82 items (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL6	Interleukin-6. (189 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	RORC	Nuclear receptor ROR-gamma isoform X1. (518 aa)
	CD3G	T-cell surface glycoprotein CD3 gamma chain. (182 aa)
	CD3D	T-cell surface glycoprotein CD3 delta chain. (171 aa)
	CD3E	T-cell surface glycoprotein CD3 epsilon chain. (201 aa)
	HSP90AA1	Heat shock protein 90 alpha family class A member 1. (733 aa)
	PLCG1	Phosphoinositide phospholipase C. (1178 aa)
	SMAD2	Mothers against decapentaplegic homolog. (449 aa)
	SMAD4	Mothers against decapentaplegic homolog. (546 aa)
	MAPK1	Mitogen-activated protein kinase. (363 aa)
	IL17F	interleukin-17F isoform X1. (159 aa)
	IL17A	interleukin-17A. (161 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
	IL27RA	Interleukin-27 receptor subunit alpha. (636 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (525 aa)
	CD4	T-cell surface glycoprotein CD4. (460 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (461 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
	HSP90AB1	Heat shock protein HSP 90-beta. (699 aa)
	NFKBIE	NF-kappa-B inhibitor epsilon. (357 aa)
	LOC103677394	Transforming growth factor beta-1. (299 aa)
	IL4R	Interleukin-4 receptor subunit alpha. (667 aa)
	IL21R	Interleukin-21 receptor. (449 aa)
	IL23R	Interleukin-23 receptor. (631 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	LCK	Tyrosine-protein kinase. (355 aa)
	JAK1	Tyrosine-protein kinase. (1153 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (331 aa)
	IL6ST	Interleukin-6 receptor subunit beta isoform X1. (918 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (534 aa)
	IL12RB1	LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-1. (724 aa)
	MAPK14	Mitogen-activated protein kinase. (362 aa)
	RELA	Transcription factor p65. (585 aa)
	MAPK3	Mitogen-activated protein kinase. (354 aa)
	NFKBIA	NF-kappa-B inhibitor alpha. (253 aa)
	IL2RA	Interleukin-2 receptor subunit alpha isoform X1. (267 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
	HLA-DOA	HLA class II histocompatibility antigen, DO alpha chain; Belongs to the MHC class II family. (246 aa)
	HLA-DMA	HLA class II histocompatibility antigen, DM alpha chain; Belongs to the MHC class II family. (331 aa)
	LOC103665509	HLA class II histocompatibility antigen, DM beta chain. (280 aa)
	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain isoform X1. (297 aa)
	LOC103665517	DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
	HLA-DQB1	boLa class II histocompatibility antigen, DQB*0101 beta chain-like. (265 aa)
	LOC103665519	SLA class II histocompatibility antigen, DQ haplotype D alpha chain; Belongs to the MHC class II family. (255 aa)
	LOC103665521	DLA class II histocompatibility antigen, DR-1 beta chain. (266 aa)
	HLA-DRA	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (254 aa)
	HIF1A	Hypoxia-inducible factor 1-alpha isoform X2. (823 aa)
	MAPK8	Mitogen-activated protein kinase. (384 aa)
	IL2RB	Interleukin-2 receptor subunit beta. (551 aa)
	TBX21	LOW QUALITY PROTEIN: T-box transcription factor TBX21. (388 aa)
	CD247	T-cell surface glycoprotein CD3 zeta chain isoform X1. (257 aa)
	IL23A	Interleukin-23 subunit alpha. (190 aa)
	JAK2	Tyrosine-protein kinase. (1104 aa)
	STAT6	Signal transducer and activator of transcription. (846 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (132 aa)
	IRF4	Interferon regulatory factor 4 isoform X1. (451 aa)
	NFATC3	Nuclear factor of activated T-cells, cytoplasmic 3. (1067 aa)
	IKBKG	NF-kappa-B essential modulator. (291 aa)
	IFNGR2	Interferon gamma receptor 2. (377 aa)
	RUNX1	Runt-related transcription factor 1. (107 aa)
	STAT1	Signal transducer and activator of transcription. (809 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	IL22	Interleukin-22. (179 aa)
	IL1R1	Interleukin-1 receptor type 1 isoform X1. (572 aa)
	PPP3R1	Calcineurin subunit B type 1. (160 aa)
	AHR	LOW QUALITY PROTEIN: aryl hydrocarbon receptor. (798 aa)
	IL2RG	Cytokine receptor common subunit gamma isoform X2. (374 aa)
