STRINGSTRING
CD3G CD3G CD3D CD3D CD3E CD3E TEC TEC BCL10 BCL10 PLCG1 PLCG1 ITK ITK DLG1 DLG1 PAK2 PAK2 KRAS KRAS MAPK1 MAPK1 PTPN6 PTPN6 IL2 IL2 PPP3CC PPP3CC CD4 CD4 MALT1 MALT1 PPP3CA PPP3CA NFKB1 NFKB1 NFKBIE NFKBIE HRAS HRAS CBLB CBLB CSF2 CSF2 SOS2 SOS2 PAK5 PAK5 FOS FOS PIK3CA PIK3CA CD8A CD8A CD8B CD8B PIK3R1 PIK3R1 LCK LCK GRB2 GRB2 PIK3R2 PIK3R2 PPP3CB PPP3CB MAPK14 MAPK14 CD40LG CD40LG PDCD1 PDCD1 RELA RELA MAPK3 MAPK3 NFKBIA NFKBIA PAK1 PAK1 NRAS NRAS AKT3 AKT3 MAP2K1 MAP2K1 MAP3K7 MAP3K7 VAV3 VAV3 PRKCQ PRKCQ VAV1 VAV1 SOS1 SOS1 CDC42 CDC42 GRAP2 GRAP2 RASGRP1 RASGRP1 PIK3CB PIK3CB TNF TNF MAP3K14 MAP3K14 MAPK8 MAPK8 MAP3K8 MAP3K8 CD247 CD247 RAF1 RAF1 IL4 IL4 NFATC3 NFATC3 IKBKG IKBKG AKT2 AKT2 CDK4 CDK4 IFNG IFNG NCK2 NCK2 PPP3R1 PPP3R1 CD28 CD28 CTLA4 CTLA4 ICOS ICOS CHUK CHUK RHOA RHOA PDPK1 PDPK1 PIK3R3 PIK3R3 NFATC2 NFATC2 MAPK9 MAPK9 LCP2 LCP2 AKT1 AKT1 MAPK10 MAPK10 GSK3B GSK3B IL10 IL10 PTPRC PTPRC IKBKB IKBKB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD3GT-cell surface glycoprotein CD3 gamma chain. (182 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (171 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (201 aa)
TECTyrosine-protein kinase. (631 aa)
BCL10BCL10 immune signaling adaptor. (234 aa)
PLCG1Phosphoinositide phospholipase C. (1178 aa)
ITKTyrosine-protein kinase. (620 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
KRASGTPase KRas isoform X3. (189 aa)
MAPK1Mitogen-activated protein kinase. (363 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type 6. (592 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
PPP3CCSerine/threonine-protein phosphatase. (525 aa)
CD4T-cell surface glycoprotein CD4. (460 aa)
MALT1Mucosa-associated lymphoid tissue lymphoma translocation protein 1. (771 aa)
PPP3CASerine/threonine-protein phosphatase. (461 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
NFKBIENF-kappa-B inhibitor epsilon. (357 aa)
HRASGTPase HRas isoform X1. (189 aa)
CBLBE3 ubiquitin-protein ligase CBL-B isoform X1. (983 aa)
CSF2Granulocyte-macrophage colony-stimulating factor isoform X1. (277 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1272 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
CD8AT-cell surface glycoprotein CD8 alpha chain. (239 aa)
CD8BT-cell surface glycoprotein CD8 beta chain. (211 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
LCKTyrosine-protein kinase. (355 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (561 aa)
PPP3CBSerine/threonine-protein phosphatase. (534 aa)
MAPK14Mitogen-activated protein kinase. (362 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
PDCD1Programmed cell death protein 1 isoform X1. (288 aa)
RELATranscription factor p65. (585 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
NFKBIANF-kappa-B inhibitor alpha. (253 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (519 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
VAV3Guanine nucleotide exchange factor VAV3. (782 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
SOS1Son of sevenless homolog 1. (1276 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
GRAP2GRB2 related adaptor protein 2. (316 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (807 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (873 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
CD247T-cell surface glycoprotein CD3 zeta chain isoform X1. (257 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (132 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3. (1067 aa)
IKBKGNF-kappa-B essential modulator. (291 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (520 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
NCK2Cytoplasmic protein. (380 aa)
PPP3R1Calcineurin subunit B type 1. (160 aa)
CD28T-cell-specific surface glycoprotein CD28. (277 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
ICOSInducible T-cell costimulator isoform X1. (209 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (680 aa)
RHOARas homolog family member A. (193 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (572 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2. (206 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
LCP2Lymphocyte cytosolic protein 2. (537 aa)
AKT1Non-specific serine/threonine protein kinase. (514 aa)
MAPK10Mitogen-activated protein kinase. (460 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
IL10Interleukin-10. (178 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C isoform X1. (1268 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.