49 items (Ursus maritimus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL6	Interleukin-6. (189 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
	ARF1	ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (219 aa)
	CYCS	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	TLR4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1252 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	VCP	Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family. (761 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (150 aa)
	LOC103665389	C-X-C motif chemokine. (101 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (217 aa)
	SAR1A	Secretion associated Ras related GTPase 1A; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (331 aa)
	BNIP3	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3. (236 aa)
	RELA	Transcription factor p65. (585 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
	NFKBIA	NF-kappa-B inhibitor alpha. (253 aa)
	BCL2L13	Bcl-2-like protein 13 isoform X1. (470 aa)
	EEF1A1	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (445 aa)
	C3	LOW QUALITY PROTEIN: complement C3. (1590 aa)
	EEF1G	Eukaryotic translation elongation factor 1 gamma. (437 aa)
	LOC103666560	Elongation factor 1-alpha, somatic form-like. (461 aa)
	CD14	Monocyte differentiation antigen CD14 isoform X2. (439 aa)
	ENSUMAP00000018272	Heat shock 70 kDa protein 1-like. (301 aa)
	HSPA1L	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
	HSPA2	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (636 aa)
	CASP3	Caspase-3 isoform X1; Belongs to the peptidase C14A family. (302 aa)
	PYCARD	Apoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
	ITGAM	Integrin alpha-M isoform X1; Belongs to the integrin alpha chain family. (1157 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	TLR2	LOW QUALITY PROTEIN: toll-like receptor 2; Belongs to the Toll-like receptor family. (743 aa)
	TLR5	Toll-like receptor 5 isoform X1; Belongs to the Toll-like receptor family. (883 aa)
	SAR1B	Secretion associated Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
	HSF1	Heat shock factor protein 1. (188 aa)
	HSPD1	60 kDa heat shock protein, mitochondrial; Belongs to the chaperonin (HSP60) family. (573 aa)
	RAB1A	Ras-related protein Rab-1A. (211 aa)
	CLK1	Dual specificity protein kinase CLK1 isoform X1; Belongs to the protein kinase superfamily. (484 aa)
	CASP8	Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
	CASP9	Caspase-9 isoform X1; Belongs to the peptidase C14A family. (413 aa)
	EEF1A2	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (440 aa)
	LOC103672539	Complement component receptor 1-like protein. (547 aa)
	HSPA8	Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
	CLK4	Dual specificity protein kinase CLK4 isoform X2; Belongs to the protein kinase superfamily. (481 aa)
	HBS1L	HBS1 like translational GTPase. (685 aa)
	CASP7	Caspase-7; Belongs to the peptidase C14A family. (301 aa)
	ITGB2	Integrin beta. (847 aa)
	LOC103677048	LOW QUALITY PROTEIN: elongation factor 1-alpha 1-like. (440 aa)
	SEC22B	SEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (215 aa)

Your Current Organism:

Ursus maritimus

NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BNIP3	ENSUMAP00000007241	ENSUMAP00000013092	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3.	0.473
APAF1	CASP3	ENSUMAP00000007241	ENSUMAP00000018732	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-3 isoform X1; Belongs to the peptidase C14A family.	0.994
APAF1	CASP7	ENSUMAP00000007241	ENSUMAP00000033891	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-7; Belongs to the peptidase C14A family.	0.878
APAF1	CASP8	ENSUMAP00000007241	ENSUMAP00000029788	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-8 isoform X1; Belongs to the peptidase C14A family.	0.926
APAF1	CASP9	ENSUMAP00000007241	ENSUMAP00000030022	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-9 isoform X1; Belongs to the peptidase C14A family.	0.999
APAF1	CYCS	ENSUMAP00000007241	ENSUMAP00000001665	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	EEF1G	ENSUMAP00000007241	ENSUMAP00000017289	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Eukaryotic translation elongation factor 1 gamma.	0.437
APAF1	ENSUMAP00000018272	ENSUMAP00000007241	ENSUMAP00000018272	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Heat shock 70 kDa protein 1-like.	0.505
APAF1	HBS1L	ENSUMAP00000007241	ENSUMAP00000033858	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	HBS1 like translational GTPase.	0.558
APAF1	HSPA1L	ENSUMAP00000007241	ENSUMAP00000018275	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family.	0.505
APAF1	TNF	ENSUMAP00000007241	ENSUMAP00000020603	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.446
ARF1	RAB1A	ENSUMAP00000000878	ENSUMAP00000028980	ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family.	Ras-related protein Rab-1A.	0.517
ARF1	SEC22B	ENSUMAP00000000878	ENSUMAP00000035649	ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family.	SEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family.	0.536
BCL2L13	BNIP3	ENSUMAP00000015547	ENSUMAP00000013092	Bcl-2-like protein 13 isoform X1.	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3.	0.525
BNIP3	APAF1	ENSUMAP00000013092	ENSUMAP00000007241	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.473
BNIP3	BCL2L13	ENSUMAP00000013092	ENSUMAP00000015547	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3.	Bcl-2-like protein 13 isoform X1.	0.525
BNIP3	CASP3	ENSUMAP00000013092	ENSUMAP00000018732	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3.	Caspase-3 isoform X1; Belongs to the peptidase C14A family.	0.524
BNIP3	CYCS	ENSUMAP00000013092	ENSUMAP00000001665	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.441
C3	CASP3	ENSUMAP00000016842	ENSUMAP00000018732	LOW QUALITY PROTEIN: complement C3.	Caspase-3 isoform X1; Belongs to the peptidase C14A family.	0.440
C3	HSPA8	ENSUMAP00000016842	ENSUMAP00000031158	LOW QUALITY PROTEIN: complement C3.	Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family.	0.424