STRINGSTRING
IL6 IL6 TLR1 TLR1 TLR6 TLR6 IL12B IL12B TIRAP TIRAP IRF3 IRF3 MAPK1 MAPK1 CTSK CTSK LBP LBP SPP1 SPP1 TLR4 TLR4 MAP2K3 MAP2K3 NFKB1 NFKB1 TLR7 TLR7 TLR8 TLR8 MYD88 MYD88 TRAF3 TRAF3 CXCL8 CXCL8 IRF5 IRF5 FADD FADD CXCL9 CXCL9 CXCL10 CXCL10 CXCL11 CXCL11 MAP2K6 MAP2K6 FOS FOS PIK3CA PIK3CA PIK3R1 PIK3R1 IL1B IL1B PIK3R2 PIK3R2 MAPK14 MAPK14 RELA RELA MAPK3 MAPK3 IL12A IL12A NFKBIA NFKBIA AKT3 AKT3 MAP2K1 MAP2K1 TLR3 TLR3 MAP3K7 MAP3K7 CD14 CD14 TAB1 TAB1 PIK3CB PIK3CB TNF TNF MAPK8 MAPK8 MAP3K8 MAP3K8 LOC103662147 LOC103662147 TLR2 TLR2 TLR5 TLR5 CCL5 CCL5 CCL4 CCL4 LOC103667299 LOC103667299 LOC103667298 LOC103667298 CCL3L3 CCL3L3 TRAF6 TRAF6 RIPK1 RIPK1 LY96 LY96 IKBKG IKBKG AKT2 AKT2 IFNAR1 IFNAR1 STAT1 STAT1 TBK1 TBK1 MAP2K4 MAP2K4 CASP8 CASP8 CHUK CHUK PIK3R3 PIK3R3 IRAK4 IRAK4 MAPK9 MAPK9 LOC103680386 LOC103680386 AKT1 AKT1 MAPK10 MAPK10 CD40 CD40 CD86 CD86 CD80 CD80 IKBKB IKBKB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL6Interleukin-6. (189 aa)
TLR1Toll-like receptor 1; Belongs to the Toll-like receptor family. (794 aa)
TLR6Toll-like receptor 6; Belongs to the Toll-like receptor family. (794 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
TIRAPLOW QUALITY PROTEIN: toll/interleukin-1 receptor domain-containing adapter protein. (225 aa)
IRF3Interferon regulatory factor 3 isoform X2. (421 aa)
MAPK1Mitogen-activated protein kinase. (363 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (330 aa)
LBPLipopolysaccharide-binding protein. (481 aa)
SPP1Secreted phosphoprotein 1. (298 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1050 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1039 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (150 aa)
IRF5Interferon regulatory factor 5. (518 aa)
FADDFAS-associated death domain protein. (192 aa)
CXCL9C-X-C motif chemokine 9 isoform X1. (153 aa)
CXCL10C-X-C motif chemokine. (98 aa)
CXCL11C-X-C motif chemokine. (94 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (331 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (561 aa)
MAPK14Mitogen-activated protein kinase. (362 aa)
RELATranscription factor p65. (585 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
NFKBIANF-kappa-B inhibitor alpha. (253 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (519 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
TLR3Toll-like receptor 3 isoform X1; Belongs to the Toll-like receptor family. (905 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CD14Monocyte differentiation antigen CD14 isoform X2. (439 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (498 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
LOC103662147Interferon alpha-1/2-like. (197 aa)
TLR2LOW QUALITY PROTEIN: toll-like receptor 2; Belongs to the Toll-like receptor family. (743 aa)
TLR5Toll-like receptor 5 isoform X1; Belongs to the Toll-like receptor family. (883 aa)
CCL5C-C motif chemokine. (91 aa)
CCL4C-C motif chemokine. (83 aa)
LOC103667299Regakine-1-like. (93 aa)
LOC103667298C-C motif chemokine. (93 aa)
CCL3L3C-C motif chemokine. (93 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
LY96Lymphocyte antigen 96. (160 aa)
IKBKGNF-kappa-B essential modulator. (291 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (520 aa)
IFNAR1Interferon alpha/beta receptor 1. (557 aa)
STAT1Signal transducer and activator of transcription. (809 aa)
TBK1Serine/threonine-protein kinase TBK1. (729 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (411 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (680 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
LOC103680386Interferon alpha-1/2-like. (187 aa)
AKT1Non-specific serine/threonine protein kinase. (514 aa)
MAPK10Mitogen-activated protein kinase. (460 aa)
CD40Tumor necrosis factor receptor superfamily member 5 isoform X5. (316 aa)
CD86T-lymphocyte activation antigen CD86 isoform X1. (343 aa)
CD80T-lymphocyte activation antigen CD80. (302 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.