47 items (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NLRX1	NLR family member X1. (1463 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
	RNF125	E3 ubiquitin-protein ligase RNF125 isoform X4. (232 aa)
	IRF3	Interferon regulatory factor 3 isoform X2. (421 aa)
	ISG15	ISG15 ubiquitin like modifier. (157 aa)
	MAVS	LOW QUALITY PROTEIN: mitochondrial antiviral-signaling protein. (710 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
	IFNE	Interferon epsilon. (204 aa)
	IFNK	Interferon kappa. (208 aa)
	DDX58	Probable ATP-dependent RNA helicase DDX58 isoform X1. (928 aa)
	CYLD	LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family. (948 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (150 aa)
	FADD	FAS-associated death domain protein. (192 aa)
	OTUD5	OTU domain-containing protein 5. (439 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	TANK	TRAF family member-associated NF-kappa-B activator isoform X2. (426 aa)
	MAP3K1	LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1. (1362 aa)
	MAPK14	Mitogen-activated protein kinase. (362 aa)
	DDX3Y	LOW QUALITY PROTEIN: ATP-dependent RNA helicase DDX3X-like; Belongs to the DEAD box helicase family. (704 aa)
	RELA	Transcription factor p65. (585 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
	NFKBIA	NF-kappa-B inhibitor alpha. (253 aa)
	TKFC	Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (Cyclizing). (724 aa)
	IFIH1	Interferon-induced helicase C domain-containing protein 1 isoform X1. (1016 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	MAPK8	Mitogen-activated protein kinase. (384 aa)
	STING1	Stimulator of interferon genes protein. (378 aa)
	LOC103662147	Interferon alpha-1/2-like. (197 aa)
	TBKBP1	TANK-binding kinase 1-binding protein 1. (162 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	RIPK1	Receptor-interacting serine/threonine-protein kinase 1. (665 aa)
	IKBKG	NF-kappa-B essential modulator. (291 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	TRADD	Tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2. (314 aa)
	TBK1	Serine/threonine-protein kinase TBK1. (729 aa)
	CASP10	Caspase-10 isoform X1; Belongs to the peptidase C14A family. (481 aa)
	CASP8	Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
	CHUK	Inhibitor of nuclear factor kappa-B kinase subunit alpha. (680 aa)
	AZI2	5-azacytidine-induced protein 2 isoform X1. (399 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	LOC103680386	Interferon alpha-1/2-like. (187 aa)
	MAPK10	Mitogen-activated protein kinase. (460 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (133 aa)
	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	ATG5	ENSUMAP00000032991	ENSUMAP00000027625	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	DDX58	ENSUMAP00000032991	ENSUMAP00000007520	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Probable ATP-dependent RNA helicase DDX58 isoform X1.	0.953
ATG12	FADD	ENSUMAP00000032991	ENSUMAP00000009429	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	FAS-associated death domain protein.	0.505
ATG12	IFIH1	ENSUMAP00000032991	ENSUMAP00000016375	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Interferon-induced helicase C domain-containing protein 1 isoform X1.	0.531
ATG12	MAVS	ENSUMAP00000032991	ENSUMAP00000005328	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	LOW QUALITY PROTEIN: mitochondrial antiviral-signaling protein.	0.967
ATG12	NLRX1	ENSUMAP00000032991	ENSUMAP00000000047	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	NLR family member X1.	0.448
ATG5	ATG12	ENSUMAP00000027625	ENSUMAP00000032991	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG5	CASP10	ENSUMAP00000027625	ENSUMAP00000029779	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase-10 isoform X1; Belongs to the peptidase C14A family.	0.478
ATG5	CASP8	ENSUMAP00000027625	ENSUMAP00000029788	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase-8 isoform X1; Belongs to the peptidase C14A family.	0.617
ATG5	DDX58	ENSUMAP00000027625	ENSUMAP00000007520	Autophagy protein 5; Involved in autophagic vesicle formation.	Probable ATP-dependent RNA helicase DDX58 isoform X1.	0.953
ATG5	FADD	ENSUMAP00000027625	ENSUMAP00000009429	Autophagy protein 5; Involved in autophagic vesicle formation.	FAS-associated death domain protein.	0.892
ATG5	IFIH1	ENSUMAP00000027625	ENSUMAP00000016375	Autophagy protein 5; Involved in autophagic vesicle formation.	Interferon-induced helicase C domain-containing protein 1 isoform X1.	0.527
ATG5	MAVS	ENSUMAP00000027625	ENSUMAP00000005328	Autophagy protein 5; Involved in autophagic vesicle formation.	LOW QUALITY PROTEIN: mitochondrial antiviral-signaling protein.	0.961
ATG5	NLRX1	ENSUMAP00000027625	ENSUMAP00000000047	Autophagy protein 5; Involved in autophagic vesicle formation.	NLR family member X1.	0.454
ATG5	RIPK1	ENSUMAP00000027625	ENSUMAP00000025734	Autophagy protein 5; Involved in autophagic vesicle formation.	Receptor-interacting serine/threonine-protein kinase 1.	0.419
ATG5	TBK1	ENSUMAP00000027625	ENSUMAP00000028076	Autophagy protein 5; Involved in autophagic vesicle formation.	Serine/threonine-protein kinase TBK1.	0.402
ATG5	TNF	ENSUMAP00000027625	ENSUMAP00000020603	Autophagy protein 5; Involved in autophagic vesicle formation.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.442
AZI2	CHUK	ENSUMAP00000032271	ENSUMAP00000031552	5-azacytidine-induced protein 2 isoform X1.	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	0.546
AZI2	IKBKB	ENSUMAP00000032271	ENSUMAP00000035567	5-azacytidine-induced protein 2 isoform X1.	Inhibitor of nuclear factor kappa-B kinase subunit beta.	0.546
AZI2	IKBKG	ENSUMAP00000032271	ENSUMAP00000026490	5-azacytidine-induced protein 2 isoform X1.	NF-kappa-B essential modulator.	0.919