STRINGSTRING
CD48 CD48 PTK2B PTK2B LOC103679857 LOC103679857 PLCG1 PLCG1 LOC103666917 LOC103666917 KRAS KRAS MAPK1 MAPK1 PTPN6 PTPN6 PPP3CC PPP3CC PPP3CA PPP3CA HRAS HRAS SH3BP2 SH3BP2 CSF2 CSF2 SOS2 SOS2 PIK3CA PIK3CA PIK3R1 PIK3R1 TNFSF10 TNFSF10 LCK LCK GRB2 GRB2 PIK3R2 PIK3R2 PPP3CB PPP3CB PTPN11 PTPN11 MAPK3 MAPK3 PRKCG PRKCG PAK1 PAK1 BID BID NRAS NRAS LOC103664097 LOC103664097 MAP2K1 MAP2K1 FAS FAS VAV3 VAV3 VAV1 VAV1 ITGAL ITGAL SOS1 SOS1 CASP3 CASP3 SHC4 SHC4 PIK3CB PIK3CB BRAF BRAF NCR3 NCR3 TNF TNF PLCG2 PLCG2 LOC103662147 LOC103662147 LOC103669127 LOC103669127 LOC103669128 LOC103669128 LOC103669129 LOC103669129 SHC3 SHC3 KLRK1 KLRK1 KLRD1 KLRD1 SYK SYK CD247 CD247 ICAM2 ICAM2 RAF1 RAF1 SHC1 SHC1 FASLG FASLG IFNAR1 IFNAR1 IFNGR2 IFNGR2 IFNG IFNG PRKCA PRKCA PPP3R1 PPP3R1 SH2D1B SH2D1B LOC103658250 LOC103658250 GZMB GZMB IFNGR1 IFNGR1 PIK3R3 PIK3R3 FCER1G FCER1G CD244 CD244 NFATC2 NFATC2 SH2D1A SH2D1A LCP2 LCP2 LOC103680386 LOC103680386 ICAM1 ICAM1 ITGB2 ITGB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD48CD48 antigen. (245 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
LOC103679857NKG2D ligand 1-like. (244 aa)
PLCG1Phosphoinositide phospholipase C. (1178 aa)
LOC103666917NKG2D ligand 1-like. (249 aa)
KRASGTPase KRas isoform X3. (189 aa)
MAPK1Mitogen-activated protein kinase. (363 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type 6. (592 aa)
PPP3CCSerine/threonine-protein phosphatase. (525 aa)
PPP3CASerine/threonine-protein phosphatase. (461 aa)
HRASGTPase HRas isoform X1. (189 aa)
SH3BP2SH3 domain-binding protein 2. (553 aa)
CSF2Granulocyte-macrophage colony-stimulating factor isoform X1. (277 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1272 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
TNFSF10Tumor necrosis factor ligand superfamily member 10; Belongs to the tumor necrosis factor family. (286 aa)
LCKTyrosine-protein kinase. (355 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (561 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (600 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (654 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
LOC103664097Natural cytotoxicity triggering receptor 2-like. (205 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X1. (351 aa)
VAV3Guanine nucleotide exchange factor VAV3. (782 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
ITGALIntegrin alpha-L isoform X1; Belongs to the integrin alpha chain family. (1167 aa)
SOS1Son of sevenless homolog 1. (1276 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (302 aa)
SHC4SHC-transforming protein 4. (630 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
BRAFSerine/threonine-protein kinase B-raf. (715 aa)
NCR3LOW QUALITY PROTEIN: natural cytotoxicity triggering receptor 3. (182 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1191 aa)
LOC103662147Interferon alpha-1/2-like. (197 aa)
LOC103669127NKG2-F type II integral membrane protein-like isoform X1. (229 aa)
LOC103669128NKG2-A/NKG2-B type II integral membrane protein-like isoform X1. (180 aa)
LOC103669129NKG2-A/NKG2-B type II integral membrane protein-like. (228 aa)
SHC3SHC-transforming protein 3 isoform X2. (425 aa)
KLRK1NKG2-D type II integral membrane protein isoform X1. (180 aa)
KLRD1Natural killer cells antigen CD94 isoform X1. (179 aa)
SYKTyrosine-protein kinase SYK; Belongs to the protein kinase superfamily. Tyr protein kinase family. (610 aa)
CD247T-cell surface glycoprotein CD3 zeta chain isoform X1. (257 aa)
ICAM2Intercellular adhesion molecule 2 isoform X1. (340 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
SHC1LOW QUALITY PROTEIN: SHC-transforming protein 1. (569 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (269 aa)
IFNAR1Interferon alpha/beta receptor 1. (557 aa)
IFNGR2Interferon gamma receptor 2. (377 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
PPP3R1Calcineurin subunit B type 1. (160 aa)
SH2D1BSH2 domain-containing protein 1B. (143 aa)
LOC103658250Low affinity immunoglobulin gamma Fc region receptor III-B-like isoform X1. (249 aa)
GZMBGranzyme B-like isoform X1; Belongs to the peptidase S1 family. (260 aa)
IFNGR1Interferon gamma receptor 1. (509 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (86 aa)
CD244Natural killer cell receptor 2B4. (313 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2. (206 aa)
SH2D1ASH2 domain-containing protein 1A. (83 aa)
LCP2Lymphocyte cytosolic protein 2. (537 aa)
LOC103680386Interferon alpha-1/2-like. (187 aa)
ICAM1Intercellular adhesion molecule 1. (331 aa)
ITGB2Integrin beta. (847 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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