulator 2. (220 aa)
TRAM1Translocating chain-associated membrane protein; Belongs to the TRAM family. (373 aa)
DNAJB2dnaJ homolog subfamily B member 2 isoform X1. (304 aa)
DDOSTDolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...] (438 aa)
HSP90B1Endoplasmin. (350 aa)
PRKCSHGlucosidase 2 subunit beta. (472 aa)
NGLY1peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase. (626 aa)
EDEM1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (528 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
SEC63SEC63 homolog, protein translocation regulator. (720 aa)
OS9Protein OS-9. (672 aa)
TUSC3Tumor suppressor candidate 3. (291 aa)
SSR4Translocon-associated protein subunit delta. (169 aa)
BCAP31B-cell receptor-associated protein 31. (246 aa)
RBX1E3 ubiquitin-protein ligase RBX1. (123 aa)
PREBProlactin regulatory element-binding protein. (418 aa)
DERL1Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
DNAJC5dnaJ homolog subfamily C member 5. (164 aa)
EDEM3alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (909 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
HSPA4LLOW QUALITY PROTEIN: heat shock 70 kDa protein 4L. (929 aa)
SEC31BSEC31 homolog B, COPII coat complex component. (1179 aa)
ATF6Cyclic AMP-dependent transcription factor ATF-6 alpha. (676 aa)
UBXN2AUBX domain-containing protein 2A. (249 aa)
FBXO6F-box only protein 6. (356 aa)
WFS1LOW QUALITY PROTEIN: wolframin. (853 aa)
MAN1B1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (355 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1768 aa)
UBE4BUbiquitin conjugation factor E4 B. (1173 aa)
UBQLN2Ubiquilin-2. (599 aa)
CANXCalnexin. (599 aa)
SELENOSSelenoprotein S. (183 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
HSPBP1Hsp70-binding protein 1 isoform X2. (421 aa)
MAPK10Mitogen-activated protein kinase. (460 aa)
SEC23BProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (767 aa)
UGGT2UDP-glucose:glycoprotein glucosyltransferase 2. (1516 aa)
DNAJC3dnaJ homolog subfamily C member 3. (482 aa)
YOD1Ubiquitin thioesterase OTU1. (348 aa)
UBE2G2Ubiquitin-conjugating enzyme E2 G2 isoform X2; Belongs to the ubiquitin-conjugating enzyme family. (164 aa)
CRYAAAlpha-crystallin A chain; Belongs to the small heat shock protein (HSP20) family. (177 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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