23 items (Ursus maritimus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

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Others

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protein homology

Your Input:
	BCL2L1	Bcl-2-like protein 1 isoform X1. (233 aa)
	BAX	Apoptosis regulator BAX. (221 aa)
	CYCS	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	DIABLO	Diablo homolog, mitochondrial. (270 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1252 aa)
	FADD	FAS-associated death domain protein. (192 aa)
	TNFRSF1A	LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A. (507 aa)
	BIRC2	Baculoviral IAP repeat-containing protein 2. (619 aa)
	BOK	Bcl-2-related ovarian killer protein. (300 aa)
	BID	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
	BECN2	Beclin-2. (433 aa)
	LOC103665481	Putative Bcl-2 homologous antagonist/killer 2. (349 aa)
	CASP3	Caspase-3 isoform X1; Belongs to the peptidase C14A family. (302 aa)
	MAPK8	Mitogen-activated protein kinase. (384 aa)
	BIRC6	Baculoviral IAP repeat-containing protein 6. (4808 aa)
	CASP8	Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
	CASP9	Caspase-9 isoform X1; Belongs to the peptidase C14A family. (413 aa)
	SEPTIN4	Septin-4 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (477 aa)
	CASP7	Caspase-7; Belongs to the peptidase C14A family. (301 aa)
	XIAP	E3 ubiquitin-protein ligase XIAP. (497 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	MAPK10	Mitogen-activated protein kinase. (460 aa)
	BECN1	Beclin-1 isoform X1. (555 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BAX	ENSUMAP00000007241	ENSUMAP00000001480	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Apoptosis regulator BAX.	0.638
APAF1	BCL2L1	ENSUMAP00000007241	ENSUMAP00000000792	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Bcl-2-like protein 1 isoform X1.	0.731
APAF1	BID	ENSUMAP00000007241	ENSUMAP00000015536	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.495
APAF1	BIRC2	ENSUMAP00000007241	ENSUMAP00000012471	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat-containing protein 2.	0.661
APAF1	BIRC6	ENSUMAP00000007241	ENSUMAP00000026415	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat-containing protein 6.	0.875
APAF1	BOK	ENSUMAP00000007241	ENSUMAP00000014244	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Bcl-2-related ovarian killer protein.	0.601
APAF1	CASP3	ENSUMAP00000007241	ENSUMAP00000018732	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-3 isoform X1; Belongs to the peptidase C14A family.	0.994
APAF1	CASP7	ENSUMAP00000007241	ENSUMAP00000033891	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-7; Belongs to the peptidase C14A family.	0.878
APAF1	CASP8	ENSUMAP00000007241	ENSUMAP00000029788	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-8 isoform X1; Belongs to the peptidase C14A family.	0.926
APAF1	CASP9	ENSUMAP00000007241	ENSUMAP00000030022	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-9 isoform X1; Belongs to the peptidase C14A family.	0.999
APAF1	CYCS	ENSUMAP00000007241	ENSUMAP00000001665	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	DIABLO	ENSUMAP00000007241	ENSUMAP00000006863	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Diablo homolog, mitochondrial.	0.770
APAF1	FADD	ENSUMAP00000007241	ENSUMAP00000009429	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	FAS-associated death domain protein.	0.664
APAF1	LOC103665481	ENSUMAP00000007241	ENSUMAP00000016562	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Putative Bcl-2 homologous antagonist/killer 2.	0.734
APAF1	XIAP	ENSUMAP00000007241	ENSUMAP00000034003	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	E3 ubiquitin-protein ligase XIAP.	0.850
BAX	APAF1	ENSUMAP00000001480	ENSUMAP00000007241	Apoptosis regulator BAX.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.638
BAX	BCL2L1	ENSUMAP00000001480	ENSUMAP00000000792	Apoptosis regulator BAX.	Bcl-2-like protein 1 isoform X1.	0.942
BAX	BECN1	ENSUMAP00000001480	ENSUMAP00000034805	Apoptosis regulator BAX.	Beclin-1 isoform X1.	0.572
BAX	BECN2	ENSUMAP00000001480	ENSUMAP00000015995	Apoptosis regulator BAX.	Beclin-2.	0.522
BAX	BID	ENSUMAP00000001480	ENSUMAP00000015536	Apoptosis regulator BAX.	BH3-interacting domain death agonist; Counters the protective effect of Bcl-2.	0.998