STRINGSTRING
NPY NPY PCK1 PCK1 PPARGC1A PPARGC1A NFKB1 NFKB1 NFKBIE NFKBIE ADIPOR1 ADIPOR1 STK11 STK11 LEP LEP PRKAG1 PRKAG1 ACSL6 ACSL6 TNFRSF1A TNFRSF1A PRKAA1 PRKAA1 LEPR LEPR PRKAB1 PRKAB1 PRKAB2 PRKAB2 PTPN11 PTPN11 RELA RELA ACSBG2 ACSBG2 LOC103681862 LOC103681862 ACSBG1 ACSBG1 NFKBIA NFKBIA AKT3 AKT3 ADIPOR2 ADIPOR2 PRKCQ PRKCQ G6PC3 G6PC3 G6PC2 G6PC2 CD36 CD36 TNF TNF MAPK8 MAPK8 CPT1B CPT1B JAK2 JAK2 CPT1A CPT1A ACSL3 ACSL3 PRKAG3 PRKAG3 IKBKG IKBKG PPARA PPARA AKT2 AKT2 AGRP AGRP TRADD TRADD PRKAA2 PRKAA2 TNFRSF1B TNFRSF1B PCK2 PCK2 RXRG RXRG CHUK CHUK ACSL4 ACSL4 MTOR MTOR ACSL5 ACSL5 SLC2A1 SLC2A1 MAPK9 MAPK9 AKT1 AKT1 MAPK10 MAPK10 STAT3 STAT3 IKBKB IKBKB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NPYPro-neuropeptide Y. (97 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha. (784 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
NFKBIENF-kappa-B inhibitor epsilon. (357 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (457 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (166 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X2. (279 aa)
ACSL6LOW QUALITY PROTEIN: long-chain-fatty-acid--CoA ligase 6. (711 aa)
TNFRSF1ALOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A. (507 aa)
PRKAA1Non-specific serine/threonine protein kinase. (500 aa)
LEPRLeptin receptor isoform X1. (1166 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
PRKAB25'-AMP-activated protein kinase subunit beta-2. (251 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (600 aa)
RELATranscription factor p65. (585 aa)
ACSBG2long-chain-fatty-acid--CoA ligase ACSBG2. (653 aa)
LOC103681862long-chain-fatty-acid--CoA ligase ACSBG2-like. (493 aa)
ACSBG1long-chain-fatty-acid--CoA ligase ACSBG1. (597 aa)
NFKBIANF-kappa-B inhibitor alpha. (253 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (519 aa)
ADIPOR2Adiponectin receptor protein 2. (386 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
G6PC3Glucose-6-phosphatase 3. (365 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
CD36Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family. (472 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
CPT1BCarnitine O-palmitoyltransferase 1, muscle isoform; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
JAK2Tyrosine-protein kinase. (1104 aa)
CPT1ACarnitine O-palmitoyltransferase 1, liver isoform. (775 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3. (491 aa)
IKBKGNF-kappa-B essential modulator. (291 aa)
PPARAPeroxisome proliferator-activated receptor alpha isoform X1. (468 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (520 aa)
AGRPAgouti related neuropeptide. (131 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2. (314 aa)
PRKAA2Non-specific serine/threonine protein kinase. (390 aa)
TNFRSF1BLOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1B. (313 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial. (665 aa)
RXRGRetinoic acid receptor RXR-gamma. (403 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (680 aa)
ACSL4long-chain-fatty-acid--CoA ligase 4 isoform X1. (710 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2531 aa)
ACSL5Acyl-CoA synthetase long chain family member 5. (683 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (500 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
AKT1Non-specific serine/threonine protein kinase. (514 aa)
MAPK10Mitogen-activated protein kinase. (460 aa)
STAT3Signal transducer and activator of transcription. (838 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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