	RXRG	Retinoic acid receptor RXR-gamma. (403 aa)
	CHUK	Inhibitor of nuclear factor kappa-B kinase subunit alpha. (680 aa)
	STAT5B	Signal transducer and activator of transcription. (787 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2531 aa)
	IFNGR1	Interferon gamma receptor 1. (509 aa)
	RORA	LOW QUALITY PROTEIN: nuclear receptor ROR-alpha. (522 aa)
	NFATC2	Nuclear factor of activated T-cells, cytoplasmic 2. (206 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	MAPK10	Mitogen-activated protein kinase. (460 aa)
	STAT5A	Signal transducer and activator of transcription. (793 aa)
	STAT3	Signal transducer and activator of transcription. (838 aa)
	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHR	HSP90AA1	ENSUMAP00000030668	ENSUMAP00000002841	LOW QUALITY PROTEIN: aryl hydrocarbon receptor.	Heat shock protein 90 alpha family class A member 1.	0.990
AHR	HSP90AB1	ENSUMAP00000030668	ENSUMAP00000006836	LOW QUALITY PROTEIN: aryl hydrocarbon receptor.	Heat shock protein HSP 90-beta.	0.999
CD247	CD3D	ENSUMAP00000022712	ENSUMAP00000002202	T-cell surface glycoprotein CD3 zeta chain isoform X1.	T-cell surface glycoprotein CD3 delta chain.	0.998
CD247	CD3E	ENSUMAP00000022712	ENSUMAP00000002213	T-cell surface glycoprotein CD3 zeta chain isoform X1.	T-cell surface glycoprotein CD3 epsilon chain.	0.998
CD247	CD3G	ENSUMAP00000022712	ENSUMAP00000002190	T-cell surface glycoprotein CD3 zeta chain isoform X1.	T-cell surface glycoprotein CD3 gamma chain.	0.999
CD247	CD4	ENSUMAP00000022712	ENSUMAP00000006361	T-cell surface glycoprotein CD3 zeta chain isoform X1.	T-cell surface glycoprotein CD4.	0.706
CD247	HLA-DMA	ENSUMAP00000022712	ENSUMAP00000017271	T-cell surface glycoprotein CD3 zeta chain isoform X1.	HLA class II histocompatibility antigen, DM alpha chain; Belongs to the MHC class II family.	0.905
CD247	HLA-DOA	ENSUMAP00000022712	ENSUMAP00000017194	T-cell surface glycoprotein CD3 zeta chain isoform X1.	HLA class II histocompatibility antigen, DO alpha chain; Belongs to the MHC class II family.	0.930
CD247	HLA-DOB	ENSUMAP00000022712	ENSUMAP00000017372	T-cell surface glycoprotein CD3 zeta chain isoform X1.	HLA class II histocompatibility antigen, DO beta chain isoform X1.	0.933
CD247	HLA-DQB1	ENSUMAP00000022712	ENSUMAP00000017401	T-cell surface glycoprotein CD3 zeta chain isoform X1.	boLa class II histocompatibility antigen, DQB*0101 beta chain-like.	0.933
CD247	HLA-DRA	ENSUMAP00000022712	ENSUMAP00000017408	T-cell surface glycoprotein CD3 zeta chain isoform X1.	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family.	0.948
CD247	IL2RB	ENSUMAP00000022712	ENSUMAP00000021460	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Interleukin-2 receptor subunit beta.	0.750
CD247	LCK	ENSUMAP00000022712	ENSUMAP00000011161	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Tyrosine-protein kinase.	0.718
CD247	LOC103665509	ENSUMAP00000022712	ENSUMAP00000017278	T-cell surface glycoprotein CD3 zeta chain isoform X1.	HLA class II histocompatibility antigen, DM beta chain.	0.913
CD247	LOC103665517	ENSUMAP00000022712	ENSUMAP00000017380	T-cell surface glycoprotein CD3 zeta chain isoform X1.	DLA class II histocompatibility antigen, DR-1 beta chain-like.	0.933
CD247	LOC103665519	ENSUMAP00000022712	ENSUMAP00000017404	T-cell surface glycoprotein CD3 zeta chain isoform X1.	SLA class II histocompatibility antigen, DQ haplotype D alpha chain; Belongs to the MHC class II family.	0.955
CD247	LOC103665521	ENSUMAP00000022712	ENSUMAP00000017407	T-cell surface glycoprotein CD3 zeta chain isoform X1.	DLA class II histocompatibility antigen, DR-1 beta chain.	0.933
CD247	PLCG1	ENSUMAP00000022712	ENSUMAP00000002930	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Phosphoinositide phospholipase C.	0.641
CD247	PRKCQ	ENSUMAP00000022712	ENSUMAP00000017009	T-cell surface glycoprotein CD3 zeta chain isoform X1.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.441
CD3D	CD247	ENSUMAP00000002202	ENSUMAP00000022712	T-cell surface glycoprotein CD3 delta chain.	T-cell surface glycoprotein CD3 zeta chain isoform X1.	0.998