STRINGSTRING
IL6 IL6 TGFBR2 TGFBR2 TLR6 TLR6 IL12B IL12B CD3G CD3G CD3D CD3D CD3E CD3E LOC103670936 LOC103670936 SMAD2 SMAD2 BDKRB2 BDKRB2 MAPK1 MAPK1 PPP2R2A PPP2R2A TLR4 TLR4 KNG1 KNG1 IL2 IL2 NFKB1 NFKB1 MYD88 MYD88 LOC103677394 LOC103677394 CALR CALR CXCL8 CXCL8 PPP2R1B PPP2R1B FADD FADD PPP2CB PPP2CB GNA15 GNA15 TNFRSF1A TNFRSF1A PLCB4 PLCB4 TGFB3 TGFB3 GNAL GNAL FOS FOS PIK3CA PIK3CA PIK3R1 PIK3R1 IL1B IL1B PIK3R2 PIK3R2 PPP2R2D PPP2R2D PPP2R2B PPP2R2B MAPK14 MAPK14 PPP2R1A PPP2R1A RELA RELA MAPK3 MAPK3 IL12A IL12A NFKBIA NFKBIA SERPINE1 SERPINE1 AKT3 AKT3 C3 C3 FAS FAS TGFBR1 TGFBR1 NOS2 NOS2 GNAI3 GNAI3 C1QB C1QB C1QC C1QC C1QA C1QA GNAI1 GNAI1 ENSUMAP00000020007 ENSUMAP00000020007 PIK3CB PIK3CB TNF TNF CCL2 CCL2 MAPK8 MAPK8 TLR2 TLR2 CD247 CD247 CCL5 CCL5 LOC103667299 LOC103667299 LOC103667298 LOC103667298 CCL3L3 CCL3L3 TRAF6 TRAF6 IKBKG IKBKG AKT2 AKT2 FASLG FASLG IFNGR2 IFNGR2 TGFB2 TGFB2 IFNG IFNG MAP2K4 MAP2K4 CASP8 CASP8 CHUK CHUK PPP2R2C PPP2R2C GNA14 GNA14 GNAQ GNAQ IFNGR1 IFNGR1 PIK3R3 PIK3R3 IRAK4 IRAK4 MAPK9 MAPK9 AKT1 AKT1 MAPK10 MAPK10 IL10 IL10 IKBKB IKBKB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL6Interleukin-6. (189 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TLR6Toll-like receptor 6; Belongs to the Toll-like receptor family. (794 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (182 aa)
CD3DT-cell surface glycoprotein CD3 delta chain. (171 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (201 aa)
LOC103670936Neuroendocrine secretory protein 55. (247 aa)
SMAD2Mothers against decapentaplegic homolog. (449 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (392 aa)
MAPK1Mitogen-activated protein kinase. (363 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
KNG1Kininogen-1 isoform X1. (624 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (155 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (972 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
LOC103677394Transforming growth factor beta-1. (299 aa)
CALRCalreticulin. (417 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (150 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform. (650 aa)
FADDFAS-associated death domain protein. (192 aa)
PPP2CBSerine/threonine-protein phosphatase. (290 aa)
GNA15Guanine nucleotide-binding protein subunit alpha-15. (351 aa)
TNFRSF1ALOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A. (507 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1205 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
GNALGuanine nucleotide-binding protein G(Olf) subunit alpha. (380 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (331 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (561 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (449 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
MAPK14Mitogen-activated protein kinase. (362 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
RELATranscription factor p65. (585 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
NFKBIANF-kappa-B inhibitor alpha. (253 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (519 aa)
C3LOW QUALITY PROTEIN: complement C3. (1590 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X1. (351 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1096 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
C1QBComplement C1q subcomponent subunit B. (249 aa)
C1QCComplement C1q subcomponent subunit C. (270 aa)
C1QAComplement C1q subcomponent subunit A-like. (245 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (332 aa)
ENSUMAP00000020007Guanine nucleotide-binding protein G(s) subunit alpha. (68 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1067 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CCL2C-C motif chemokine. (101 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
TLR2LOW QUALITY PROTEIN: toll-like receptor 2; Belongs to the Toll-like receptor family. (743 aa)
CD247T-cell surface glycoprotein CD3 zeta chain isoform X1. (257 aa)
CCL5C-C motif chemokine. (91 aa)
LOC103667299Regakine-1-like. (93 aa)
LOC103667298C-C motif chemokine. (93 aa)
CCL3L3C-C motif chemokine. (93 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
IKBKGNF-kappa-B essential modulator. (291 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (520 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (269 aa)
IFNGR2Interferon gamma receptor 2. (377 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (411 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (680 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (464 aa)
GNA14Guanine nucleotide-binding protein subunit alpha-14. (348 aa)
GNAQGuanine nucleotide-binding protein G(Q) subunit alpha. (324 aa)
IFNGR1Interferon gamma receptor 1. (509 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
AKT1Non-specific serine/threonine protein kinase. (514 aa)
MAPK10Mitogen-activated protein kinase. (460 aa)
IL10Interleukin-10. (178 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (756 aa)
Your Current Organism:
Ursus maritimus
NCBI taxonomy Id: 29073
Other names: Thalarctos maritimus, U. maritimus, polar bear, white bear
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