STRINGSTRING
GNA13 GNA13 FN1 FN1 EGF EGF FGF21 FGF21 LOC103682607 LOC103682607 RRAS RRAS PIP5K1A PIP5K1A CYFIP2 CYFIP2 BDKRB2 BDKRB2 ROCK2 ROCK2 PAK2 PAK2 KRAS KRAS MAPK1 MAPK1 GSN GSN PDGFRA PDGFRA CRKL CRKL SRC SRC MYL9 MYL9 KNG1 KNG1 FGFR2 FGFR2 LOC103657720 LOC103657720 PPP1R12A PPP1R12A FGF2 FGF2 PDGFRB PDGFRB F2R F2R PDGFA PDGFA HRAS HRAS WASL WASL MYH11 MYH11 MYL5 MYL5 ITGA2 ITGA2 ITGA1 ITGA1 SSH1 SSH1 FGF10 FGF10 CXCR4 CXCR4 LPAR2 LPAR2 ITGA9 ITGA9 FGF17 FGF17 ARPC3 ARPC3 PPP1CC PPP1CC RDX RDX FGF19 FGF19 SOS2 SOS2 GNA12 GNA12 MYLK3 MYLK3 PAK5 PAK5 PIK3CA PIK3CA PIK3R1 PIK3R1 FGF5 FGF5 ITGB6 ITGB6 PDGFD PDGFD DOCK1 DOCK1 EGFR EGFR FGFR1 FGFR1 ARPC1A ARPC1A ARPC1B ARPC1B PIK3R2 PIK3R2 IQGAP1 IQGAP1 MYL7 MYL7 MOS MOS CRK CRK SSH2 SSH2 GIT1 GIT1 CFL1 CFL1 MAPK3 MAPK3 NCKAP1L NCKAP1L MYLPF MYLPF PAK1 PAK1 WASF2 WASF2 CFL2 CFL2 FGF1 FGF1 NRAS NRAS SLC9A1 SLC9A1 ITGA11 ITGA11 EZR EZR MAP2K1 MAP2K1 PFN2 PFN2 VAV3 VAV3 PPP1CA PPP1CA CHRM3 CHRM3 VCL VCL DIAPH1 DIAPH1 VAV1 VAV1 ITGAL ITGAL SOS1 SOS1 CDC42 CDC42 PIP4K2A PIP4K2A ARHGEF4 ARHGEF4 ITGA2B ITGA2B PFN1 PFN1 ITGAM ITGAM ITGAX ITGAX F2 F2 CHRM1 CHRM1 FGF7 FGF7 FGF23 FGF23 PIK3CB PIK3CB BRAF BRAF FGF9 FGF9 ITGA6 ITGA6 ACTG1 ACTG1 ENAH ENAH LIMK2 LIMK2 ITGB3 ITGB3 ITGB1 ITGB1 ITGA7 ITGA7 CXCL12 CXCL12 PDGFC PDGFC SPATA13 SPATA13 MYH9 MYH9 ITGA4 ITGA4 CHRM5 CHRM5 TIAM1 TIAM1 APC APC RRAS2 RRAS2 MSN MSN NCKAP1 NCKAP1 PIP4K2B PIP4K2B RAF1 RAF1 MYH10 MYH10 LPAR1 LPAR1 IQGAP3 IQGAP3 BRK1 BRK1 ITGAV ITGAV MYLK4 MYLK4 ARPC4 ARPC4 MYL12B MYL12B MYL12A MYL12A ACTN4 ACTN4 ARPC2 ARPC2 ROCK1 ROCK1 LPAR4 LPAR4 PIP4K2C PIP4K2C PPP1CB PPP1CB PTK2 PTK2 PIP5K1B PIP5K1B FGF20 FGF20 ARHGEF7 ARHGEF7 ABI2 ABI2 ITGB8 ITGB8 RHOA RHOA PFN4 PFN4 PIKFYVE PIKFYVE ARHGEF12 ARHGEF12 ARHGAP35 ARHGAP35 PIK3R3 PIK3R3 FGFR4 FGFR4 FGF18 FGF18 ITGB2 ITGB2 WASF1 WASF1 CYFIP1 CYFIP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNA13Guanine nucleotide-binding protein subunit alpha-13. (300 aa)
FN1Fibronectin isoform X1. (2476 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1159 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
LOC103682607Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (56 aa)
RRASRas-related protein R-Ras. (195 aa)
PIP5K1ALOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha. (530 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1056 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (392 aa)
ROCK2Rho-associated protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1360 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
KRASGTPase KRas isoform X3. (189 aa)
MAPK1Mitogen-activated protein kinase. (363 aa)
GSNGelsolin isoform X1. (748 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
SRCTyrosine-protein kinase. (618 aa)
MYL9Myosin regulatory light chain 9. (191 aa)
KNG1Kininogen-1 isoform X1. (624 aa)
FGFR2Fibroblast growth factor receptor. (602 aa)
LOC103657720Protein phosphatase 1 regulatory subunit. (179 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (942 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1152 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (426 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (288 aa)
HRASGTPase HRas isoform X1. (189 aa)
WASLNeural Wiskott-Aldrich syndrome protein. (489 aa)
MYH11Myosin heavy chain 9/10/11/14. (272 aa)
MYL5Myosin light chain 5. (172 aa)
ITGA2Integrin alpha-2; Belongs to the integrin alpha chain family. (1154 aa)
ITGA1Integrin alpha-1; Belongs to the integrin alpha chain family. (1143 aa)
SSH1Protein phosphatase Slingshot homolog 1 isoform X1. (1173 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
LPAR2Lysophosphatidic acid receptor 2. (203 aa)
ITGA9Integrin alpha-9; Belongs to the integrin alpha chain family. (934 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (329 aa)
RDXRadixin. (604 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1272 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12. (294 aa)
MYLK3Myosin light chain kinase 3. (815 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
PDGFDPlatelet-derived growth factor D. (365 aa)
DOCK1LOW QUALITY PROTEIN: dedicator of cytokinesis protein 1; Belongs to the DOCK family. (1863 aa)
EGFRReceptor protein-tyrosine kinase. (1191 aa)
FGFR1Fibroblast growth factor receptor. (788 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (369 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (561 aa)
IQGAP1Ras GTPase-activating-like protein IQGAP1. (1677 aa)
MYL7Myosin regulatory light chain 2, atrial isoform. (175 aa)
MOSProto-oncogene serine/threonine-protein kinase mos; Belongs to the protein kinase superfamily. (349 aa)
CRKAdapter molecule crk. (287 aa)
SSH2LOW QUALITY PROTEIN: protein phosphatase Slingshot homolog 2. (1427 aa)
GIT1ARF GTPase-activating protein GIT1. (699 aa)
CFL1Cofilin-1; Belongs to the actin-binding proteins ADF family. (166 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
NCKAP1LNck-associated protein 1-like. (1134 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (170 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
WASF2wiskott-Aldrich syndrome protein family member 2. (447 aa)
CFL2Cofilin-2; Belongs to the actin-binding proteins ADF family. (149 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (813 aa)
ITGA11Integrin alpha-11; Belongs to the integrin alpha chain family. (1237 aa)
EZREzrin isoform X1. (629 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PFN2Profilin; Belongs to the profilin family. (98 aa)
VAV3Guanine nucleotide exchange factor VAV3. (782 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (319 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (552 aa)
VCLVinculin isoform X1. (1059 aa)
DIAPH1LOW QUALITY PROTEIN: protein diaphanous homolog 1. (1234 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
ITGALIntegrin alpha-L isoform X1; Belongs to the integrin alpha chain family. (1167 aa)
SOS1Son of sevenless homolog 1. (1276 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha. (398 aa)
ARHGEF4Rho guanine nucleotide exchange factor 4. (691 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1086 aa)
PFN1Profilin; Belongs to the profilin family. (104 aa)
ITGAMIntegrin alpha-M isoform X1; Belongs to the integrin alpha chain family. (1157 aa)
ITGAXIntegrin alpha-X; Belongs to the integrin alpha chain family. (1166 aa)
F2Prothrombin; Belongs to the peptidase S1 family. (569 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (418 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (240 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
BRAFSerine/threonine-protein kinase B-raf. (715 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ITGA6LOW QUALITY PROTEIN: integrin alpha-6; Belongs to the integrin alpha chain family. (1051 aa)
ACTG1LOW QUALITY PROTEIN: actin, cytoplasmic 2. (375 aa)
ENAHProtein enabled homolog. (210 aa)
LIMK2LIM domain kinase 2 isoform X2. (706 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (783 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
ITGA7Integrin alpha-7; Belongs to the integrin alpha chain family. (1162 aa)
CXCL12Stromal cell-derived factor 1; Belongs to the intercrine alpha (chemokine CxC) family. (148 aa)
PDGFCPlatelet-derived growth factor C isoform X1; Belongs to the PDGF/VEGF growth factor family. (186 aa)
SPATA13LOW QUALITY PROTEIN: spermatogenesis-associated protein 13. (749 aa)
MYH9LOW QUALITY PROTEIN: myosin-9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2048 aa)
ITGA4Integrin alpha-4 isoform X2; Belongs to the integrin alpha chain family. (944 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (534 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1. (1457 aa)
APCLOW QUALITY PROTEIN: adenomatous polyposis coli protein. (2824 aa)
RRAS2LOW QUALITY PROTEIN: ras-related protein R-Ras2. (194 aa)
MSNLOW QUALITY PROTEIN: moesin. (577 aa)
NCKAP1Nck-associated protein 1. (1028 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X2. (404 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase. (648 aa)
MYH10LOW QUALITY PROTEIN: myosin-10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1606 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
IQGAP3Ras GTPase-activating-like protein IQGAP3. (1601 aa)
BRK1Protein BRICK1. (156 aa)
ITGAVLOW QUALITY PROTEIN: integrin alpha-V; Belongs to the integrin alpha chain family. (1056 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (387 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (94 aa)
MYL12BMyosin regulatory light chain 12B. (172 aa)
MYL12AMyosin regulatory light polypeptide 9. (172 aa)
ACTN4Alpha-actinin-4. (853 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (327 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma. (457 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (304 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1092 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1. (626 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7 isoform X2. (742 aa)
ABI2Abl interactor 2 isoform X1. (476 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (720 aa)
RHOARas homolog family member A. (193 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
PIKFYVELOW QUALITY PROTEIN: 1-phosphatidylinositol 3-phosphate 5-kinase. (2090 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1526 aa)
ARHGAP35Rho GTPase-activating protein 35. (1500 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
FGFR4Fibroblast growth factor receptor. (795 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
ITGB2Integrin beta. (847 aa)
WASF1wiskott-Aldrich syndrome protein family member 1 isoform X2. (559 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1185 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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